Implantable slow release cyclosporin A (CYA) delivery system to thoracic lymph duct

Polymeric Systems for Controlled Drug Release

“…A large number of classes of drugs can benefit from temporal or distribution controlled release. These classes include chemotherapeutic drugs, , immunosuppressants, antiinflammatory agents, − antibiotics, opioid antagonists, steroids, hormones, anesthetics, and vaccines . Recently, the need to develop new controlled release strategies has been intensified by advances in the design of peptide drugs and emergence of gene therapy.…”

Controlled poly(l-lactide-co-trimethylene carbonate) delivery system of cyclosporine A and rapamycine – the effect of copolymer chain microstructure on drug release rate

“…Targeting to lymphatics has been suggested as the parameter to improve CyA formulations (Gref et al, 2001;Katayama et al, 1995). The possibility to obtain slow release of CyA after implant administration onto the surface of thoracic duct was reported (Katayama et al, 1995). Rapamycin possesses immunosuppressive properties and is used clinically to prevent acute renal allograft rejection.…”

“…Local immunosuppression may reduce the drug specific and general adverse consequences of systemic immunosuppression. Targeting to lymphatics has been suggested as the parameter to improve CyA formulations (Gref et al, 2001;Katayama et al, 1995). The possibility to obtain slow release of CyA after implant administration onto the surface of thoracic duct was reported (Katayama et al, 1995).…”

Polymers and Drug Delivery Systems

“…Many different kinds of drugs can benefit from distribution or time-controlled delivery, such as anti-inflammatory agents [3], antibiotics [4], chemotherapeutic drugs [5], immunosuppressants [6], anesthetics [7] and vaccines [8].…”