Implantation capacity of endometry of veteran women, with contusion in anamnesis, with unrealized reproductive function

Kaminskiy, V.V.; Суслікова, Л.В.; Serbeniuk, A. V.

doi:10.15574/hw.2020.155-156.44

Cited by 3 publications

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“…Безпліддя залишається однією з найважливіших медичних і соціальних проблем не тільки в Україні, але й у всьому світі [7,10,12,23]. За даними Всесвітньої організації охорони здоров'я, безплідний шлюб, частота якого щороку збільшується на 10 млн випадків, впливає на демографічні показники більш негативно, ніж невиношування вагітності та перинатальні втрати [4,13,14,17].…”

Section: вступunclassified

“…Після дегідратації зразки ендометрія заливали в парафін за стандартною методикою. На ротаційному мікротомі Microm HM325 з системою переносу зрізів STS ("Carl Zeiss", Німеччина) виготовляли серійні гістологічні зрізи товщиною 3-4 мкм, які потім фарбували гематоксиліном та еозином [14,23]. Для імуногістохімічного дослідження зрізи поміщали на покриті адгезивом скло Super Frost Plus ("Menzel", Німеччина).…”

Section: матеріали та методиunclassified

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Uterine natural killer cells during the implantation window period in women veterans experienced by injury with unrealished reproductive function

Serbeniuk¹

2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Against the background of stress and post-traumatic stress disorder (PTSD) in women, changes in the hormonal background improve – the levels of stress hormones and the morphofunctional endometrium, which in their change negatively affect the reproductive health of women in Ukraine. The purpose of this study was to increase the efficiency of diagnosis and treatment of pathology and implantation capacity of the endometrium in women of reproductive age who took part in hostilities and suffered a concussion. Uterine natural killer cells were studied during the implantation window in 487 women of reproductive age who participated in combat operations and suffered concussions, who underwent hysteroscopy with endometrial sampling for histological examination and scanning electron microscopy on the 21st day of menstruation cycle (MC). Of these women, 246 patients – the comparison group – of reproductive age with a history of trauma without post-concussive syndrome and 211 in the main group, women of reproductive age who have consequences of concussion in the form of post-concussive syndrome. 30 conditionally healthy civilian women of reproductive age served as controls. The average age of the examined was 37.08±4.23 years. The period of stay in the combat zone is 60.26±42.21 months, the time since receiving a traumatic brain injury (concussion) is 18.8±9.2 months. Instrumental examination of women included hysteroscopy. The spectrum of MNC cells (CD16+ and CD56+) in the stroma of the endometrium on the 21st day of MC was determined. Microscopy of the preparations and all morphometric studies were performed on an Olympus AX70 Provis microscope (Olympus, Japan) using the image analysis program Analysis 3.2 Pro (Soft Imaging, Germany) according to the recommendations of the software manufacturer. The obtained results were processed using the Statistica 6.0 and Biostat software packages and methods of analytical statistics. It is established that in women military servicemen, participants in combat operations who suffered a concussion, the content of CD56+ and CD16+ cells in the stroma of the endometrium in women with post-concussion syndrome is greater than that in patients without post-concussion syndrome: in the endometrium, which corresponds to the proliferation phase, it is 1.45 (p<0.0001) and 1.64 times (p<0.0001), in the endometrium, which corresponds to the early secretion phase, 1.93 (p<0.0001) and 2.22 (p<0,0001), in the endometrium, which corresponds to the middle phase of secretion, – in 1.61 (p<0.0001) and in 3.42 (p<0.0001), in chronic endometritis – in 1.92 (p<0 .0001) and 1.94 (p<0.0001), with SAHE – in 1.79 (p<0.0001) and 1.51 (p<0.0001), with endometrial polyps – in 1, 60 (p<0.0001) and at 1.56 (p<0.0001). This study proves the need to improve the efficiency of diagnosis and treatment of endometrial pathology in women of reproductive age who participated in hostilities and suffered concussions.

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Section: матеріали та методиunclassified

Uterine natural killer cells during the implantation window period in women veterans experienced by injury with unrealished reproductive function

Serbeniuk¹

2023

Rep. of Vinnytsia Nation. Med. Univ.

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“…Over the past few years, the population of Ukraine has faced a number of traumatic events: large-scale coups, a change of power, annexation of territories, and war. All these events continue to have a negative impact on the daily life of all Ukrainians, causing constant anxiety, tension and frustration, as well as an increase in the frequency and severity of stress disorders [12].…”

Section: Introductionmentioning

confidence: 99%

“…There is an opinion that disruption of apoptosis processes is of fundamental importance in hyperproliferative processes and cancerous regeneration of cells [12,17,19,21]. Determining the signs that indicate a violation of cell death at the stage of endometrial hyperplasia can make it possible to predict the adverse course of the disease in a timely manner and choose the optimal individual treatment tactics aimed at preserving and restoring the generative function in women of reproductive age and preventing malignancy [7,11,19,20].…”

Section: Introductionmentioning

confidence: 99%

Determination of the proliferative activity of the endometrium during the period of the implantation window in veteran women of reproductive age with a history of contusion

Serbeniuk

2023

Rep. of Morph.

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Today, more than 50.000 women serve in the Armed Forces of Ukraine. The number of people with post-traumatic stress disorder is 27.7 % among military personnel who took part in active combat operations. Post-traumatic syndrome is a frequent predictor of various states of proliferative activity of the endometrium in veteran women of reproductive age with changes in the hormonal background, morphofunctional changes of the endometrium, which in turn negatively affects the reproductive health of women. The purpose of the work: to determine the proliferative activity of the endometrium in patients of reproductive age who took part in hostilities and suffered a concussion. The selection criteria of the women included in the study were: the presence of contusion in the anamnesis, normospermia in the husband, the absence of pregnancy within a year after putting the main disease into remission, and unfulfilled reproductive plans. The age of the examined women ranged from 20 to 40 years. 457 women who took part in combat operations and suffered concussions were examined. The criterion for inclusion in the main group (O) was post-concussive syndrome as a consequence of a concussion sustained during hostilities. The number of examinees was 211 women. The criterion for inclusion in the comparison group (P) (n=246 women) was a concussion during combat operations, but the absence of post-concussion syndrome. The control group (K) included 30 civilian women without episodes of any trauma in the anamnesis. Clinical, instrumental and morphological research methods were used during the research. The most significant differences in the number of immunopositive endometrial cells in the state of proliferation and apoptosis were noted between groups P and O in chronic endometritis and simple atypical hyperplasia of the endometrium. Thus, in the structure of the endometrium of women with reproductive plans who participated in hostilities with episode of contusion in anamnesis, an increase in the proliferation processes in the glands and stroma of the endometrium against the background of intensification of the processes of apoptosis in the stroma and a decrease in the processes of apoptosis in the glands, which may interfere with the normal course of adhesion, was characteristic blastocysts and trophoblast invasions during implantation.

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Features of mental and reproductive health, functional state of the organism of female military servicemen who suffered concussion during combat actions

Serbeniuk

2023

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Research objectives: establishing an association between the state of mental health, the functional state of body systems, clinical and anamnestic data on reproductive health in female combat participants who suffered a concussion.Material and methods. The study included 487 women of reproductive age who took part in hostilities and suffered a concussion and who were divided into 2 groups – the main group (211 women with post-concussion syndrome) and a comparison group (246 women without the post-concussion syndrome). The control group included 30 healthy civilian women of reproductive age without any trauma episodes in the anamnesis. Concussion symptoms were determined by Cicerone K.D., PCL, Wein, Spielberger – Hanin, Beck questionnaires.Results. The participants of the main group and the comparison group were comparable in terms of age, social status, anthropometric data, parameters of menstrual, ovulatory and reproductive functions, gynecological, somatic and infectious diseases. Patients with post-concussion syndrome have a duration of menstruation 1.07 times (p < 0.001) longer compared to women without post-concussion syndrome; painful menstruation in 1.47 times more often (p < 0.0001), heavy menstruation in 1.64 times (p < 0.003) more often. The infertility duration in patients with post-concussion syndrome is 1.29 times longer (p < 0.0001) compared to women without post-concussion syndrome. 69.27% of women who took part in hostilities and suffered a concussion have a history of ureaplasmosis or bacterial vaginosis: chlamydia and bacterial vaginosis occur in every third patient, ureaplasmosis in 41.61% patients. Chlamydia trachomatis is detected in patients with post-concussion syndrome 1.64 times (p < 0.0007) more often than in patients without this syndrome.Conclusions. Women who suffered concussions during hostilities have significant problems with physical and mental health due to the impact of brain injury and stress factors associated with military actions. Solving this problem requires the development of a comprehensive program that will include medical and psychological support for female military personnel and creation of high-quality medical and psychological rehabilitation of female veterans aimed at their full adaptation to peaceful life.

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Implantation capacity of endometry of veteran women, with contusion in anamnesis, with unrealized reproductive function

Cited by 3 publications

References 0 publications

Uterine natural killer cells during the implantation window period in women veterans experienced by injury with unrealished reproductive function

Uterine natural killer cells during the implantation window period in women veterans experienced by injury with unrealished reproductive function

Determination of the proliferative activity of the endometrium during the period of the implantation window in veteran women of reproductive age with a history of contusion

Features of mental and reproductive health, functional state of the organism of female military servicemen who suffered concussion during combat actions

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