Implantable Pharmacological Defibrillator (AIPhD): Preliminary Investigations in Animals

Cammilli, L; Mugelli, Alessandro; Grassi, G; Alcidi, L; Melissano, Germano; Menegazzo, Giampaolo; Silvestri, V.

doi:10.1111/j.1540-8159.1991.tb05126.x

Cited by 11 publications

(1 citation statement)

References 9 publications

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“…An automatic implantable pharmacologic defibrillator currently is being tested by Cammilli et al 20 This device combines electrical therapy with pharmacologic treatment. It represents an alternative course in the treatment of refractory ventricular tachycardias, providing it can be refined and tested to the point that it finds clinical application.…”

Section: Cardiac Pacemakersmentioning

confidence: 99%

We Have Come a Long Way with Device Therapy: Historical Perspectives on Antiarrhythmic Electrotherapy

Lüderitz

2002

Cardiovasc electrophysiol

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Historical Perspectives on Antiarrhythmic Electrotherapy. The history of device therapies is long and fascinating. In the beginning, there is not simply the anatomy and physiology of the heart, but also analysis of the pulse, which indicates the activity of the heart. The analysis of the (peripheral) pulse as a mechanical expression of heart activity goes back several millennia. In China, in 280 BC, Wang Shu He wrote 10 books about the pulse. The Greeks called the pulse “sphygmos”; thus, sphygmology deals with a theory of this natural occurrence. In Roman times, Galen interpreted the various types of pulse according to the widespread presumption of the time that each organ in every disease has its own form of pulse. The growing clinical importance of electrical cardiac stimulation was recognized and renewed as Zoll in 1952 described a successful resuscitation in cardiac standstill by external stimulation. Meanwhile, millions of patients with cardiac arrhythmias worldwide have been treated with pacemakers in the last 40 years. The concept of a fully automatic implantable cardioverter defibrillator system for recognition and treatment of ventricular tachyarrhythmias was first suggested in 1970. The first implantation of the device in a human being was performed in February 1980. Further developments involved atrial and atrioventricular defibrillators, radiofrequency ablation, laser therapy, and advanced antiarrhythmic surgery. Since 1990, there has been a growing interest in using cardiac pacing as additional treatment in severe cardiac failure. Recent reports have suggested that intervention with left ventricular or biventricular pacing may be helpful for a subgroup of patients with congestive heart failure. Despite encouraging (preliminary) acute and short‐term results, pacing strategies for heart failure still are limited and currently regarded as investigational. Advances in the field of therapeutic application of pharmacologic and electrical tools as well as alternative methods will continue as rapidly as before and provide us further significant aid in taking care of patients.

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Section: Cardiac Pacemakersmentioning

confidence: 99%