Imperatorin ameliorates kidney injury in diabetic mice by regulating the TGF-β/Smad2/3 signaling axis, epithelial-to-mesenchymal transition, and renal inflammation

Unleashing the pathological role of epithelial-to-mesenchymal transition in diabetic nephropathy: The intricate connection with multifaceted mechanism

“…Targeting EMT-related pathways and renal fibrosis factors with TGF-β inhibitors, anti-inflammatory medications, and antioxidants might have the potential to prevent kidney damage and slow the progression of diabetic nephropathy. This contention is supported by the fact that imperatorin, a naturally occurring furanocoumarin derivative with proven antioxidant and anti-inflammatory potential, has been reported to ameliorate kidney injury in diabetic mice by regulating the TGF-β/Smad2/3 signaling axis, renal inflammation and EMT, highlighting that imperatorin might be a potential candidate for the management of diabetic nephropathy[ 12 ]. Likewise, Schisandrin B, derived from Schisandra chinensis and known for its antioxidant and anti-inflammatory properties, has been attributed to reduced renal tubular cells’ EMT and mitochondrial dysfunction in db/db mice.…”