Implantation-associated proteinase in mouse uterine fluid

Pinsker, M. Craig; Sacco, Anthony G.; Mintz, Beatrice

doi:10.1016/0012-1606(74)90007-4

Cited by 63 publications

(29 citation statements)

References 12 publications

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“…Possible functions might be to facilitate such escape by weakening the zona around the blastocyst, to dissolve a discarded zona remaining in a position where it might interfere with implantation, andlor to play some other role in the implantation process. Studies in other mammals have provided evidence (which was sometimes circumstantial) for the involvement of proteinases of trophoblastic andlor uterine origin in the dissolution of extracellular embryonic coats and, in several species, in the initiation of implantation as well (Pinsker et al, 1974;Denker, 1977Denker, ,1980Denker, ,1983 et al., 1978;Denker and Tyndale-Biscoe, 1986;Perona and Wassarman, 1986;Yamazaki and Kato, 1989).…”

Section: Discussionmentioning

confidence: 95%

Implantation, development of the fetal membranes, and placentation in the captive black mastiff bat, Molossus ater

Rasweiler

1990

Am. J. Anat.

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Uterine events during pregnancy were examined histologically in laboratory-bred black mastiff bats (Molossus ater) as part of an effort to develop this species as a model for studies of the factors controlling trophoblastic growth. Embryos entered the uterus at the morula stage and in most cases shed their zonae pellucidae reasonably intact, apparently as blastocyst expansion occurred. Implantation was superficial and observed to occur only in the right uterine horn. During implantation to the endometrium by both blastocyst expansion and closure of the uterine lumen. A decidual reaction was evident at an early stage of uterine epithelial displacement and spread rapidly through the endometrium. Initial trophoblastic proliferation occurred along the uterine lumen and into the glands, while its invasion of the endometrial stroma was delayed. Although one or several primordial cavities have been observed to develop within the epiblast during implantation, these subsequently opened to a trophoepiblastic cavity, and the definitive amnion was formed by folding. A choriovitelline placenta was present briefly at thesomite stage, but disappeared as the exocoelom enlarged and the yolk sac collapsed. The latter persisted through pregnancy, however, as a glandular-appearing body. As the yolk sac retracted from the chorion, it was replaced by allantoic mesoderm, creating a diffuse labyrinthine endotheliodichorial placenta. This was prominent during mid-gestation, but was supplanted by the discoidal hemochorial placenta as the major site of feto-maternal exchange during late pregnancy.

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Section: Discussionmentioning

confidence: 95%

Implantation, development of the fetal membranes, and placentation in the captive black mastiff bat, Molossus ater

Rasweiler

1990

Am. J. Anat.

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“…Discussions are going on as to what extent hardening of the 'zona' should be of concern in human IVF-ET [De Vos and Van Steirteghem, 2000;Magli et al, 1998]. There is ample evidence from studies in various animal systems, notably the rabbit and the mouse, that proteinase systems (of the trophoblast as well as the uterus) are involved in hatching of the blastocysts by causing weakening and at least partial dissolution of the coats, with most data being available for the rabbit [for review, see Denker, 1977;Denker et al, 1989] and the mouse and rat [Dabich and Andary, 1976;Hoversland and Weitlauf, 1982;Menino and O'Claray, 1986;Mintz, 1972;Perona and Wasserman, 1986;Pinsker et al, 1974;Rosenfeld and Joshi, 1981;Yamazaki et al, 1994; with respect to the unclear role of the plasminogen activator-plasmin system, see Carroll et al, 1993;Liedholm and Åstedt, 1975]. Whether comparable proteinase systems are also involved in human blastocyst hatching is unknown but would appear quite probable.…”

Section: Embryonic Coats Implantation and Local Signalingmentioning

confidence: 99%

Structural Dynamics and Function of Early Embryonic Coats

Denker¹

2000

Cells Tissues Organs

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The extracellular embryonic coats (embryo/blastocyst coverings) that surround early mammalian embryos are most often still referred to as zona pellucida. Accumulating evidence from a number of earlier and recent studies clearly indicates that this is an oversimplification which cannot be defended anymore, at least in many species. Structural modifications of the coats occur during cleavage and blastocyst stages; these are most obvious in a number of species with the central type of implantation and, related to this, a high degree of blastocyst expansion, notably the rabbit and the horse. In this contribution, formation and transformation of the various layers of coats (zona pellucida, mucoprotein layer, neozona and gloiolemma in the rabbit, capsule in the horse) will be reviewed, as will be comparable structures seen, e.g., in the fur seal (subzonal layer) and the baboon. These phenomena will be discussed in the context of structurally more subtle changes found in other species, including those with small blastocysts and other types of implantation, in particular with biochemical modifications which may be physiologically quite important. The molecular mechanisms of deposition of coats and their transformation and shedding/dissolution will be briefly addressed. The possible functional significance of the coats and their transformation will be discussed (mechanical, morphogenetic and immunological role, molecular transport control, blastocyst positioning, implantation, trap and reservoir function for signalling molecules).

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“…After Mintz (1972) and Pinsker et al (1974) first suggested that the enzyme responsible for hatching might also be an implantation initiation factor, Gonzales and Bavinster (1995) predicted that the enzyme responsible for focal hatching in vitro might really be the enzyme responsible for facilitating blastocyst attachment and invasion. Through our discovery of ISP1, we have confirmed this additional role for the hatching enzyme in facilitating implantation competence.…”

Section: Discussionmentioning

confidence: 99%

A novel murine tryptase involved in blastocyst hatching and outgrowth

O'Sullivan¹

2001

Reproduction

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ResearchBefore implantation the blastocyst is maintained within a proteinaceous coat, the zona pellucida, which prevents polyspermy and ectopic pregnancy. An extracellular trypsin-like activity, which is necessary for hatching from the zona pellucida in vitro, is localized to the abembryonic pole of the blastocyst. Upon hatching, the extracellular matrix-degrading proteinases urokinase plasminogen activator (uPA) and matrix metalloproteinase 9 (MMP-9) are thought to promote blastocyst invasion. However, gene disruption experiments have demonstrated that uPA and MMP-9 are dispensable and, thus, that other key enzymes are involved in implantation. In this study, a novel implantation serine proteinase (ISP1) gene, which is distantly related to haematopoietic tryptases and represents a novel branch of the S1 proteinase family, was cloned. ISP1 is expressed throughout morulae and blastocysts during hatching and outgrowth. Abrogation of ISP1 mRNA accumulation using antisense oligodeoxynucleotides disrupts blastocyst hatching and outgrowth in vitro. The results of this study indicate that the ISP1 gene probably encodes the long sought after 'hatching enzyme' that is localized to the abembryonic pole during hatching in vitro. ISP1 is the earliest embryo-specific proteinase to be expressed in implantation and may play a critical role in connecting embryo hatching to the establishment of implantation competence at the abembryonic pole of the blastocyst.

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Implantation-associated proteinase in mouse uterine fluid

Cited by 63 publications

References 12 publications

Implantation, development of the fetal membranes, and placentation in the captive black mastiff bat, Molossus ater

Implantation, development of the fetal membranes, and placentation in the captive black mastiff bat, Molossus ater

Structural Dynamics and Function of Early Embryonic Coats

A novel murine tryptase involved in blastocyst hatching and outgrowth

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