Implantable Medical Devices and Tissue Engineering: An Overview of Manufacturing Processes and the Use of Polymeric Matrices for Manufacturing and Coating their Surfaces

Dutra, Gabriel Victor Simões; Neto, Weslany Silvério; Dutra, João Paulo Simões; Machado, Fabricio

doi:10.2174/0929867325666180914110119

Cited by 14 publications

(9 citation statements)

References 125 publications

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“…In general, inorganic and perovskite/wurtzite piezoelectric materials ( e.g. , AlN, LiNbO 3 , ZnO) display biocompatibility characteristics or can be turned into biocompatible materials through specific processing, encapsulation, or coating . On the other hand, organic polymers exhibit biocompatibility features.…”

Section: Physics Of Piezoelectric Nanomaterials and Ultrasound Wavesmentioning

confidence: 99%

Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption

et al. 2021

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Electrical stimulation has shown great promise in biomedical applications, such as regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical end effectors such as electrodes requires connectors and batteries, which dramatically hamper the translation of electrical stimulation technologies in several scenarios. Piezoelectric nanomaterials can overcome the limitations of current electrical stimulation procedures as they can be wirelessly activated by external energy sources such as ultrasound. Wireless electrical stimulation mediated by piezoelectric nanoarchitectures constitutes an innovative paradigm enabling the induction of electrical cues within the body in a localized, wireless, and minimally invasive fashion. In this review, we highlight the fundamental mechanisms of acoustically mediated piezoelectric stimulation and its applications in the biomedical area. Yet, the adoption of this technology in a clinical practice is in its infancy, as several open issues, such as piezoelectric properties measurement, control of the ultrasound dose in vitro , modeling and measurement of the piezo effects, knowledge on the triggered bioeffects, therapy targeting, biocompatibility studies, and control of the ultrasound dose delivered in vivo , must be addressed. This article explores the current open challenges in piezoelectric stimulation and proposes strategies that may guide future research efforts in this field toward the translation of this technology to the clinical scene.

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Section: Physics Of Piezoelectric Nanomaterials and Ultrasound Wavesmentioning

confidence: 99%

Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption

et al. 2021

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“…According to the American Society for Testing and Materials (ASTM) and International Standard Rule ISO-17296-2:2017, all current 3D-printing strategies are classified into seven procedures: (i) fused deposition model (FDM), also known as material extrusion, (ii) powder bed fusion, (iii) vat photopolymerization, (iv) material jetting, (v) binder jetting, (vi) sheet lamination, and (vii) directed energy deposition [71,72]. Technical specifications, potential biomedical applications and limitations have been comprehensively reviewed by others [69,[73][74][75][76].…”

Section: Overview Of 3d-printing Technology For Biomedical Applicationsmentioning

confidence: 99%

New Insights into the Application of 3D-Printing Technology in Hernia Repair

et al. 2021

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Abdominal hernia repair using prosthetic materials is among the surgical interventions most widely performed worldwide. These materials, or meshes, are implanted to close the hernial defect, reinforcing the abdominal muscles and reestablishing mechanical functionality of the wall. Meshes for hernia repair are made of synthetic or biological materials exhibiting multiple shapes and configurations. Despite the myriad of devices currently marketed, the search for the ideal mesh continues as, thus far, no device offers optimal tissue repair and restored mechanical performance while minimizing postoperative complications. Additive manufacturing, or 3D-printing, has great potential for biomedical applications. Over the years, different biomaterials with advanced features have been successfully manufactured via 3D-printing for the repair of hard and soft tissues. This technological improvement is of high clinical relevance and paves the way to produce next-generation devices tailored to suit each individual patient. This review focuses on the state of the art and applications of 3D-printing technology for the manufacture of synthetic meshes. We highlight the latest approaches aimed at developing improved bioactive materials (e.g., optimizing antibacterial performance, drug release, or device opacity for contrast imaging). Challenges, limitations, and future perspectives are discussed, offering a comprehensive scenario for the applicability of 3D-printing in hernia repair.

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“…The underlying pathological mechanisms of these complications are surface-induced reactions of plasma proteins, platelets and leukocytes. Uncoated medical devices often adsorb blood plasma proteins, such as fibrinogen, on their surfaces, thereby inducing an inflammatory process, platelet adhesion and activation of the coagulation [ 2 , 3 , 4 , 5 , 6 ]. Adsorbed proteins further mediate platelet aggregation and, in combination with fibrin, can form a platelet-fibrin thrombus [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Recombinant Fusion Construct between Human Serum Albumin and NTPDase CD39 Allows Anti-Inflammatory and Anti-Thrombotic Coating of Medical Devices

et al. 2021

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Medical devices directly exposed to blood are commonly used to treat cardiovascular diseases. However, these devices are associated with inflammatory reactions leading to delayed healing, rejection of foreign material or device-associated thrombus formation. We developed a novel recombinant fusion protein as a new biocompatible coating strategy for medical devices with direct blood contact. We genetically fused human serum albumin (HSA) with ectonucleoside triphosphate diphosphohydrolase-1 (CD39), a promising anti-thrombotic and anti-inflammatory drug candidate. The HSA–CD39 fusion protein is highly functional in degrading ATP and ADP, major pro-inflammatory reagents and platelet agonists. Their enzymatic properties result in the generation of AMP, which is further degraded by CD73 to adenosine, an anti-inflammatory and anti-platelet reagent. HSA–CD39 is functional after lyophilisation, coating and storage of coated materials for up to 8 weeks. HSA–CD39 coating shows promising and stable functionality even after sterilisation and does not hinder endothelialisation of primary human endothelial cells. It shows a high level of haemocompatibility and diminished blood cell adhesion when coated on nitinol stents or polyvinylchloride tubes. In conclusion, we developed a new recombinant fusion protein combining HSA and CD39, and demonstrated that it has potential to reduce thrombotic and inflammatory complications often associated with medical devices directly exposed to blood.

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Implantable Medical Devices and Tissue Engineering: An Overview of Manufacturing Processes and the Use of Polymeric Matrices for Manufacturing and Coating their Surfaces

Cited by 14 publications

References 125 publications

Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption

Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption

New Insights into the Application of 3D-Printing Technology in Hernia Repair

A Recombinant Fusion Construct between Human Serum Albumin and NTPDase CD39 Allows Anti-Inflammatory and Anti-Thrombotic Coating of Medical Devices

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