Impairments in proprioceptively-referenced limb and eye movements in chronic stroke

Abstract

Background: Upper limb proprioceptive impairments are common after stroke and can affect daily function. Recent work has shown that stroke survivors have difficulty using visual information to improve proprioception. It is unclear how eye movements are impacted to guide action of the arm after stroke. Here, we aimed to understand how upper limb proprioceptive impairments impact eye movements in individuals with stroke. Methods: Control (N=20) and stroke participants (N=20) performed a proprioceptive matching task with upper limb and eye movements. A KINARM exoskeleton with eye tracking was used to assess limb and eye kinematics. The upper limb was passively moved by the robot and participants matched the location with either an arm or eye movement. Accuracy was measured as the difference between passive robot movement location and the active limb matching (Hand-End Point Error) or the active eye movement matching (Eye-End Point Error). Results: We found that individuals with stroke had significantly larger Hand and Eye-End Point Errors compared to controls. Further, we found that stroke participants had proprioceptive errors of the hand and eye were highly correlated [r=0.67, p=0.001], a relationship not observed for controls. Conclusions: Eye movement accuracy declined as a function of proprioceptive impairment of the more-affected limb, which was used as a proprioceptive reference. The inability to use proprioceptive information of the arm to coordinate eye movements suggests that disordered proprioception impacts integration of sensory information across different modalities. These results have important implications for how vision is used to actively guide limb movement during rehabilitation.