Implantation and testing of a novel episcleral pressure transducer: A new approach to telemetric intraocular pressure monitoring

Mariacher, Siegfried; Ebner, Martina; Hurst, José; Szurman, Peter; Januschowski, Kai

doi:10.1016/j.exer.2017.10.020

Cited by 7 publications

(6 citation statements)

References 22 publications

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Section: Implantable and Noninvasive Iop Monitoringmentioning

confidence: 99%

“…Currently, some commercial sensors have been combined with telemetry technology to implant in the eyes of animals and patients for IOP monitoring and biocompatibility investigations. [ 29,30,44,51,101 ] The implanted capacitive IOP sensor was integrated with an inductive coil that was coupled with an external handheld reading device for data communication and power supply at the radio frequency of 13.56 MHz within a distance of 5 cm (Figure 5J). Szurman et al.…”

Section: Implantable and Noninvasive Iop Monitoringmentioning

confidence: 99%

“…Szurman et al. investigated the suprachoroidal [ 101 ] and episcleral [ 44 ] pressure transducer for telemetric IOP monitoring, respectively. The pressure transducer from Implandata Ophthalmic Products GmbH (Germany) composed of six capacitive sensors was integrated with an ASIC that was surrounded by metal coils for wireless data communication and power supply (Figure 5I).…”

Section: Implantable and Noninvasive Iop Monitoringmentioning

confidence: 99%

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Recent progress of continuous intraocular pressure monitoring

et al. 2021

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Glaucoma, a chronic optic neuropathy, is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) has been considered to be the major contributor to glaucoma for a long time and is currently proved to be the only modifiable risk factor for the progression of optic neuropathy. IOP fluctuates throughout the day with a circadian rhythm change and is affected by body gesture changes. Moreover, the IOP spike usually occurs at night or in the early morning. Therefore, the current clinical practice of single and static measurements of IOP during office hours is not conducive to the early diagnosis and treatment of glaucoma. This review focuses on current advances in implantable and noninvasive IOP sensors for obtaining 24‐hour continuous IOP profiles. The content summarizes and classifies IOP sensors based on their working principles and provides representative examples of the sensors for IOP monitoring. Finally, the review further analyzes the challenges of current IOP sensors for clinical practice and puts forward the prospect of IOP sensors in the future.

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Section: Implantable and Noninvasive Iop Monitoringmentioning

confidence: 99%

Section: Implantable and Noninvasive Iop Monitoringmentioning

confidence: 99%

Section: Implantable and Noninvasive Iop Monitoringmentioning

confidence: 99%

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Recent progress of continuous intraocular pressure monitoring

et al. 2021

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“… 19 Encapsulation of MEMS sensors within a thin coating or cladding is a commonly used protection method. 16 , 20 − 29 This involves the application of an ultrathin nonmetallic or metallic coating, including ceramic materials, alloys, and polymers (e.g., parylene, polyimide, and polydimethylsiloxane). For example, in 2018, Tai’s group proposed an encapsulation method based on a combination of parylene and silicon oil coating.…”

Section: Introductionmentioning

confidence: 99%

“…Proper encapsulation is essential to guarantee that implantable MEMS pressure sensors function in vivo with robustness, reliability, biocompatibility, and minimal performance decline . Encapsulation of MEMS sensors within a thin coating or cladding is a commonly used protection method. ,− This involves the application of an ultrathin nonmetallic or metallic coating, including ceramic materials, alloys, and polymers (e.g., parylene, polyimide, and polydimethylsiloxane). For example, in 2018, Tai’s group proposed an encapsulation method based on a combination of parylene and silicon oil coating. ,, They immersed the encapsulated pressure sensor with a zero-drift error of ∼2 mmHg in saline solution at 77 °C for 106 days, while the encapsulation is ∼0.8 mm thick, not negligible compared to the sensor size of ∼2.5 × 2.5 × 0.8 mm 3 .…”

Section: Introductionmentioning

confidence: 99%

Ultrathin and Robust Micro–Nano Composite Coating for Implantable Pressure Sensor Encapsulation

et al. 2020

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Implantable pressure sensors enable more accurate disease diagnosis and real-time monitoring. Their widescale usage is dependent on a reliable encapsulation to protect them from corrosion of body fluids, yet not increasing their sizes or impairing their sensing functions during their lifespans. To realize the above requirements, an ultrathin, flexible, waterproof while robust micro–nano composite coating for encapsulation of an implantable pressure sensor is designed. The composite coating is composed of a nanolayer of silane-coupled molecules and a microlayer of parylene polymers. The mechanism and principle of the composite encapsulation coating with high adhesion are elucidated. Experimental results show that the error of the sensors after encapsulation is less than 2 mmHg, after working continuously for equivalently over 434 days in a simulated body fluid environment. The effects of the coating thickness on the waterproof time and the error of the sensor are also studied. The encapsulated sensor is implanted in an isolated porcine eye and a living rabbit eye, exhibiting excellent performances. Therefore, the micro–nano composite encapsulation coating would have an appealing application in micro–nano-device protections, especially for implantable biomedical devices.

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Implantable self‐aligning fiber‐optic optomechanical devices for in vivo intraocular pressure‐sensing in artificial cornea

Hui

Shtyrkova

Zhou

et al. 2020

Journal of Biophotonics

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Artificial cornea is an effective treatment of corneal blindness. Yet, intraocular pressure (IOP) measurements for glaucoma monitoring remain an urgent unmet need. Here, we present the integration of a fiber‐optic Fabry‐Perot pressure sensor with an FDA‐approved keratoprosthesis for real‐time IOP measurements using a novel strategy based on optical‐path self‐alignment with micromagnets. Additionally, an alternative noncontact sensor‐interrogation approach is demonstrated using a bench‐top optical coherence tomography system. We show stable pressure readings with low baseline drift (<2.8 mm Hg) for >4.5 years in vitro and efficacy in IOP interrogation in vivo using fiber‐optic self‐alignment, with good initial agreement with the actual IOP. Subsequently, IOP drift in vivo was due to retroprosthetic membrane (RPM) formation on the sensor secondary to surgical inflammation (more severe in the current pro‐fibrotic rabbit model). This study paves the way for clinical adaptation of optical pressure sensors with ocular implants, highlighting the importance of controlling RPM in clinical adaptation.

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Implantation and testing of a novel episcleral pressure transducer: A new approach to telemetric intraocular pressure monitoring

Cited by 7 publications

References 22 publications

Recent progress of continuous intraocular pressure monitoring

Recent progress of continuous intraocular pressure monitoring

Ultrathin and Robust Micro–Nano Composite Coating for Implantable Pressure Sensor Encapsulation

Implantable self‐aligning fiber‐optic optomechanical devices for in vivo intraocular pressure‐sensing in artificial cornea

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