Implantable technology for long-term delivery of nalmefene for treatment of alcoholism

Costantini, Lauren C.; Kleppner, Sofie R.; McDonough, Joseph M.; Azar, Marc R.; Patel, Raj

doi:10.1016/j.ijpharm.2004.05.034

Cited by 31 publications

(16 citation statements)

References 23 publications

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“…On account of its good biocompatibility, EVA has been utilized to prepare various local drug delivery systems in order to achieve sustained and controlled drug release. Studies showed that drug-loaded EVA rods provided stable drug levels for 6 months and presented no adverse effects (Costantini et al, 2004). EVA films were also used as matrix systems for the delivery of different drugs (Guo et al, 2007b;Tallury et al, 2007) and proteins (Amsden and Cheng, 1995).…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and properties of partially hydrolyzed ethylene vinyl acetate copolymer films for controlled drug release

Tang

Hou

Lei

et al. 2010

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization and properties of partially hydrolyzed ethylene vinyl acetate copolymer films for controlled drug release

Tang

Hou

Lei

et al. 2010

International Journal of Pharmaceutics

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“…Poly(ethylene-covinyl acetate) and poly(oxyethylene-b-oxypropylene-b-oxyethylene) are block copolymers which have numerous and recognised applications in the development of CDDSs mainly because of their biocompatibility, processability (e.g. extrusion) and proved long-term release properties [22][23][24][25][26].…”

mentioning

confidence: 99%

Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications

Natu

Gil

Sousa

2008

The Journal of Supercritical Fluids

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Please cite this article as: M.V. Natu, M.H. Gil, H.C. de Sousa, Supercritical Solvent Impregnation of Poly( -caprolactone/poly(oxyethylene-b-oxypropylene-boxyethylene) and Poly( -caprolactone/poly(ethylene-vinyl acetate) Blends for Controlled Release Applications, The Journal of Supercritical Fluids (2007Fluids ( ), doi:10.1016Fluids ( /j.supflu.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractPoly(ε-caprolactone) blends were successfully impregnated with timolol maleate, an antiglaucoma drug, using a Supercritical Solvent Impregnation (SSI) technique. Supercritical fluid impregnation efficiency results suggested that the best impregnating conditions were obtained when a cosolvent was used and when specific drug-polymer interactions occurred as a consequence of different chemical structures due to polymer blending. Pressure can be either a favourable factor, when there is enough drug affinity for the polymers, or an unfavourable factor when weaker bonding is involved. In order to determine the relative * ManuscriptPage 2 of 40 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 hydrophilicity/hydrophobicity of the blends, contact angle analysis was performed, while crystallinity determination was also useful to understand the obtained release profiles.Drug loading, heterogeneous/homogeneous dispersion of drug inside the matrix, hydrophilicity, crystallinity, all seem to influence the obtained drug release rates. The "in vitro" release results suggested that a sustained drug release rate can be obtained by changing the SSI operational conditions and by modulating the composition of blends, as a mean to control crystallinity, hydrophilicity and drug affinity for the polymer matrix. After a first day burst release, all samples showed a sustained release profile (1.2-4 µg/ml/day, corresponding to a mass of 3-10 µg/day) which is between the therapeutic and toxic levels of timolol maleate, during a period of 1 month. These drug-loaded polymeric matrices can be a feasible alternative treatment modality for the conventional repeated daily administration of eye drops.

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“…Intramuscular injection of naltrexone-loaded PLGA microspheres (Medisorb ® ) achieved stable, pharmacologically relevant plasma levels of naltrexone for at least 28 days [ 62 ] . Nonerodible rods that provide 6 months delivery of nalmefene (a pure opioid antagonist structurally similar to naltrexone) have been successfully developed to achieve prolonged therapeutic activity [ 65 ] .…”

Section: Drugs Used For Treatment Of Alcohol Dependencementioning

confidence: 99%

Drugs for Long Acting Injections and Implants

Shen

Burgess

2011

Long Acting Injections and Implants

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Long acting injections and implants have been developed for controlled drug delivery to improve therapeutic effects, decrease dosing frequency, and also avoid potential drug toxicity. Many pharmaceutical agents, such as biomacromolecules (e.g. peptides, proteins and gene therapeutics), drugs with poor bioavailability, and drugs for local delivery are good candidates for developing long acting injections and implants. However, not all drugs are suitable for these formulations (for example, drugs with high dose or narrow therapeutic index). IntroductionDrug formulations should deliver the API (active pharmaceutical agent) to the site of action at the correct therapeutic concentration for as long as the treatment is desired. The therapeutic and the physicochemical properties of a drug determine the preferred route of administration (oral or parenteral) as well as the most appropriate delivery systems.Due to convenience and patient acceptability, oral drug delivery is the most attractive and preferred route for administering medicines. However, some drugs cannot be tolerated via the oral route due to the acid environment and the variety of proteolytic enzymes (proteases) in the gastrointestinal tract (GIT). These conditions tend to degrade or metabolize drugs such as proteins and peptides, resulting in low bioavailability [ 1 ] . Moreover, patients who are unable to tolerate oral ingestion (e.g. patients with aspiration problems or GI disorders) require nonoral administration (e.g. parenteral administration) to receive medications and nutrition. Parenteral administration (e.g. intravenous, intramuscular, and subcutaneous) is also useful

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Implantable technology for long-term delivery of nalmefene for treatment of alcoholism

Cited by 31 publications

References 23 publications

Preparation, characterization and properties of partially hydrolyzed ethylene vinyl acetate copolymer films for controlled drug release

Preparation, characterization and properties of partially hydrolyzed ethylene vinyl acetate copolymer films for controlled drug release

Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications

Drugs for Long Acting Injections and Implants

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