Impairments of speech fluency in Lewy body spectrum disorder

Ash, Sharon; McMillan, Corey T.; Gross, Rachel G.; Cook, Philip A.; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

doi:10.1016/j.bandl.2011.09.004

Cited by 52 publications

(69 citation statements)

References 61 publications

(74 reference statements)

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“…Similarly, the grammatical expression, characterized by a reduction of well-formed sentences and of dependent clauses, is significantly compromised in persons with PDD and LBD, but not in non-demented PD patients (Ash et al, 2011, 2012b; Ash and Grossman, 2015). Speech rate appears to be useful in distinguishing PDD from LBD, with persons with PDD being less impaired and producing a higher average of words per minute (Ash et al, 2011, 2012b).…”

Section: Results: Relevant Features and Linguistic Profiles Of The Mamentioning

confidence: 99%

Connected Speech in Neurodegenerative Language Disorders: A Review

et al. 2017

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Language assessment has a crucial role in the clinical diagnosis of several neurodegenerative diseases. The analysis of extended speech production is a precious source of information encompassing the phonetic, phonological, lexico-semantic, morpho-syntactic, and pragmatic levels of language organization. The knowledge about the distinctive linguistic variables identifying language deficits associated to different neurodegenerative diseases has progressively improved in the last years. However, the heterogeneity of such variables and of the way they are measured and classified limits any generalization and makes the comparison among studies difficult. Here we present an exhaustive review of the studies focusing on the linguistic variables derived from the analysis of connected speech samples, with the aim of characterizing the language disorders of the most prevalent neurodegenerative diseases, including primary progressive aphasia, Alzheimer's disease, movement disorders, and amyotrophic lateral sclerosis. A total of 61 studies have been included, considering only those reporting group analysis and comparisons with a group of healthy persons. This review first analyzes the differences in the tasks used to elicit connected speech, namely picture description, story narration, and interview, considering the possible different contributions to the assessment of different linguistic domains. This is followed by an analysis of the terminologies and of the methods of measurements of the variables, indicating the need for harmonization and standardization. The final section reviews the linguistic domains affected by each different neurodegenerative disease, indicating the variables most consistently impaired at each level and suggesting the key variables helping in the differential diagnosis among diseases. While a large amount of valuable information is already available, the review highlights the need of further work, including the development of automated methods, to take advantage of the richness of connected speech analysis for both research and clinical purposes.

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Section: Results: Relevant Features and Linguistic Profiles Of The Mamentioning

confidence: 99%

Connected Speech in Neurodegenerative Language Disorders: A Review

et al. 2017

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“…Decreased speech rate has also been documented in non-aphasic patients with behavioral variant frontotemporal degeneration (Ash et al, 2006) and amyotrophic lateral sclerosis (Ash et al, 2015). We have previously shown that patients with PDSD have reduced speech fluency as well (Ash et al, 2012). In the present study, speech rate was impaired in DEM but not in NON-DEM, and moreover speech rate declined from Time 1 to Time 2 in DEM.…”

Section: Discussionmentioning

confidence: 99%

“…It has become clear in more recent studies that some aspects of language receive bilateral support. For example, speech rate recently has been associated with bilateral frontal regions, particularly in individuals who are aging or have a neurodegenerative disease (Ash et al, 2012; Grossman et al, 2013; van Oers et al, 2010). In the present study, we investigate whether atrophy at baseline in brain regions important for language predicts longitudinal speech production deficits in PDSD.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal decline in speech production in Parkinson's disease spectrum disorders

et al. 2017

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We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), and we related increasing impairment to structural brain changes in specific language and motor regions. Patients provided semi-structured speech samples, describing a standardized picture at two time points (mean±SD interval=38±24 months). The recorded speech samples were analyzed for fluency, grammar, and informativeness. PDSD patients with dementia exhibited significant decline in their speech, unrelated to changes in overall cognitive or motor functioning. Regression analysis in a subset of patients with MRI scans (n=11) revealed that impaired language performance at Time 2 was associated with reduced gray matter (GM) volume at Time 1 in regions of interest important for language functioning but not with reduced GM volume in motor brain areas. These results dissociate language and motor systems and highlight the importance of non-motor brain regions for declining language in PDSD.

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“…According to the team, the speech of PD patients is characterized by pauses in sentences now and then. Examining grammatical aspects of language, namely sentence processing in patients with PDD and LB, Grossman et al's (2012) study deonstrated that there is a selectively slow processing of lengthened ambitious sentences in the two subtypes of dementia. Conclusions to be drawn from such studies need much more investigation.…”

Section: Introductionmentioning

confidence: 99%

“…Such guidelines, however, encouraged many researchers to investigate the relationship between language and dementia types. Testing the speech in demented and non-demented patients with PD, the study of Ash et al, (2012) concluded that speech fluency is reduced in these patients. According to the team, the speech of PD patients is characterized by pauses in sentences now and then.…”

Section: Introductionmentioning

confidence: 99%

Cortical & Subcortical Dementias: A Psychoneurolinguistic Perspective

Al-Yaari

Hammadi²,

Alyami³

2013

IJELE

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Background: A rapidly increasing number of studies that focus on the relationship between language and cortical (CD) and subcortical dementias (SCD) have recently shown that such correlation is existent. Mounting evidence suggests that cognitive impairments should be investigated against language disorders. Aims:This study aims at investigating how language is associated with dementia diseases namely CD &SCD in light of psychoneurolinguistic approach.

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Impairments of speech fluency in Lewy body spectrum disorder

Cited by 52 publications

References 61 publications

Connected Speech in Neurodegenerative Language Disorders: A Review

Connected Speech in Neurodegenerative Language Disorders: A Review

Longitudinal decline in speech production in Parkinson's disease spectrum disorders

Cortical & Subcortical Dementias: A Psychoneurolinguistic Perspective

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