Implantation of the rat egg. III. Origin and development of primary trophoblast giant cells

Alden, Roland H.

doi:10.1002/aja.1000830106

Cited by 57 publications

(12 citation statements)

References 42 publications

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“…The present study showed swollen endothelium in the arterioles during early postpartum. In accordance with the suggestion of early investigators [2,6], these swollen endothelial cells may change into the giant cells. In addition to the swollen endothelium, lymphocytes closely associated with the endothelium and fusing into a huge nucleus within the endothelium were found.…”

Section: Days 4 Andsupporting

confidence: 90%

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Histological Changes in the Endometrial Arterioles during Postpartum in the Chinese Hamster(Cricetulus griceus).

Ninomiya

Inomata

1998

The Journal of Veterinary Medical Science

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ABSTRACT. The morphology of the uterine wall in the postpartum Chinese hamster (Cricetulus griceus) was studied with particular reference to the changes in the arterioles in the mesometrial endometrium. At day 0 postpartum, the endometrial arterioles were characterized by the appearance of trophoblastic giant cells plugging ruptured arterioles. On days 1 to 3 postpartum, the giant cells were replaced by epitheloid cells. On days 4 to 5 postpartum, the epitheloid cell mass was invaded by fibroblasts to occlude the arterial lumens. On days 6 to 7 postpartum, endometrial regeneration was completed. The giant cell might play a role in hemostasis immediately after parturition. -KEY WORDS: Chinese hamster, endometrial arteriole, postpartum.

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Section: Days 4 Andsupporting

confidence: 90%

“…The endometrial giant cells are now generally recognized to be cells which arise by enlargement of trophoblastic cells [2,6]. The trophoblastic cells are usually found in the decidua of the placenta.…”

Section: Days 4 Andmentioning

confidence: 99%

Histological Changes in the Endometrial Arterioles during Postpartum in the Chinese Hamster(Cricetulus griceus).

Ninomiya

Inomata

1998

The Journal of Veterinary Medical Science

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“…However, the primary trophoblast giant cells develop, initially at least, only from the abembryonic pole of the trophectoderm. This is exactly as described by Alden (1948) (Kirby, 1963) Fig. 5).…”

Section: Methodssupporting

confidence: 75%

Development of the Mouse Blastocyst Transplanted to the Spleen

Kirby¹

1963

Reproduction

111

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“…In muridae rodents, attachment of the blastocysts to the uterine luminal epithelium is followed by invasion of the endometrium by the mural trophoblast cells [2][3][4][5][6][7][8][9]. During the initial stage of invasion, trophoblast cells increase in size and transform into a limited number of nondividing primary giant cells [2,5,10,11], which eliminate the luminal epithelial cells of the uterus and actively phagocytize them [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…During the initial stage of invasion, trophoblast cells increase in size and transform into a limited number of nondividing primary giant cells [2,5,10,11], which eliminate the luminal epithelial cells of the uterus and actively phagocytize them [8,9]. Then the primary giant cells penetrate the basement membrane and invade the lamina propria of the endometrium [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Matrix Proteins and Heparin-Binding Components in Fetal Bovine Serum upon the Proliferation of Ectoplacental Cone Cells in Mouse Blastocysts Cultured in Vitro1

Koi

Tachi

Tojo

et al. 1995

Biology of Reproduction

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Trophoblastic invasion of the endometrium is among the events that are crucial for successful implantation and hemochorial placentation. To understand the mechanism underlying the trophoblastic invasion, we investigated effects of fibronectin substratum and heparin-binding components in fetal bovine serum (FBS) upon trophoblast and ectoplacental cone (EPC) cells derived from mouse blastocysts produced by IVF and cultured in vitro. The results demonstrated that 1) in these blastocysts, contact of EPC cells with fibronectin-coated glass substratum in the presence of FBS triggered an outburst of cell proliferation with the eventual differentiation of the EPC cells into secondary giant trophoblast cells and 2) frequencies of blastocysts that exhibited EPC cell proliferation significantly increased if FO medium (modified Eagle's minimum essential medium) was supplemented with FBS depleted of heparin-binding substances (H-FBS). One possible interpretation of the effect of H-FBS is that free fibronectins or related substances in the serum might interfere with EPC cell proliferation, for which the presence of substratum-bound fibronectin is essential. Alternatively, the serum might contain heparin-binding competitive inhibitors of yet unidentified growth factor(s) necessary for EPC cell proliferation.

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Implantation of the rat egg. III. Origin and development of primary trophoblast giant cells

Cited by 57 publications

References 42 publications

Histological Changes in the Endometrial Arterioles during Postpartum in the Chinese Hamster(Cricetulus griceus).

Histological Changes in the Endometrial Arterioles during Postpartum in the Chinese Hamster(Cricetulus griceus).

Development of the Mouse Blastocyst Transplanted to the Spleen

Effects of Matrix Proteins and Heparin-Binding Components in Fetal Bovine Serum upon the Proliferation of Ectoplacental Cone Cells in Mouse Blastocysts Cultured in Vitro1

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