Impedance planimetric characterization of the esophagus in patients with severe systemic sclerosis

Villadsen, Gerda Elisabeth; Storkholm, Jan Henrik; Hendel, L.; Gregersen, Hans

doi:10.1016/0016-5085(95)27134-1

Cited by 17 publications

(38 citation statements)

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“…The interested reader is referred to those and other publications for methodological and analytical considerations and interpretation of the in vivo muscle function curves [10,13,15,[18][19][20][21][22][23][24][25]. Corresponding analysis on length-tension relations in muscle strips in vitro has been described in other papers [26,27].…”

Section: Discussionmentioning

confidence: 99%

Deterioration of Muscle Function in the Human Esophagus with Age

2008

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Most studies on the effect of aging on esophageal motor function have shown that peristaltic function deteriorates with age. Esophageal motor function is traditionally studied by means of manometry and radiography. Distension of the esophagus with evaluation of active and passive mechanical parameters have become available during recent years. In this study, we did a manometric swallow analysis and used the distension method to study esophageal properties and function during aging. An impedance planimetric probe with a bag for distension was placed in the distal esophagus of 25 healthy volunteers with a median age of 35 (range 23-86) years. Distensions were done at an infusion rate of 25 ml min(-1) with and without relaxation of neuromuscular activity with butylscopolamine. The infusion was reversed when moderate pain was experienced by the subjects. Swallow-induced contraction amplitudes decreased as function of age for persons older than 40 years (P < 0.05). The total and passive tension showed an exponential increase as function of the change in radius, whereas the active tension increased until it reached a local maximum point. The maximum active tension deteriorated as a function of age after the age of 40 years (P < 0.05). Furthermore, esophagus became stiffer with age. In conclusion, age-related changes of increased stiffness and reduced primary and secondary peristalsis were found in the human esophagus with a deterioration of esophageal function after the age of 40 years. Such changes may contribute to the high prevalence of reflux disease in elderly.

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Section: Discussionmentioning

confidence: 99%

Deterioration of Muscle Function in the Human Esophagus with Age

2008

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“…A four-electrode impedance-measurement system located inside a bag on a 0.85 m long 15-French probe (William Cook, Europe, Bjaeverskov, Denmark) was used for measurement of luminal CSA in the esophagus [9,10]. The bag was 4 cm long and made of 50 lm thick non-conducting polyurethane.…”

Section: Experimental Probe Designmentioning

confidence: 99%

“…If the sphincter pressure could not be measured (in four patients), the bag was placed approximately 7 cm proximal to the pressure inversion point. Distension was achieved by raising the pressure in the bag in steps from 0.5 to 1.0, 1.5, 2.0 3.0, 4.0, and 5.0 kPa by altering the height of the level container above the zero pressure level [10]. A maximum value of 5.0 kPa was chosen, because pilot studies on healthy volunteers showed the threshold for nasopharyngeal and retrosternal discomfort was reached at this pressure.…”

Section: Study Protocolmentioning

confidence: 99%

“…Thus, measurements are obtained at one specific locus. Furthermore, CSA is more closely associated with the diametrical changes in the esophageal lumen than volume is [9][10][11]. Previous mechanical studies of SS patients using impedance planimetry have shown esophageal and duodenal dilatation, wall stiffening, and reduced muscle contractility [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 95%

“…The contraction frequency and the amplitude of pressure recordings are commonly used to characterize GI motility [9,10,14]. Only sparse data have been obtained from GI studies on single contraction cycle analysis.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Characteristics of Distension-Evoked Peristaltic Contractions in the Esophagus of Systemic Sclerosis Patients

2011

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Esophageal tissue engineering: An in‐depth review on scaffold design

Tan

Chua

Leong

et al. 2011

Biotech & Bioengineering

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Treatment of esophageal cancer often requires surgical procedures that involve removal. The current approaches to restore esophageal continuity however, are known to have limitations which may not result in full functional recovery. In theory, using a tissue engineered esophagus developed from the patient's own cells to replace the removed esophageal segment can be the ideal method of reconstruction. One of the key elements involved in the tissue engineering process is the scaffold which acts as a template for organization of cells and tissue development. While a number of scaffolds range from traditional non-biodegradable tubing to bioactive decellularized matrix have been proposed to engineer the esophagus in the past decade, results are still not yet favorable with many challenges relating to tissue quality need to be met improvements. The success of new esophageal tissue formation will ultimately depend on the success of the scaffold being able to meet the essential requirements specific to the esophageal tissue. Here, the design of the scaffold and its fabrication approaches are reviewed. In this paper, we review the current state of development in bioengineering the esophagus with particular emphasis on scaffold design.

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Impedance planimetric characterization of the esophagus in patients with severe systemic sclerosis

Cited by 17 publications

References 0 publications

Deterioration of Muscle Function in the Human Esophagus with Age

Deterioration of Muscle Function in the Human Esophagus with Age

Mechanical Characteristics of Distension-Evoked Peristaltic Contractions in the Esophagus of Systemic Sclerosis Patients

Esophageal tissue engineering: An in‐depth review on scaffold design

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