Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

Kim, S.; Yang, Hyung Kook; Eum, Jaehong; Ma, Yu-Seung; Lahiji, Shayan Fakhraei; Jung, Hyungil

doi:10.1016/j.biomaterials.2019.119733

Cited by 70 publications

(51 citation statements)

References 42 publications

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“…e Comparisons of the amount of permeated calcein between the patch and the implantation group after 24 h. Reprinted from Ref. [202] with permission from Elsevier system, patients with diabetes will not have access to a micropillar-based implantation system, and thus, the results from this study are not necessarily translatable to real-life use [202]. Currently, patients commonly use patches for transdermal drug delivery applications.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

“…17) [202]. Calcein was used as a control drug, and permeation of calcein was 147 and 206 µg for the patch group and implantation group, respectively [202]. Whilst the results are positive and indicate that powder insulin delivery was possible from this system, similarly to the near-infrared Reprinted from Ref.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

“…The patch group showed incomplete implantation of the MNs, whereas the implantation group showed perfect implantation of MNs; therefore, no calcein powder was left on the skin as was the case with the patch group (black arrows). e Comparisons of the amount of permeated calcein between the patch and the implantation group after 24 h. Reprinted from Ref [202]. with permission from Elsevier…”

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confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

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Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

mentioning

confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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“…Appropriate fabrication methods should be applied to gain sensitive drug-loaded MNs, because harsh processing conditions (e.g., heat and light irradiation) will affect the activity of sensitive drugs. Recently, Kim et al designed a self-administrative powder-carrying MN to directly implant insulin powder inside skin [170]. A dissolving MN array with empty cavities in the center was prepared by a mold-casting method.…”

Section: Discussionmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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“…and are currently used for biosensors, fluid sampler and micro-analysis (Chen et al, 2017;Yu et al, 2017;Zhao et al, 2017;Yin et al, 2018;Ali et al, 2020). Powder carrying microneedles are more appreciated compared with dissolving microneedles because of its validity to various powder therapeutics (Kim et al, 2020).…”

Section: Microneedlesmentioning

confidence: 99%

Approaches and Recent Advances in Protein and Peptide Drug Delivery System

Naz¹,

Saeed²,

Irfan³

2020

Pakistan J. Med. Health Sci.

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Peptide and protein drug are commercially available as therapeutics and are prepared by various biotechnology processes.As they lack drug stability during their delivery, so protein structures are modified to maintain pharmaceutical properties of proteins. Various approaches for delivery of protein and peptide drugs are used for proper formulation of drugs. In addition, various advancements in protein and peptide drug delivery have try to overcome the issues during delivery of these therapeutics like increased stability, low toxicity level and increased resistance to proteolytic inactivation, bioavailability, efficiency and improve circulation period. There is a need to develop multifunctional drugdelivery systems and advance technologies that allow production of high quality products at affordable cost. The study was conducted to check various approaches and recent advances in protein/peptide drug delivery system to improve patient compliance when compared with conventionalmethods for drug delivery.

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Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

Cited by 70 publications

References 42 publications

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedles for Therapy and Diagnosis: A Survey

Approaches and Recent Advances in Protein and Peptide Drug Delivery System

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