Impedance-based outflow boundary conditions for human carotid haemodynamics

Malvè, Mauro; Chandra, Santanu; García, A.; Mena, A.; Martı́nez, Miguel Ángel; Finol, Ender A.; Doblaré, M.

doi:10.1080/10255842.2012.744396

Cited by 42 publications

(33 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The branching point is the focus of elevated shear-stress. This elevated tension occurs at the junction between the internal carotid artery, supplying the low-pressure cerebral circulation, and the external carotid branch, providing blood to the high resistance facial muscles [ 8 ]. This vulnerable region is well suited for imaging evaluation and provides an ideal surrogate for other vascular beds.…”

Section: Introductionmentioning

confidence: 99%

Advanced MRI for carotid plaque imaging

Singh

Moody

Roifman

et al. 2015

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

Atherosclerosis is the ubiquitous underling pathological process that manifests in heart attack and stroke, cumulating in the death of one in three North American adults. High-resolution magnetic resonance imaging (MRI) is able to delineate atherosclerotic plaque components and total plaque burden within the carotid arteries. Using dedicated hardware, high resolution images can be obtained. Combining pre- and post-contrast T1, T2, proton-density, and magnetization-prepared rapid acquisition gradient echo weighted fat-saturation imaging, plaque components can be defined. Post-processing software allows for semi- and fully automated quantitative analysis. Imaging correlation with surgical specimens suggests that this technique accurately differentiates plaque features. Total plaque burden and specific plaque components such as a thin fibrous cap, large fatty or necrotic core and intraplaque hemorrhage are accepted markers of neuroischemic events. Given the systemic nature of atherosclerosis, emerging science suggests that the presence of carotid plaque is also an indicator of coronary artery plaque burden, although the preliminary data primarily involves patients with stable coronary disease. While the availability and cost-effectiveness of MRI will ultimately be important determinants of whether carotid MRI is adopted clinically in cardiovascular risk assessment, the high accuracy and reliability of this technique suggests that it has potential as an imaging biomarker of future risk.

show abstract

Section: Introductionmentioning

confidence: 99%

Advanced MRI for carotid plaque imaging

Singh

Moody

Roifman

et al. 2015

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

show abstract

“…Fluid-structure interaction (FSI) between the blood flow and the arterial-wall deformation in various arteries has been widely investigated. Malvé et al compared the computational results between rigid and compliant arterial walls and showed that WSS distributions are similar for both CFD and FSI simulations, while qualitative discrepancies in the WSS distribution and relevant differences in the WSS temporal profiles are also available, especially in the areas characterized by high displacement [34]. The temporal variation of WSS shows lower WSS values computed with FSI simulation than the CFD analysis.…”

Section: Discussionmentioning

confidence: 84%

Numerical Simulation of Vertebral Artery Stenosis Treated With Different Stents

Qiao

Zhang

2014

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

We sought to investigate the effects of endovascular stents with different links for treating stenotic vertebral artery and to determine the relationship between the shape of the link and in-stent restenosis (ISR). We also attempted to provide scientific guidelines for stent design and selection for clinical procedures. Models of three types of stent with different links (L-stent, V-stent, and S-stent) and an idealized stenotic vertebral artery were established. The deployment procedure for the stent in the stenotic vertebral artery was simulated for solid mechanics analysis. Next, the deformed models were extracted to construct the blood flow domain, and numerical simulations of the hemodynamics in these models were performed using the finite element method. The numerical results demonstrated that: (1) Compared with the L-stent and V-stent, the S-stent has a better flexibility and induces less stress in the stent strut. Furthermore, less stress is generated in the arterial wall. (2) Vascular straightening is scarcely influenced by the shape of the link, but it is closely related to the flexibility of the stent. (3) The S-stent has the smallest foreshortening among the three types of stents. (4) Compared with the V-stent and S-stent, the L-stent causes a smaller area with low wall shear stress, less blood stagnation area, and better blood flow close to the artery wall. From the viewpoint of the combination of solid mechanics and hemodynamics, the S-stent has better therapeutic effects because of its lower potential for inducing ISR and its better prospects in clinical applications compared with the L-stent and V-stent.

show abstract

“…Para el cálculo del flujo sanguíneo, se han empleado las ecuaciones de continuidad y de Navier-Stokes, además de realizar el cálculo de varios ciclos cardiacos en estado transitorio a partir de condiciones de contorno de arterias carótidas [2], y la aplicación de la Ley de Murray para la distribución de flujo en las bifurcaciones.…”

Section: Modelo Matemáticounclassified

“…Crecimiento de placa de ateroma en arteria carótida de paciente específico según diferentes estímulos mecánicos Patricia Hernández López 1 , Myriam Cilla Hernández 1,2,3 , Miguel Ángel Martínez 1,3 Barca, Estefanía Peña Baquedano 1,3 1 Applied Mechanics and Bioengineering (AMB) Instituto de Investigación en Ingeniería de Aragón (I3A) Universidad de Zaragoza, Mariano Esquillor s/n, 50018, Zaragoza, Spain.…”

unclassified