Implantation, deciduoma formation and live births in mast cell-deficient mice (W/Wv)

Wordinger, Robert J.; Jackson, Fred L.; Morrill, A.

doi:10.1530/jrf.0.0770471

Cited by 36 publications

(16 citation statements)

References 9 publications

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“…Although mast cells are present at low numbers in the normal female reproductive tract and their appearance is regulated with the estrous cycle, a role for these cells in reproduction is presently unclear. Clearly, mast cells are not essential for pregnancy, as live offspring have been produced in mast cell deficient, W/W" mice after transplantation of wild-type donor blastocysts (Wordinger et al 1986). However, it is possible that abnormal accumulations of mast cells in the female reproductive tract could affect the maternal recognition of pregnancy or embryonic development.…”

Section: Discussionmentioning

confidence: 99%

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.

Bedell¹,

Brannan²,

Evans³

et al. 1995

Genes Dev.

135

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The Steel (SI) locus is essential for the development of germ cells, hematopoietic cells, and melanocytes and encodes a growth factor (Mgf) that is the ligand for c-kit, a receptor tyrosine kinase encoded by the W locus. We have identified the molecular and germ cell defects in two mutant SI alleles, Steel-panda (SP '~) and Steel-contrasted (SiC~ that cause sterility only in females. Unexpectedly, both mutant alleles are shown to contain DNA rearrangements, located >100 kb 5' of Mgf-coding sequences, that lead to tissue-specific effects on Mgf mRNA expression. In S/v~ embryos, decreased Mgf mRNA expression in the gonads causes a reduced number of primordial germ cells in both sexes. However, Mgf expression and spermatogenesis in the postnatal mutant testes is normal, and spermatogonial proliferation compensates for deficiencies in germ cell numbers. In S/pa~ and S1 ~~ homozygous females, decreased Mgf mRNA expression causes sterility by affecting the initiation and maintenance of ovarian follicle development. Thus, regulated expression of Mgf is required for multiple stages of embryonic and postnatal germ cell development. Surprisingly, other areas of the S1 ~~ female reproductive tract displayed ectopic expression of Mgf mRNA. We propose that the SP '~" and SI ~~ rearrangements alter Mgf mRNA abundance through position effects on expression that act at a distance from the SI gene.

show abstract

Section: Discussionmentioning

confidence: 99%

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.

Bedell¹,

Brannan²,

Evans³

et al. 1995

Genes Dev.

135

View full text Add to dashboard Cite

show abstract

“…However, the increment of the uterine histamine levels in MC-deficient WBB6F 1 -W/W V (W/W V ) after steroid treatment (Wordinger et al, 1985) suggests an alternative source of histamine like endothelial cells (Robinson-White et al, 1982) or/and decidual cells which have been shown to release histamine upon stimulation (Schrey et al, 1995). A study from Wordinger et al (1986) makes the discussion even more controversial. The sterility of MC-deficient WBB6F-W/W V is mainly due to atrophic ovaries with a hyperplastic stroma and absence of follicles and distinct corpora lutea (Wordinger et al, 1985).…”

Section: Mast Cells Are Important For Induction and Maintenance Of Prmentioning

confidence: 99%

Mast cells as novel mediators of reproductive processes

2013

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The relationship between mast cells (MCs) and pregnancy is a controversially discussed topic. The presence and quantitative distribution of MCs in the reproductive tract was confirmed in different species. A phase-dependent oscillation of MCs during the hormonal regulated estrous cycle was suggested and on this basis, MCs were assumed to play a positive role in implantation because of their ability to secrete histamine. At later pregnancy stages, they were proposed to have rather a negative role, as their exacerbated activation is associated with pre-term delivery. The present review is intended to provide an overview about uterine MCs that bring to light their unexpected relevance for reproductive processes.

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“…Neutrophils and monocytes circulate throughout the maternal placental vasculature and have been shown to infiltrate areas of infection, damage, or resorption [Girardi 2008;Girardi et al 2003;Rogerson et al 2003]. Lastly, mast cells have been reported to exist within the murine myometrium during normal pregnancy [Wordinger et al 1986] and in greater numbers in the decidua during abortion [Widayati et al 2004]. In humans, increased numbers of mast cells in the uterus are associated with failed pregnancies [Arck et al 2001;Marx et al 1999].…”

Section: Immunology Of Pregnancymentioning

confidence: 99%

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

Detmar

Jurisicova

2010

Systems Biology in Reproductive Medicine

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Polycyclic aromatic hydrocarbons (PAHs) are released into the environment as a result of incomplete fossil fuel combustion from industrial furnaces, woodburning stoves, and automobile exhaust fumes; however, the primary source of human exposure to these compounds is cigarette smoke. Embryonic and fetal loss after treatment with high doses of PAHs have been well documented in animal studies; however, few studies have addressed the reproductive consequences of long-term, low-level exposure to these chemicals. We previously reported that low doses of PAHs administered to ICR mice over a period of 9 weeks prior to conception resulted in early embryonic resorptions, whereby treated dams lost approximately 50% of their litter. During the course of these studies, we observed greater numbers of infiltrating uterine natural killer (uNK) cells into the placenta of PAH-exposed conceptuses. While exposure to high levels of PAHs has been shown to be immunosuppressive, increasing evidence suggests that chronic, low-dose exposure to PAHs may stimulate immune cells. Thus, we hypothesized that low-dose, chronic PAH exposure in our mouse model is mediating embryonic resorption by hyperstimulating maternal immune cells. In this review of the literature, we outline the rationale of our argument and present preliminary data, focussing upon PAH-mediated alterations in uNK cell dynamics and how these changes may be linked to early embryonic resorptions.

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Implantation, deciduoma formation and live births in mast cell-deficient mice (W/Wv)

Cited by 36 publications

References 9 publications

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.

Mast cells as novel mediators of reproductive processes

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

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