Implanted Port Catheter System Infection Caused by Methicillin-resistant &lt;i&gt;Staphylococcus pseudintermedius&lt;/i&gt; ST71-SCC&lt;i&gt;mec&lt;/i&gt; type III

Kitagawa, Hirohisa; Hisatsune, Junzo; Ohge, Hiroki; Kustuno, Shoko; Hara, Takatoshi; Masuda, Kenji; Aziz, Fatkanuddin; Sugai, Motoyuki

doi:10.2169/internalmedicine.5579-20

Cited by 7 publications

(10 citation statements)

References 33 publications

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“…It could be that veterinary personnel acted as carriers and facilitated the transmission of the MRSP‐ST71 clone between animals they handle, or pet owners who interact with other dogs in the community such as in dogs' parks. The MRSP‐ST71 has already been incriminated in potential zoonotic diseases (Kitagawa et al, 2021 ), reflecting the recent emergence of these important multidrug‐resistant bacteria in animal and public health. Conversely, the other clone of high relevance, especially in the USA, MRSP‐ST68, was not reported from nasal cavities of healthy dogs and cats in the studies included in this systematic review.…”

Section: Main Findings and Discussionmentioning

confidence: 99%

Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance

Abdullahi

Zarazaga

Campaña-Burguet

et al. 2022

Journal of Applied Microbiology

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The molecular ecology of Staphylococcus aureus, Staphylococcus pseudintermedius and their methicillin‐resistant strains in healthy dogs and cats could serve as good models to understand the concept of bacterial zoonosis due to animal companionship. This study aims to provide insights into pooled prevalence, genetic lineages, virulence and antimicrobial resistance (AMR) among healthy dogs and cats. Original research and brief communication articles published from 2001 to 2021 that reported the nasal detection of S. aureus and S. pseudintermedius in healthy dogs and cats in the community, homes and outside veterinary clinics were examined and analysed. Forty‐nine studies were eligible and included in this systematic review. The pooled prevalence of nasal carriage of S. aureus/methicillin‐resistant S. aureus (MRSA) in healthy dogs and cats were 10.9% (95% CI: 10.1–11.9)/2.8% (95% CI: 2.4–3.2) and 3.2% (95% CI: 1.9–4.8)/0.5% (95% CI: 0.0–1.1), respectively. Conversely, the pooled prevalence of S. pseudintermedius/methicillin‐resistant S. pseudintermedius (MRSP) in healthy dogs and cats were 18.3% (95% CI: 17.1–19.7)/3.1% (95% CI: 2.5–3.7) and 1.3% (95% CI: 0.6–2.4)/1.2% (95% CI: 0.6–2.3), respectively. Although highly diverse genetic lineages of S. aureus were detected in healthy dogs and cats, MSSA‐CC1/CC5/CC22/CC45/CC121/CC398 and MRSA‐CC5/CC93/CC22/CC30 were mostly reported in dogs; and MSSA‐CC5/CC8/CC15/CC48 and MRSA‐CC22/CC30/CC80 in cats. Of note, MSSA‐CC398 isolates (spa‐types t034 and t5883) were detected in dogs. Genetic lineages often associated with MSSP/MRSP were ST20/ST71, highlighting the frequent detection of the epidemic European MRSP‐ST71 clone in dogs. S. aureus isolates carrying the luk‐S/F‐PV, tst, eta, etb and etd genes were seldomly detected in dogs, and luk‐S/F‐PV was the unique virulence factor reported in isolates of cats. S. pseudintermedius isolates harbouring the luk‐S/F‐I, seint and expA genes were frequently found, especially in dogs. High and diverse rates of AMR were noted, especially among MRSA/MRSP isolates. There is a need for additional studies on the molecular characterization of isolates from countries with under‐studied nasal staphylococci isolates.

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Section: Main Findings and Discussionmentioning

confidence: 99%

Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance

Abdullahi

Zarazaga

Campaña-Burguet

et al. 2022

Journal of Applied Microbiology

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“…36 S. pseudintermedius was isolated from a patient with hepatocellular carcinoma with a urinary tract infection. 31 S. pseudintermedius was also isolated and identified in complicated urinary tract infections in senior citizens. 33…”

Section: Clinical Presentation Of Infection Caused By Staphylococcus ...mentioning

confidence: 99%

“…29 S. pseudintermedius had been isolated from totally implantable venous access ports (TIVAP), and post-surgery purulent rhinosinusitis. 30,31 Rhinosinusitis, endocarditis, prosthetic joint infection, external ear infection, urinary tract infection, catheter associated bacteremia and surgical site infections caused by S. pseudintermedius in humans have been reported. 4,6,8,19,[32][33][34][35] The organism had been isolated in a patient who had chronic sinusitis and was in close association with dogs.…”

Section: Clinical Presentation Of Infection Caused By Staphylococcus ...mentioning

confidence: 99%

An overview of human infections caused by <em>Staphylococcus pseudintermedius:</em> A zoonotic risk of the oldest friend

Priyantha¹

2022

Sri Lankan J Infec Dis

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Staphylococcus pseudintermedius is colonized in 90% of healthy dogs and the infection has also been reported in humans who have close contact with dogs. S. pseudintermedius is a Gram positive coagulase positive coccus which is an opportunistic pathogen. Human infection has been reported less frequently either due to misidentification or misdiagnosis or to underreporting. The objective of this overview is to highlight the epidemiology, clinical presentation, importance of laboratory tests and antimicrobial resistance of S. pseudintermedius in humans.Human infections of S. pseudintermedius have been reported as case studies or clusters of infections in the literature. Several cases have been reported among the adult population, and in patients with metabolic diseases such as diabetes mellitus, immunocompromised states such as AIDS, cancers, and autoimmune diseases. The organism had been isolated and identified both in healthy people and individuals with adverse clinical outcomes. S. pseudintermedius causes skin and soft tissue infections, catheter associated infections and surgical site infections in humans. The incidence of skin and soft tissue infection by S. pseudintermedius in humans was 0.025% in Canada. Methicillin resistance S. pseudintermedius (MRSP) has been isolated both in healthy people and associated with clinical infections. MRSP is often multidrug resistant and therapeutic options are limited. Multidrug resistance has been detected in methicillin susceptible S. pseudintermedius (MSSP). Close association of a canine host is the major risk factor in humans and vulnerable individuals need to be persuaded to practice hygienic practices to minimize the risk of zoonotic infection.In conclusion, differentiation of S. pseudintermedius from S. aureus is required to understand the epidemiology of the disease, diagnosis, clinical presentation, and further interpretation of antimicrobial resistance in the human clinical context. Suitable hygienic practices post handling of dogs and improvement of laboratory facilities would help minimize the incidence of S. pseudintermedius infections in humans.

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“…The SCC mec II-III hybrid, which is made up parts of previously identified SCC mec types II and III of MRSA, has been reported in S . pseudintermedius [ 36 , 38 ]. A total of 72.8% (75/103) MRSP isolates recovered from canines in North America, Europe, and Asia were reported to harbor the SCC mec II–III hybrid, while the remaining isolates harbored either SCC mec types III, IV, V, VII, or were not typeable [ 39 ].…”

Section: S Pseudintermedius Resistance To Beta-lactams and E...mentioning

confidence: 99%

“…Interestingly, most MRSP isolates recovered from human infections usually harbor the SCCmec III gene. A case of an implanted port catheter system infection caused by MRSP ST71-SCC mec III in a dog owner patient with hepatocellular carcinoma was reported in Japan [ 38 ]. This MRSP ST71-SCC mec III strain is a well-known epidemiological clone mostly isolated from dogs in Asia.…”

Section: S Pseudintermedius Resistance To Beta-lactams and E...mentioning

confidence: 99%

Human Colonization and Infection by Staphylococcus pseudintermedius: An Emerging and Underestimated Zoonotic Pathogen

2023

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S. pseudintermedius is a known resident of the skin and mucous membranes and a constituent of the normal microbiota of dogs. It has also been recognized as an opportunistic and zoonotic pathogen that is able to colonize humans and cause severe diseases, especially in immunocompromised hosts. Most importantly, methicillin-resistant S. pseudintermedius (MRSP), which is intrinsically multidrug-resistant, has emerged with serious public health consequences. The epidemiological situation is further exacerbated with reports of its zoonotic transmission and human infections which have been mostly attributed to the increasing frequency of dog ownership and close contact between dogs and humans. Evidence on the zoonotic transmission of MRSP from pet dogs to humans (such as dog owners, small-animal veterinarians, and other people in close proximity to dogs) is limited, especially due to the misidentification of S. pseudintermedius as S. aureus. Despite this fact, reports on the increasing emergence and spread of MRSP in humans have been increasing steadily over the years since its first documented report in 2006 in Belgium. The emergence of MRSP strains has further compromised treatment outcomes in both veterinary and human medicine as these strains are resistant to beta-lactam antimicrobials usually prescribed as first line treatment. Frustratingly, the limited awareness and surveillance of the zoonotic transmission of S. pseudintermedius have underestimated their extent of transmission, prevalence, epidemiology, and public health significance. In order to fill this gap of information, this review focused on detailed reports on zoonotic transmission, human colonization, and infections by S. pseudintermedius, their pathogenic features, antimicrobial resistance profiles, epidemiology, risk factors, and treatment. In writing this review, we searched Web of Science, PubMed, and SCOPUS databases using the keyword “Staphylococcus pseudintermedius AND humans”. A phylogenetic tree to determine the genetic relatedness/diversity of publicly available genomes of S. pseudintermedius was also constructed.

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Implanted Port Catheter System Infection Caused by Methicillin-resistant <i>Staphylococcus pseudintermedius</i> ST71-SCC<i>mec</i> type III

Cited by 7 publications

References 33 publications

Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance

Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance

An overview of human infections caused by <em>Staphylococcus pseudintermedius:</em> A zoonotic risk of the oldest friend

Human Colonization and Infection by Staphylococcus pseudintermedius: An Emerging and Underestimated Zoonotic Pathogen

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