Implantable Cisplatin Synthesis Microdevice for Regional Chemotherapy

Abstract

Cisplatin, the first platinum chemotherapy agent to obtain Food and Drug Administration (FDA) approval in 1978, is widely used for a number of cancers. However, the painful side effects stemming from systemic delivery are the inevitable limitation of cisplatin. A possible solution is regional chemotherapy using various drug delivery systems, which reduces the systemic toxicity and increases drug accumulation in the tumor. In this paper, a rice-grain sized, ultrasonically powered, and implantable microdevice that can synthesize cisplatin in situ is presented. The microdevice produces 0.7 mg of cisplatin within 1 h under ultrasonic irradiation (400 mW cm −2). The effect of the microdevice-synthesized cisplatin is evaluated using in vitro murine breast cancer cells and ex vivo liver tissue. The results suggest that cytotoxic activities of the microdevice-mediated cisplatin delivery are significantly higher in both in vitro and ex vivo experiments. Overall, the proposed cisplatin synthesis microdevice represents a strong alternative treatment option for regional chemotherapy

Hyaluronic Acid-Modified Gold-Polydopamine Complex Nanomedicine for Tumor-Targeting Drug Delivery and Chemo-Photothermal-Therapy Synergistic Therapy

“…Despite the rapid development of medical technology in the several decades, cancer is still an important factor leading to human death worldwide . Conventional chemotherapy, as the most commonly used cancer therapeutic approach, does not achieve a satisfactory and sustainable therapeutic effect, due to the dose limitation, the damage to healthy tissues, and the drug resistance . Therefore, there is an urgent need for a novel method that can exert a favorable therapeutic effect at low doses.…”

Implantable smart hyperthermia nanofibers for cancer therapy: Challenges and opportunities

“…F I G U R E 4 Schematic illustration of microdevice-synthesized cisplatin on (A) ovarian and (B) liver cancer cells (Adapted from Ref [Campbell et al, 2021]. with permission).VALIZADEH ET AL.…”

Omni-Directional Ultrasonic Powering via Platonic Solid Receiver for mm-Scale Implantable Devices

“…Ultrasonic powering was introduced as a promising resolution of the above-mentioned shortcomings, particularly for millimeter-scale implantable devices. − Using a piezoelectric receiver, ultrasonic waves propagating through the body are converted into electrical energy. The resulting electrical energy then powers various vital sensing, stimulation, and more. ,− Compared to inductive powering, ultrasonic powering presents numerous advantages, including a long operation distance, high efficiency, and a small receiver (millimeter-scale).…”

“…Owing to such geometric symmetry and radial poling, the Platonic solid ultrasonic receivers increase the probability of aligning the incident waves and poling vector at any given angle, resulting in improved power transfer efficiency. Moreover, the Platonic solids receivers could be engineered for the seamless packaging of various vital payloads (e.g., electrical stimulation, electrochemical reaction, or an LC (inductor-capacitor) resonator for wireless sensing). For example, we demonstrated an implantable light source using the Platonic solid receiver by pairing it with light-emitting diodes (LEDs) .…”