Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry

Abstract

Following the paradigm shift in the pharmaceutical industry from batch to continuous production, additional instrumentation and revision of control strategies to optimize material flow throughout the downstream processes are required. Tableting manufacturing is one of the most productive in terms of turnover and investment into new sensor technologies is an important decision-making step. This paper proposes a continuous solution to detect changes in material properties, and a control algorithm to aid in minimizing risk at the end-product line. Some of the sub-processes involved in tableting manufacturing perform changes in powder and liquid mixtures, granulation, density, therefore changing flow conditions of the raw material. Using impedance spectroscopy in a continuous sensing and monitoring context, it is possible to perform online identification of generalized (fractional) order parametric models where the coefficients are correlated to changes in material properties. The model parameters are then included in a self-tuning control gain used in ratio control as part of the local process control loop. The solution proposed here is easy to implement and poses a significant added value to the current state of art in pharmaceutical manufacturing technologies.

Impedance Spectroscopy and Its Application in Measurement and Sensor Technology

“…Tableting manufacturing has high requirements concerning changes in flow conditions of raw materials, which may lead to a lack of reproducibility. In [4], M. Ghita et al show how, with impedance spectroscopy supported by an online identification of generalized order parametric models, changes in material properties can be tracked by correlation of the model parameters. The proposed solution is easy to implement and provides significant added value to the pharmaceutical industry.…”