Implantation: Cell biology of embryo penetration route revisited

Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis

“…Despite recent innovations in ovarian stimulation protocols (28,29), reproductive immunology (30,31), and reproductive surgery (32,33), implantation remains the main limiting factor of IVF success (34,35). The implantation process encompasses different stages (endometrial decidualization, embryo apposition, adhesion, penetration, and trophoblast invasion) that are finely regulated by immune cells and cytokines (36)(37)(38).…”

Twenty Years on for The Epithelial-Mesenchymal Transition International Association (TEMTIA): An Interview with Co-Founders Erik Thompson and Donald Newgreen

“…This also initiated quite a number of follow-up studies, diving more deeply into the secrets of the cellular processes going on in these two interacting systems, in my lab and later on also in others. In my lab, the leading idea was that the interacting partners, trophoblast and uterine epithelium, make use of certain elements of an EMT program leading to changes in cell behaviour [Denker, 1993[Denker, , 2016. Similar work from other labs concentrated just on aspects of epithelial membrane properties [Murphy, 2004].…”

“…These epithelial cells do not give up their epithelial nature completely; that would be much too dangerous. What is going on at embryo implantation appears to be that the two interacting systems, that of the invading trophoblast and that of the maternal host tissue, apply just certain parts of EMT processes [Denker, 1993[Denker, , 2016.…”