Implantation of euploid blastocysts, assessed by array comparative genomic hybridization (aCGH), in unstimulated cycles is not correlated with maternal age

Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes

“…Comprehensive chromosome analysis should result in a better assessment of the number of viable oocytes obtained from a given ovarian stimulation cycle. Chromosomally normal blastocysts, as determined using CGH, quantitative Polymerase Chain Reaction (PCR), or SNP arrays, have been reported to implant with a 60% rate or higher and seldom miscarry in women of advanced maternal age (6,7,(39)(40)(41)(42)(43). It should be possible to determine the number of oocytes required to provide a reasonable chance of live birth using estimates of blastocyst formation rate per euploid oocyte and blastocyst implantation rate in a particular assisted reproductive technology (ART) laboratory.…”