Implantable Biosensor Interface Platform for Monitoring of Atherosclerosis

Abstract

The drug-eluting stents (DESs) have been considered as an effective technique to reduce the severity of atherosclerotic stenosis. Recent technological advances have opened the door for developing new and innovative smart cardiovascular stents by integrating various electronics components and sensors to improve health monitoring and diagnosis. Rupture of atherosclerotic plaque represents the major cause of cardiovascular disease (CVD) such as heart attacks due to blockages of the arterial lumen. Pentraxin-3 (PTX3) is a novel localized inflammatory biomarker associated with the development of atherosclerosis and plaque vulnerability. In this paper, we propose a biosensor interface platform for monitoring the plaque vulnerability via detection and prediction of the inflammatory biomarker (PTX3). We propose mathematical and stochastic models using molecular communication paradigm for detection of Pentraxin-3 (PTX3) molecules in the atherosclerotic arterial wall using biosensor attached to a vascular stent inside the artery. The proposed platform and models can help in the localized sensing of the atherosclerotic biomarkers for monitoring of the plaque progression and for early warning of certain disorders such as heart attack.

On the Use of Impedance Detuning for Gastrointestinal Segment Tracking of Ingestible Capsules

“…application fields of such devices include metabolite monitoring [10], hypertension monitoring [11], blood flow sensing [12], [13], blood glucose monitoring [14]- [16], wireless endoscopy [17]- [19], gastrointestinal (GI) pH, temperature [20], and gas sensing [21].…”