Implantation of a modified stented bovine pulmonary valve in a beating heart sheep model

Zhang, Yongshan; Teng, Fei; Bao, Weiguo; Zhou, Qingling; Sun, Qiang; Meng, Guowei

doi:10.1111/jocs.13185

Cited by 2 publications

(2 citation statements)

References 12 publications

(22 reference statements)

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“…However, pressure gradients across the conduit valve tends to increase over time, which limits the durability in these patients. Percutaneous options using the Melody and modified stented bovine bioprostheses may have a role to play in dealing with these stenotic conduit valves …”

Section: Discussionmentioning

confidence: 99%

Late results of right ventricular outflow tract reconstruction with a bicuspid expanded polytetrafluoroethylene valved conduit

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Late results of right ventricular outflow tract reconstruction with a bicuspid expanded polytetrafluoroethylene valved conduit

et al. 2018

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“…Additionally, growth and remodelling of the heart valve is relatively rapid (within several months in juvenile sheep), meaning that sheep are the FDA-approved pre-clinical, gold standard animal model in translational research for tissue-engineered heart valve replacements [ 79 ]. Sheep pulmonary valve stent models show good structural and functional outcomes, avoiding stent fractures and remaining intact to the pulmonary artery wall under microscopic or radiographic examination [ 80 ]. The latter study validated the implantation of a newly modified, self-expandable “Z” stent valve into the pulmonary position in sheep.…”

Section: The Use Of Sheep To Model Human Diseases In Biomedical Researchmentioning

confidence: 99%

The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders

Banstola

Reynolds

2022

Biology

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An essential aim of biomedical research is to translate basic science information obtained from preclinical research using small and large animal models into clinical practice for the benefit of humans. Research on rodent models has enhanced our understanding of complex pathophysiology, thus providing potential translational pathways. However, the success of translating drugs from pre-clinical to clinical therapy has been poor, partly due to the choice of experimental model. The sheep model, in particular, is being increasingly applied to the field of biomedical research and is arguably one of the most influential models of human organ systems. It has provided essential tools and insights into cardiovascular disorder, orthopaedic examination, reproduction, gene therapy, and new insights into neurodegenerative research. Unlike the widely adopted rodent model, the use of the sheep model has an advantage over improving neuroscientific translation, in particular due to its large body size, gyrencephalic brain, long lifespan, more extended gestation period, and similarities in neuroanatomical structures to humans. This review aims to summarise the current status of sheep to model various human diseases and enable researchers to make informed decisions when considering sheep as a human biomedical model.

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Implantation of a modified stented bovine pulmonary valve in a beating heart sheep model

Abstract: Transventricular implantation of a modified nitinol pulmonary valve stent showed good structural and functional outcomes without stent fracture or migration.

Cited by 2 publications

References 12 publications

Late results of right ventricular outflow tract reconstruction with a bicuspid expanded polytetrafluoroethylene valved conduit

Late results of right ventricular outflow tract reconstruction with a bicuspid expanded polytetrafluoroethylene valved conduit

The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders

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