Implant of porous titanium nickelide impregnated with autologous blood monocytes for the formation of orbital stump in the experiment

Gorbunova, Ye. A.; Krivosheina, O. I.; Zapuskalov, I. V.

doi:10.20538/1682-0363-2011-4-12-14

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Otherwise, the physiological load on the bone fragments is shielded by the implant, which causes degradation of newly formed bone tissue in the bio-interface region and its replacement with connective tissue. Wrought Nitinol and porous TiNi-based alloys have been successfully deployed in the medical industry due to their rheological similarity to biological tissues, namely, reversible viscoelastic deformation under cyclic alternating loads [7,8].…”

Section: Introductionmentioning

confidence: 99%

Retracted: Study on tensile, bending, fatigue, and in vivo behavior of porous SHS–TiNi alloy used as a bone substitute

Yasenchuk¹,

Марченко²,

Baigonakova³

et al. 2021

Biomed. Mater.

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Intermetallic porous SHS–TiNi alloys exhibit tangled and specific stress–strain characteristics. This article aims to evaluate the findings emanating from experiments using standard and proprietary instruments. Fatigue testing under repeated complex loading was used to measure the total number of load cycles before failure of the SHS–TiNi samples occurred. Of the tested samples, seventy percent passed through 106 cycles without failure due to the reversible martensite transformation in the TiNi phase, one of the prevailing constituents of a multiphase matrix. The fractured surfaces were analyzed using scanning electron microscopy and confocal laser scanning instruments. Microscopy studies showed that the entire surface of the sample is concealed by miscellaneous strata that result from the SHS processand effectively protect the porous alloy in a corrosive environment. Numerous non-metallic inclusions, which are also attributed to the SHS reaction, do not have a significant impact on the deformation behavior and fatigue performance. In this context, the successful in vivo functioning of porous grafts assessed in a canine rib-plasty model allows the bone substitute to be congruentially deformed in the body without rejection or degradation; it thus has a long operational life, often greater than 17 ×106 (22 × 60 × 24 × 540) cycles. It acknowledges the potential benefits of SHS–TiNi as a superior osteoplastic material and its high resistance to corrosion fatigue.

show abstract

Section: Introductionmentioning

confidence: 99%

Retracted: Study on tensile, bending, fatigue, and in vivo behavior of porous SHS–TiNi alloy used as a bone substitute

Yasenchuk¹,

Марченко²,

Baigonakova³

et al. 2021

Biomed. Mater.

View full text Add to dashboard Cite

show abstract

“…The disadvantages of natural and some synthetic orbital implants (polymeric, ceramic, carbon based, etc.) are their exposure, rejection and deformation [13,[16][17][18][19][20][21][22][23][24][25]. Metallic implants were found to be well-applicable and very promising for use in ophthalmology in general, and for the formation of the full-fledged musculoskeletal stump of the eyeball after its removal, in particular [25].…”

Section: Introductionmentioning

confidence: 99%

Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants

Anikeev,

Hodorenko,

Kaftaranova

et al. 2024

Preprint

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The study focuses on a novel porous TiNi-based material for ophthalmic orbital implants which was produced by self-propagating high-temperature synthesis (SHS) and, after proper surface modification, possesses a specific microstructure of its surface pores, which makes it attractive for biomedical use in implants. After preparation via SHS, the obtained porous TiNi material was etched in acidic environment, to get rid of its surface Ti2Ni secondary-phase particles. This was found to improve the material’s surface morphology, adding micro-roughness to its macro-rough pores. As a result, cell growth tests conducted on the material demonstrated improved cell adhesion and growth kinetics on such a porous material with improved roughness. Finally, the material was tested in vivo as an ophthalmic orbital implant, demonstrating good biocompatibility, good degree of biointegration with surrounding eyeball tissues, and no signs of rejection after as long as 180 days. Thus, the novel porous TiNi-based material shows promise for its use in ophthalmic implantology, for instanse for manufacturing musculoskeletal stumps of the eyeball after evisceration, as it is biocompatible, has a high tissue-implant integration potential and demonstrates reduced risks of exposure and rejection of the implant.

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“…2 etc.) are their exposure, rejection and deformation [13,[16][17][18][19][20][21][22][23][24][25]. Metallic implants were found to be well-applicable and very promising for use in ophthalmology in general, and for the formation of the full-fledged musculoskeletal stump of the eyeball after its removal, in particular [25].…”

Section: Introductionmentioning

confidence: 99%

Porous SHS material based on TiNi with a microporous surface structure of its pore walls for creating an ophthalmic orbital implants

Anikeev,

Hodorenko,

Kaftaranova

et al. 2023

Preprint

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This work deals with a novel porous TiNi-based material for ophthalmic orbital implants that was produced by high-temperature synthesis (SHS) and possesses a specific microstructure of its surface pores, which makes it attractive for biomedical use in implants. After preparation via SHS, the obtained porous TiNi material was etched in acidic environment, to get rid of its surface Ti2Ni secondary-phase particles. This was found to improve the material’s surface morphology, adding micro-roughness to its macro-rough pores. As a result, cell growth tests conducted on the material demonstrated improved cell adhesion and growth kinetics on such a porous material with improved roughness. Finally, the material was tested in vivo as an ophthalmic orbital implant, demonstrating good biocompatibility, good degree of biointegration with surrounding eyeball tissues, and no signs of rejection after as long as 180 days. Thus, the novel porous TiNi-based material shows promise for its use in ophthalmic implantology, for instanse for manufacturing musculoskeletal stumps of the eyeball after evisceration, as it is biocompatible, has a high tissue-implant integration potential and demonstrates reduced risks of exposure and rejection of the implant.

show abstract

Implant of porous titanium nickelide impregnated with autologous blood monocytes for the formation of orbital stump in the experiment

Cited by 5 publications

References 2 publications

Retracted: Study on tensile, bending, fatigue, and in vivo behavior of porous SHS–TiNi alloy used as a bone substitute

Retracted: Study on tensile, bending, fatigue, and in vivo behavior of porous SHS–TiNi alloy used as a bone substitute

Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants

Porous SHS material based on TiNi with a microporous surface structure of its pore walls for creating an ophthalmic orbital implants

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