Impairments of Colour Vision Induced by Organic Solvents: A Meta-Analysis Study

Paramei, Galina V.; Meyer-Baron, Monika; Seeber, Andreas

doi:10.1016/j.neuro.2004.01.006

Cited by 69 publications

(62 citation statements)

References 52 publications

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“…Since the D-15d test is extensively used in clinical practice and is also convenient for field work in research on color vision due to its portability and accessible cost, we re-examined its usefulness here for the assessment of color vision losses in this group of workers who had been exposed to mercury vapor. The D-15d test was designed by Lanthony in 1978 for screening acquired color vision loss (6,7) and has been frequently used in neurotoxicologic examinations of the effects of exposure to solvents and other occupational or environmental toxicants (1)(2)(3)(4)8). The D-15 test was designed by Farnsworth in 1943 for screening congenital and acquired color vision deficiencies and is effective in separating subjects with severe congenital deficiencies from normal and slightly defective observers (9,10).…”

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“…For the worst eye, 54.2% (13/24 eyes) of the patients had color vision defects as well as tritan losses. According to Paramei et al (8), Kollner's rule indicates that tritan losses -in a toxic retinopathy -are present in outer retina dysfunction, and, in a more advanced stage, predominantly associated with high level and long-term exposure, the losses are diffuse with damage affecting the inner retina and optic nerve. Since we have no information about color vision during the time of exposure and these patients have been away from the occupational environment for more than one year, the damage of color discrimination may be irreversible for them.…”

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Long-term loss of color vision after exposure to mercury vapor

Feitosa-Santana¹,

Costa²,

Lago³

et al. 2007

Braz J Med Biol Res

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We evaluated the color vision of 24 subjects (41.6 ± 6.5 years; 6 females) who worked in fluorescent lamp industries. They had been occupationally exposed to mercury vapor (10.6 ± 5.2 years) and had been away from the source of exposure for 6.4 ± 4.04 years. Mean urinary concentration of mercury was 40.6 ± 36.4 µg/g creatinine during or up to 1 year after exposure and 2.71 ± 1.19 µg/g creatinine at the time of color vision testing or up to 1 year thereafter. All patients were diagnosed with chronic mercury intoxication, characterized by clinical symptoms and neuropsychological alterations. A control group (N = 36, 48.6 ± 11.9 years, 10 females, 1.5 ± 0.47 µg mercury/g creatinine) was subjected to the same tests. Inclusion criteria for both groups were Snellen VA 20/30 or better and absence of known ophthalmologic pathologies. Color discrimination was assessed with the Farnsworth D-15 test (D-15) and with the Lanthony D-15d test (D15d). Significant differences were found between the two eyes of the patients (P < 0.001) in both tests. Results for the worst eye were also different from controls for both tests: P = 0.014 for D-15 and P < 0.001 for D-15d. As shown in previous studies, the D-15d proved to be more sensitive than the D-15 for the screening and diagnosis of the color discrimination losses. Since color discrimination losses were still present many years after the end of exposure, they may be considered to be irreversible, at least under the conditions of the present study.

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confidence: 99%

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Long-term loss of color vision after exposure to mercury vapor

Feitosa-Santana¹,

Costa²,

Lago³

et al. 2007

Braz J Med Biol Res

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“…Im Ergebnis wurde der CCI (color confusion index) auf der Basis des Lanthony-D15-Tests als nicht vertrauenswürdig eingestuft, da mit Wiederholung des Tests die Ergebnisse besser wurden. Weder Expositionshöhe noch -dauer von Toluol korrelierten mit der Effektstärke [114]. Daher wird dieser Effekt für eine Ableitung von Richtwerten für Toluol nicht weiter berücksichtigt.…”

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Richtwerte für Toluol und gesundheitliche Bewertung von C7-C8-Alkylbenzolen in der Innenraumluft

2016

Bundesgesundheitsbl

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“…Thus, workers in the lamination process of the FRP manufacturing industry are still a high risk group for exposure to styrene in Korea (Cho et al, 2008). Various studies on possible adverse health effects on workers exposed to styrene have been reported such as neurotoxic effects on color vision (Paramei et al, 2004), the peripheral and autonomic nervous system (Yuasa et al, 1996), neurobehavioral performance and the vibration perception threshold (Sato et al, 2009). During styrene's human metabolic process, approximately 85% of the inhaled amount is eliminated as mandelic acid(MA) in urine, 10% as phenylglyoxylic acid(PGA), and 1% as styrene in exhalation (ACGIH, 2001).…”

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confidence: 99%