Implantate in der Mittelohrchirurgie

G, Geyer

doi:10.1007/978-3-642-84669-4_11

Cited by 26 publications

(40 citation statements)

References 176 publications

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“…Every material combines different advantages and drawbacks with regard to its biocompatibility, integration, plasticity, and physical behavior. Bioverit Õ is a bioglass ceramic, which exists in four different types (I-IV) [5]. Bioverit Õ II, a glass-mica ceramic, is easily machined, highly biocompatible and shows no signs of biodegradation.…”

Section: Introductionmentioning

confidence: 99%

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

et al. 2008

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The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit Õ II which is coated with a silica-nanostructure or with plain Bioverit Õ II as a control. After 2, 6, and 12 weeks, 4 mice per group are sacrificed and both complete petrous bones are analyzed histologically. All implants revealed in situ an incipient growth of thin connective tissue layers over the surface, followed by a *Author to whom correspondence should be addressed. E-mail: Brandes.gudrun@mh-hannover.de spreading of epithelial cells. The osseogenic response which is increasing with time is more intense in the coated Bioverit Õ II specimens. The absence of inflammatory cells suggests an excellent biocompatibility of the silica nano structure. As the results are comparable to a study with the same materials in rabbits, the mouse model described is highly suitable for evaluation of new ossicular replacement materials. Additionally, by gene expression analysis a more detailed insight into cellular interactions of the middle ear is offered.

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Section: Introductionmentioning

confidence: 99%

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

et al. 2008

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“…Ceravital ist eine porenlose oberflä-chenaktive Glaskeramik aus amorphem Silikatphosphat, die als eine der ersten Keramiken für den Gehörknöchelchen-ersatz und als Gehörgangsprothese verwendet wurde [13,31]. Bei Gewebekontakt entwickelt sich nach Natriumionenabgabe und Wasserionenaufnahme ein siliziumoxidreicher Gelfilm.…”

Section: Bioaktive Glaskeramik (Ceravital)unclassified

“…In der Mund-Kiefer-Gesichts-Chirurgie und in der Ohrchirurgie wird Hydroxylapatit [32] z.B. als Ossikelersatz oder zur Rekonstruktion der hinteren Gehörgangswand genutzt [13,19] 7-7,5, obgleich sich die gegenüber physikalischen und chemischen Noxen wenig empfindlichen Keime auch in einem Bereich zwischen 4-9 vermehren lassen [8,29]. Der Keim ist bei Mittelohrentzündungen (auch bei Mischinfektionen) häufig anzüchtbar.…”

Section: Hydroxylapatitunclassified

Zur Beeinflussung des Bakterienwachstums durch alloplastische Knochenersatzmaterialien

Schott

Schwarzkopf³

1999

HNO

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Our findings showed that V-O CEM, bioactive glass ceramic and hydroxyapatite exhibited material-dependent bacterial colonization and thus resembled polymeric bone substitutes (susceptible to invasion by S. epidermidis) and metals (sensitive to S. aureus). In general, users of bone substitutes should conduct preclinical tests in order to obtain advance information on the properties of possible replacement material. Since there can be varying interactions between the materials studied and bacterial growth, material-specific effects on bacterial growth should be investigated. While it is recognized that in vitro studies are an inadequate simulation of the clinical situation, they still provide some insight into the likely behavior of a bone substitutes in human sites.

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“…In einer retrospektiven offenen klinischen Prüfung war innerhalb 5 Jahren bei insgeLäßt sich die Gehörknöchelchenkette durch körpereigenes Material nicht zufriedenstellend wiederherstellen, so werden allogenes Gewebe oder alloplastische Werkstoffe wie Metalle, Kunststoffe und Keramiken verwendet [4]. Das hybride Knochenersatzmaterial Ionomerzement (Ionos, Seefeld bis 12/95; Xomed, Gilching ab 01/96) läßt sich nicht den genannten Werkstoffklassen zuordnen.…”

Section: Klinische Prüfungunclassified

Ionomerzementprothesen in der rekonstruktiven Mittelohrchirurgie

Helms

1997

HNO

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Animal experiments with microbiologic examinations and studies in cell cultures have shown that ionomer cement is a biocompatible and biostable bone replacement material in the head and neck region. Clinical and functional results of its use in the human middle ear have proven to be satisfactory during a maximal period of 2.5 years observation. The present trial was continued in order to determine the long-term behavior of ionomer cement (Ionos partial and total ossicles) after reconstruction of the ossicular chain. The ossicular chain was reconstructed in 343 cases and included various losses of one or more of the ossicles (i.e., incus, incus and malleus, incus and stapes superstructure, and malleus, incus and stapes superstructure). Follow-up extended over a maximum period of 5.5 years. Patients were examined under a surgical microscope and a pure-tone audiogram was performed at regular intervals. Clinical and audiological results were obtained 3 months postoperatively in all reconstructive procedures performed (partial and total ossicular replacement prostheses). These were mainly stable but revision surgery was necessary in 9% of the cases. In 5% the prosthesis was displaced and in 3% the prosthesis had partially migrated through the eardrum. Complete rejection of the implants was observed in the course of infections in 1% of the cases. Ionomer cement as a bone replacement material was found to have all required criteria for its use in the middle ear (biocompatibility, biostability, stable audiologic results and easy workability). These findings show that ionomer cement can be recommended in all cases of ossicular reconstruction.

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Implantate in der Mittelohrchirurgie

Cited by 26 publications

References 176 publications

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Zur Beeinflussung des Bakterienwachstums durch alloplastische Knochenersatzmaterialien

Ionomerzementprothesen in der rekonstruktiven Mittelohrchirurgie

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Implantate in der Mittelohrchirurgie

Cited by 26 publications

References 176 publications

Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Zur Beeinflussung des Bakterienwachstums durch alloplastische Knochenersatzmaterialien

Ionomerzementprothesen in der rekonstruktiven Mittelohrchirurgie

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Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study