Impedance Oscillometry: Emerging Role in the Management of Chronic Respiratory Disease

Abstract

In a population of symptomatic adults with suspected COPD, impedance oscillometry resistance measurements correlate with FEV and lung resistance increases with the severity of airflow limitation. In patients with asthma, IOS is a sensitive measure of airway hyperresponsiveness and bronchodilator response. Impedance oscillometry is evolving as an alternative measure to assess lung function pediatric and adult populations.

Small airway dysfunction on impulse oscillometry and pathological signs on lung ultrasound are frequent in post-COVID-19 patients with persistent respiratory symptoms

“…Importantly, IOS has been shown to be a sensitive method for the early diagnosis of PAD in various conditions and can detect PAD even before clinical manifestations or spirometric abnormalities appear [ 14 , 36 ]. In line with these findings, we observed an R4-R20 value >20%—a marker of nonuniformity of airflow distribution and PAD [ 20 , 37 ]—in almost two-thirds of the cases at M1 and in more than half of the cases at M2, with a pronounced decrease in this parameter in the total sample when the two time points were compared (p < 0.0001). In COVID-19, viral particles were found by electron microscopy in the distal airway mucosal epithelia, potentially resulting in bronchiolitis, a reduction in airway caliber, and even bronchiolar hyperresponsiveness [ 38 ].…”

Lung function and self-rated symptoms in healthy volunteers after exposure to hydrotreated vegetable oil (HVO) exhaust with and without particles

“…However, studies with larger numbers of subjects need to be carried out in order to draw any conclusions. It should also be noted that this group did not show any indications of anomalies in the spirometry similar to observations previously reported [65][66][67] and for future controlled exposure studies, the oscillometry measurement may increase the possibility to investigate small differences in lung function. In addition, oscillometry may potentially be valuable in the assessment of lung function effects related to occupational exposures for early detection and disease prevention.…”

“…This highlights the need for more sensitive analysis methods due to the ethical considerations limiting the exposure concentration and length. In previous studies, oscillometry measurements found early manifestations of lung disease before these were measurable with spirometry [65,66]. One study using oscillometry measurements found increased resistance and reactance correlated to acute diesel exhaust (NO 2 an CO) exposed symptomatic patients [67], when standard spirometry showed no change in pulmonary function.…”

Effects of Renewable Diesel Exhaust on Lung Function and Self-rated Symptoms for Healthy Volunteers in a Human Chamber Exposure Study&nbsp;

“…Reduced PNIF is not a measure of lung function, but clinically a long-term nasal obstruction caused by occupational exposure could be considered indicative for the development of irritation asthma (52). In previous studies, oscillometry measurements found early manifestations of lung disease before these were measurable with spirometry (53,54). The subjects with baseline oscillometric values just outside the normal range ("atypical group", Additional file A) were hence hypothesized to have a different lung reaction than persons within the normal range.…”