Implantation in Ovariectomized Mice Treated With Dibutyryl Adenosine 3',5'-Monophosphate (Dibutyryl Cyclic Amp)

Webb, F. T. G.

doi:10.1530/jrf.0.0420511

Cited by 22 publications

(12 citation statements)

References 13 publications

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“…Recently, two groups of workers have succeeded in inducing implantation by the intraluminal injection of cyclic AMP (Webb, 1975;Holmes and Bergstrom, 1975). This is an area in which advances can be expected in the near future.…”

Section: Mode Of Action Of Luteal-phase Estrogen In Inducing Endometrmentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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Implantation involves the attachment of the blastocyst to the wall of the uterus with, in some cases, the embedding of the entire ovum in the uterine wall. Associated with it are very profound and characteristic changes in the endometrium both during preparation for implantation and following attachment of the blastocyst. In this chapter, the uterine changes that take place during preparation will be considered first and then the changes during the process of implantation. The former occur regularly and frequently throughout the life of most female mammals, whereas the latter are rarer events, especially in women. This division of the subject is also convenient for the consideration of the control mechanism involved. Whereas the preparative changes are largely directed by the varying levels of the hormones secreted by the ovary, once the implantation process has been initiated hormones playa largely permissive role.There is considerable species variation in the reaction of the uterus in preparation for and during implantation. De Feo (1967) reviewed this subject very thoroughly in the first edition of this book. The great majority of research investigations have been carried out on laboratory rodents, with very little on primates or the larger domestic animals. It follows therefore that any general account of implantation will lean heavily on information acquired from laboratory animals. Although one would like to have a much more general coverage, one cannot escape the reality that information acquired from many experiments on large numbers of laboratory animals provides a sound foundation on which to build. Information from primates or wild mammals will always tend to be fragmentary because of the difficulty of obtaining large numbers of specimens. Anyone who has worked with rats or mice knows how easy it is to be misled by the results from two or three animals. The only sensible course therefore is to get as

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Section: Mode Of Action Of Luteal-phase Estrogen In Inducing Endometrmentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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“…Holmes & Bergstrom (1975) and Webb (1975b) respectively have demonstrated that cyclic AMP and dbcAMP can precipitate implantation in mice maintained in experimental diapause. Ebert & Fox (1977) have observed a simUar effect using cyclic GMP in the rat.…”

Section: The Interaction Between Embryo and Endometrium At Implantationmentioning

confidence: 99%

Hormone involvement in the establishment of pregnancy

Sauer¹

1979

Reproduction

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“…A group of female rats received the same volume of PBS and served as control rats. The procedure has been described in detail elsewhere (Webb, 1975).…”

Section: Hormonal Regimenmentioning

confidence: 99%

“…An injection of dbcAMP, instead of oestradiol, to ovariectomized pregnant mice given progesterone alone induces embryo implantation (Webb, 1975). Blastocyst implantation provides a critical test for the action of the cyclic nucleotide, since a stringent sequence of progesterone and oestradiol action is required for uterine functional differentiation at this time (Psychoyos, 1973) and the apparently oestrogen-like effects of the nucleotide result in specific physiolo¬ gical events (Webb, 1975(Webb, , 1977. Oestradiol stimulates synthesis and secretion of uterine specific proteins in the lumen and these apparently regulate blastocyst cell metabolism before implantation (Surani, 1975(Surani, ,1976(Surani, ,1977.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dibutyryl Cyclic Amp and Oestradiol on Incorporation of [3h]leucine Into the Proteins of Luminal Fluid of the Rat Uterus

Surani¹,

Webb²

1977

Journal of Endocrinology

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An injection of 12-5 nmol dibutyryl cyclic AMP (dbcAMP) into each uterine horn of ovariectomized rats maintained on progesterone alone, enhanced incorporation of [3H]leucine into uterine luminal proteins. A value of 11-73 X 10(3) c.p.m. [3H]leucine incorporated/rat was found after injection of dbcAMP compared with 3-69 X 10(3) c.p.m./rat after injection of saline. An injection of 1-0 microgram oestradiol, in contrast, gave 58-05 X 10(3) c.p.m./rat. Electrophoretic analysis showed that the radioactively labelled proteins found after an injection of dbcAMP or oestradiol were qualitatively similar to those detected on day 5 of pregnancy, the day of blastocyst implantation. The nucleotide thus apparently elicits a uterine response similar to that observed after an injection of oestradiol.

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Implantation in Ovariectomized Mice Treated With Dibutyryl Adenosine 3',5'-Monophosphate (Dibutyryl Cyclic Amp)

Cited by 22 publications

References 13 publications

The Implantation Reaction

The Implantation Reaction

Hormone involvement in the establishment of pregnancy

Effect of Dibutyryl Cyclic Amp and Oestradiol on Incorporation of [3h]leucine Into the Proteins of Luminal Fluid of the Rat Uterus

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