Implantable polymeric microneedles with phototriggerable properties as a patient-controlled transdermal analgesia system

Chen, Mei-Chin; Chan, Hao An; Ling, Ming Hung; Su, Liang Cheng

doi:10.1039/c6tb02718k

Cited by 40 publications

(29 citation statements)

References 40 publications

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“…A 3D image of nine implantation sites created by FR-loaded IPMNs in the porcine ear skin is displayed in Figure 4b, which visually indicates that PLGA arrowheads were completely implanted into the skin as drug depots. These results made it possible to dramatically improve drug utilization [44][45][46]. Figure 4b, which visually indicates that PLGA arrowheads were completely implanted into the skin as drug depots.…”

Section: Separability and Insertion Depthmentioning

confidence: 90%

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Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles

et al. 2020

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Hydrophobic drugs wrapped in poly (lactic-co-glycolic acid) (PLGA)-based microneedles (MNs) require a long time to release completely. To obtain the desired duration, it is still necessary to modulate the release of hydrophobic drugs from MNs, while the PLGA composition is unchangeable. In this work, implantable PLGA microneedles (IPMNs) composed of PLGA arrowheads encapsulating levonorgestrel (LNG) and a water-soluble supporting array were designed. We explored trehalose used as a porogen on the release of hydrophobic LNG from PLGA-based MNs. Varying the trehalose content in PLGA arrowheads could induce different rates of drug release. The highest cumulative release of LNG was 76.2 ± 3.9% for IPMNs with 33.3% trehalose during 21 days in vitro, while the cumulative release of LNG was 60.4 ± 3.5% for IPMNs without trehalose. Pharmacokinetic results in rats showed that plasma levels of LNG were sustained for 13 days for IPMNs with 33.3% trehalose and 16 days for IPMNs without trehalose. Furthermore, the PLGA arrowheads with trehalose degraded more rapidly than those without trehalose over 21 days in rats. Consequently, using trehalose as a porogen was a feasible approach to modulate the release of a hydrophobic drug from PLGA-based MNs.

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Section: Separability and Insertion Depthmentioning

confidence: 90%

“…Figure 4b, which visually indicates that PLGA arrowheads were completely implanted into the skin as drug depots. These results made it possible to dramatically improve drug utilization [44][45][46].…”

Section: Separability and Insertion Depthmentioning

confidence: 99%

Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles

et al. 2020

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“…Beyond the light‐triggered delivery of hypoglycemic drugs, in recent times there has been an increasing effort in developing microneedle‐based glucose‐responsive insulin delivery systems . These bioresponsive microneedles will potentially mimic the physiological response to changes in blood glucose levels and release insulin on‐demand.…”

Section: Microneedle Patches For Transdermal Deliverymentioning

confidence: 99%

“…In the presence of high glucose levels, the local hypoxic microenvironment caused by the oxygen consumption in the catalytic reaction of glucose to gluconic acid promoted the bioreduction of 2‐nitroimidazole and the dissociation of the HA‐derivate vesicles, with the subsequent release of insulin. The drop in the microenvironment pH caused by the reaction of glucose to gluconic acid has also been exploited to trigger the release of insulin 87b. Likewise, H 2 O 2 , a byproduct of the catalytic reaction, may be employed to trigger the release of insulin.…”

Section: Microneedle Patches For Transdermal Deliverymentioning

confidence: 99%

Micro‐ and Nanosystems for Advanced Transdermal Delivery

Alba

Tabassum

et al. 2019

Advanced Therapeutics

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The skin is the largest and most accessible organ in the human body and, as such, it appears as the most convenient portal for drug delivery. However, the skin is also a formidable barrier which, while protecting us from physical, chemical, and immunological agents, requires appropriate technology for effective delivery. Today, the most effective administration method for large, lipophobic, and polar molecules continues to be hypodermic injection, which is associated with pain, needle phobia, and stick injury. As an alternative, a range of advanced strategies to overcome the skin barrier have been established over the last few decades including chemical enhancement, sonophoresis, iontophoresis, electroporation, thermal ablation, and mechanical approaches. Encouraged by the advances in nanotechnology, micro-and nanosystems have emerged as powerful tools to overcome the skin barrier, enabling significant advances on the existing methods. In particular, microneedle-and nanoparticle-assisted transdermal delivery has gained significant traction and will most likely have a strong impact in the field. In this review, the most recent progress in the field of transdermal delivery based on microneedle and nanoparticle delivery systems is discussed and examples of key therapeutic application are provided. Finally, a critical summary is presented alongside a vision for future research directions.

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“…The IC50 of IDAU-MNPs was 0.02 ± 0.007 mg/mL and was much lower than that of free DAU or IDAU, but the presence of low activity against DLKP cells confirmed that a small quantity of IDAU on the surface of MNPs stretched in aqueous medium and interacted with tumor cells. Another reason that IDAU-MNPs had anticancer activity in vitro was a pumping mechanism that enabled diffusion of the drug out of avidin on the surface of nanoparticles [46][47][48].…”

mentioning

confidence: 99%

Preparation and Evaluation of Smart Nanocarrier Systems for Drug Delivery Using Magnetic Nanoparticle and Avidin-Iminobiotin System

Sun

Yang

et al. 2018

Journal of Nanomaterials

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Therapeutic efficacy and the regulation of drug release can be improved by using selective targeting drug delivery systems. In this paper, we have demonstrated avidin-immobilized magnetic nanoparticles (AMNPs) as a novel targeted drug delivery system to deliver iminobiotinylated daunomycin (IDAU). TEM, XRD, VSM, and FTIR were employed for the physicochemical characterization of the drug-loaded MNPs. The binding of IDAU had little effect on sizes of AMNPs (~35 nm), but the stability and dispersibility of the nanoparticles were improved. The study also found that the loading capacity and efficiency of nanoparticles were mainly dependent on affinity interaction between IDAU and AMNPs. The optimal loading capacity and efficiency of MNPs for IDAU were 0.408 ± 0.012 mg/g and 94.18 ± 2.64% according to the reversed-phase high-performance liquid chromatography (RP-HPLC) data, respectively. Under the conditions of pH 6.8 and 1 mmol/L of biotin, the drug-loaded MNPs released rapidly at beginning and then maintained at a certain controllable release level. The effect of IDAU on DLKP proliferation was tested, and the results showed that IC50 was (1.60 ± 0.05) × 10−3 mg/mL. Our findings indicated that AMNPs hold tremendous potential as an effective drug delivery system.

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Implantable polymeric microneedles with phototriggerable properties as a patient-controlled transdermal analgesia system

Abstract: Phototriggerable microneedles (MNs) can be quickly implanted into the skin as a depot for the on-demand delivery of pain medicines.

Cited by 40 publications

References 40 publications

Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles

Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles

Micro‐ and Nanosystems for Advanced Transdermal Delivery

Preparation and Evaluation of Smart Nanocarrier Systems for Drug Delivery Using Magnetic Nanoparticle and Avidin-Iminobiotin System

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