Impedance Cardiography in the Measurement of Cardiac Output: Studies in Rabbits

Pappas, Christos G.; Wang, Xiang; Connolly, Raymond J.; Schwaitzberg, Steven D.

doi:10.1006/jsre.1995.1199

Cited by 3 publications

(1 citation statement)

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“…Contrast agents were injected through the marginal ear vein, with a total injection volume of 2 mL composed of ([gadopiclenol or gadoterate meglumine dose + saline up to 1 mL] + [1 mL physiological serum = flush]). The injection rate was 0.25 mL/s (automatic injector, PHD 2000, Harvard Apparatus), corresponding to 2 mL/s in humans (cardiac output ratio equal to 8 between rabbits and humans [15][16][17] ) (Fig. 1A).…”

Section: Rabbit Studymentioning

confidence: 99%

Evaluation of the Contrast Enhancement Performance of Gadopiclenol for Magnetic Resonance Angiography in Healthy Rabbits and Pigs

Hugon,

Adriaensen,

Wintrebert

et al. 2024

Invest Radiol

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Objectives Unexpected accumulations of gadolinium in various organs were reported after the administration of gadolinium-based contrast agents, making desirable to reduce the dose while maintaining equivalent diagnostic performance. The aim of this study was to evaluate the contrast enhancement performance of high relaxivity gadopiclenol compared with gadoterate meglumine in abdominal contrast-enhanced magnetic resonance angiography (CE-MRA). Materials and Methods In a first study in healthy rabbits, axial 3D gradient echo sequences were applied at 4.7 T to study arterial enhancement as a function of gadopiclenol dose (0.025, 0.05, 0.075, and 0.1 mmol Gd/kg) or gadoterate meglumine at 0.1 mmol Gd/kg (n = 5–6/group). The increase in signal-to-noise ratio (ΔSNR) in the aorta at the first pass was measured and compared. In a second, crossover study in 6 healthy pigs, abdominal CE-MRA sequences were acquired at 3 T with gadopiclenol at 0.05 mmol Gd/kg or gadoterate meglumine at 0.1 mmol Gd/kg at a 1-week interval. Quantitatively on the maximum intensity projection (MIP) images, the mean MIP SNR within the aorta of both groups was compared. Qualitatively, a blinded comparison of the angiograms was performed by an experienced radiologist to determine the preferred contrast agent. Results In the rabbit, ∆SNR is linearly correlated with the gadopiclenol dose (P = 0.0010). Compared with gadoterate meglumine 0.1 mmol Gd/kg, an increase in the ∆SNR is observed after 0.05, 0.075, and 0.1 mmol Gd/kg of gadopiclenol (+63% P = 0.0731, +78% P = 0.0081, and +72% P = 0.0773, respectively), whereas at 0.025 mmol Gd/kg, ∆SNR is in the same range as with gadoterate meglumine 0.1 mmol Gd/kg (+15% P > 0.9999). In pigs, contrast enhancement after gadopiclenol at 0.05 mmol/kg is +22% superior to MIP SNR after gadoterate meglumine at 0.1 mmol Gd/kg (P = 0.3095). Qualitatively, a preference was shown for gadopiclenol images (3/6) over the gadoterate meglumine examinations (1/6), with no preference being shown for the remainder (2/6). Conclusions First-pass CE-MRA is feasible with gadopiclenol at 0.05 mmol Gd/kg with at least the same arterial signal enhancement and image quality as gadoterate meglumine at 0.1 mmol Gd/kg.

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Section: Rabbit Studymentioning

confidence: 99%

Evaluation of the Contrast Enhancement Performance of Gadopiclenol for Magnetic Resonance Angiography in Healthy Rabbits and Pigs

Hugon,

Adriaensen,

Wintrebert

et al. 2024

Invest Radiol

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Hemodynamic Monitoring in Thoracic Surgical Patients

Hillenbrand¹,

Thiele²

2022

Cohen's Comprehensive Thoracic Anesthesia

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A meta-analysis of three decades of validating thoracic impedance cardiography

Raaijmakers

Faes

Scholten

et al. 1999

Critical Care Medicine

139

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The overall r2 value of .67 indicates that TIC might be useful for trend analysis of different groups of patients. However, for diagnostic interpretation, a r2 value of .53 might not meet the required accuracy of the study. Great care should be taken when TIC is applied to the cardiac patient. However, because the applied reference method was of significant influence, differences between TIC and the reference method are incorrectly attributed to errors in TIC alone.

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Impedance Cardiography in the Measurement of Cardiac Output: Studies in Rabbits

Cited by 3 publications

References 0 publications

Evaluation of the Contrast Enhancement Performance of Gadopiclenol for Magnetic Resonance Angiography in Healthy Rabbits and Pigs

Evaluation of the Contrast Enhancement Performance of Gadopiclenol for Magnetic Resonance Angiography in Healthy Rabbits and Pigs

Hemodynamic Monitoring in Thoracic Surgical Patients

A meta-analysis of three decades of validating thoracic impedance cardiography

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