Implantation of the rat egg. II. Alteration in osmiophilic epithelial lipids of the rat uterus under normal and experimental conditions

Alden, Roland H.

doi:10.1002/ar.1090970102

Cited by 57 publications

(24 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4) orientated in a mesometrialantimesometrial direction. The individual cells are regularly aligned and fat droplets appear in the bases of the cells (Alden, 1947). In the mouse, by the fifth day the microvilli from opposing luminal surfaces are interlocked so that the lumen is closed.…”

Section: Luminal Epitheliummentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

View full text Add to dashboard Cite

Implantation involves the attachment of the blastocyst to the wall of the uterus with, in some cases, the embedding of the entire ovum in the uterine wall. Associated with it are very profound and characteristic changes in the endometrium both during preparation for implantation and following attachment of the blastocyst. In this chapter, the uterine changes that take place during preparation will be considered first and then the changes during the process of implantation. The former occur regularly and frequently throughout the life of most female mammals, whereas the latter are rarer events, especially in women. This division of the subject is also convenient for the consideration of the control mechanism involved. Whereas the preparative changes are largely directed by the varying levels of the hormones secreted by the ovary, once the implantation process has been initiated hormones playa largely permissive role.There is considerable species variation in the reaction of the uterus in preparation for and during implantation. De Feo (1967) reviewed this subject very thoroughly in the first edition of this book. The great majority of research investigations have been carried out on laboratory rodents, with very little on primates or the larger domestic animals. It follows therefore that any general account of implantation will lean heavily on information acquired from laboratory animals. Although one would like to have a much more general coverage, one cannot escape the reality that information acquired from many experiments on large numbers of laboratory animals provides a sound foundation on which to build. Information from primates or wild mammals will always tend to be fragmentary because of the difficulty of obtaining large numbers of specimens. Anyone who has worked with rats or mice knows how easy it is to be misled by the results from two or three animals. The only sensible course therefore is to get as

show abstract

Section: Luminal Epitheliummentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

View full text Add to dashboard Cite

show abstract

“…Alden (17) confirmed that the total lipids in uterus were enhanced by progesterone administration. The increase in total lipids in our experiment is in agreement with the above observation and that of Davis and Alden (5).…”

Section: Discussionmentioning

confidence: 81%

“…In general, oestrogen mostly depletes total lipid at the expense of neutral lipids (15,16,17) and progesterone accumulates total lipids (1,5). When administered together the oestrogenic effect was found to be better pronounced than progesterone.…”

Section: Discussionmentioning

confidence: 95%

“…This suggests that oestrogen profoundly affects uterine lipids. Oestrogen causes rapid disappearance of lipids demonstrable by histochemical techniques (5,6,17) and stimulates metabolic pathways leading to lipid synthe sis particularly phospholipids (12,15,30,33). The increase in phospholipids by oestrogen administration may be due to the oestrogenic stimulation of cellular proliferation where phospholipids serve primarily as structural elements in cellu lar membranes (34).…”

Section: Discussionmentioning

confidence: 99%

“…Uterine tissue is a potent target for the action of sex steroids and hormones have a specific influence on the uterine metabolic activities. Lipid metabolism in the uterus was investigated in different phases of oestrus cycles in rats with reference to insulin, adrenocortical hormones and Manimekalai/Umapathy/Govindarajulu 214 oestrogens (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). However, uterine lipids were suggested to be derived from the Fallopian tubes, or circulatory system or by biosynthesis in the uterus itself (1).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hormonal Influence on Uterine Lipids

Manimekalai¹,

Umapathy²,

Govindarajulu³

1979

Horm Res

View full text Add to dashboard Cite

The effects of oestrogen (OE), progesterone (P) and oestrogen plus progesterone (OEPP) on uterine lipids of adult ovariectomized rats were studied. Administration of gonodal hormones brought about considerable alterations in total lipids, mainly due to an increase in phospholipids and glycerides in the case of OE and P groups. Even though the total cholesterol remained unaltered, a marked alteration in its fractions was evident in all the groups. Oestrogen seems to decrease all the glyceride classes while progesterone induces accumulation of triglycerides with concomitant decrease in mono- and diglycerides. Individual classes of phospholipids show marked alterations in their distribution in all the groups studied.

show abstract

The Hormonal Control of Implantation

Aitken

1979

Novartis Foundation Symposia

View full text Add to dashboard Cite

Implantation of the rat egg. II. Alteration in osmiophilic epithelial lipids of the rat uterus under normal and experimental conditions

Cited by 57 publications

References 21 publications

The Implantation Reaction

The Implantation Reaction

Hormonal Influence on Uterine Lipids

The Hormonal Control of Implantation

Contact Info

Product

Resources

About