Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis.

Butt, Allen E.; Noble, Michelle M.; Rogers, June; Rea, Thomas E.

doi:10.1037/0735-7044.116.2.241

Cited by 20 publications

(19 citation statements)

References 69 publications

(149 reference statements)

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“…Consistent with these results, the LS is positioned at an essential node point for integrating cognitive information from the various brain regions, including the prefrontal cortex, and relaying it to diencephalic and mesencephalic regions to directly control behavioral responses (Sheehan et al, 2004). Furthermore, the LS and MS have reciprocal connections with the nucleus of basalis of Meynert (substantia innominata; Lamour et al, 1984), which is involved in negative patterning similar to that (Tone1 + Light1) in the present study (Butt et al, 2002). Taken together, the existence of CS 0 -related neurons in the LS suggests that cognitive information from the prefrontal cortex and the nucleus of basalis of Meynert may exert inhibitory control on emotional and motivational behaviors through the LS.…”

Section: Discussionsupporting

confidence: 69%

Reward Contingency Modulates Neuronal Activity in Rat Septal Nuclei during Elemental and Configural Association Tasks

Matsuyama¹,

Uwano²,

Hori³

et al. 2011

Front. Behav. Neurosci.

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It has been suggested that septal nuclei are important in the control of behavior during various reward and non-reward situations. In the present study, neuronal activity was recorded from rat septal nuclei during discrimination of conditioned sensory stimuli (CSs) of the medial forebrain bundle associated with or without a reward (sucrose solution or intracranial self-stimulation, ICSS). Rats were trained to lick a spout protruding close to the mouth just after a CS to obtain a reward stimulus. The CSs included both elemental and configural stimuli. In the configural condition, the reward contingency of the stimuli presented together was opposite to that of each elemental stimulus presented alone, although the same sensory stimuli were involved. Of the 72 responsive septal neurons, 18 responded selectively to the CSs predicting reward (CS+-related), four to the CSs predicting non-reward (CS0-related), nine to some CSs predicting reward or non-reward, and 15 non-differentially to all CSs. The remaining 26 neurons responded mainly during the ingestion/ICSS phase. A multivariate analysis of the septal neuronal responses to elemental and configural stimuli indicated that septal neurons encoded the CSs based on reward contingency, regardless of the stimulus physical properties and were categorized into three groups; CSs predicting the sucrose solution, CSs predicting a non-reward, and CSs predicting ICSS. The results suggest that septal nuclei are deeply involved in discriminating the reward contingency of environmental stimuli to manifest appropriate behaviors in response to changing stimuli.

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Section: Discussionsupporting

confidence: 69%

Reward Contingency Modulates Neuronal Activity in Rat Septal Nuclei during Elemental and Configural Association Tasks

Matsuyama¹,

Uwano²,

Hori³

et al. 2011

Front. Behav. Neurosci.

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“…In contrast, Butt and co-workers have reported that either excitotoxic lesions of the NBM, or selective cholinergic lesions of the NBM using 192IgG-SAP, can significantly impair acquisition of a negative patterning task, without producing impairment on a similar transverse patterning task (Butt and Bowman, 2002;Butt and Hodge, 1997;Butt, Noble, Rogers, and Rea, 2002). There are several possible explanations for the disagreement between these results.…”

Section: Effects On Ca Acquisitioncontrasting

confidence: 45%

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy

Gibbs

Johnson

2007

Neurobiology of Learning and Memory

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Abstract192 IgG-saporin (SAP) was used to selectively destroy cholinergic neurons in the rostral basal forebrain (e.g., medial septum (MS) and vertical limb of the diagonal band of Broca (VDB)) and/or the caudal basal forebrain (e.g., nucleus basalis magnocellularis (NBM)) of ovariectomized SpragueDawley rats. The effects of these lesions on two different cognitive tasks, a delayed matching to position (DMP) T-maze task, and a configural association (CA) operant conditioning task, were evaluated and compared. Injecting SAP into either the MS or NBM significantly impaired acquisition of the DMP task. Analysis showed that the effects were due largely to an affect on response patterns adopted by the rats during training, as opposed to an effect on working memory performance. Notably, the impairment in DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. Despite the deficit, most animals eventually learned the task and reached criterion; however by the end of training, controls and animals that received SAP into either the MS or NBM appeared more likely to use an allocentric place strategy to solve the task, whereas animals that received SAP into both the MS and NBM were more likely to use an egocentric response strategy. Cholinergic lesions also produced a small but significant affect on acquisition of the CA task, but only with respect to response time, and only in the SAP-NBM-treated animals. SAP-NBM lesions also produced small but significant impairments in both the number of responses and response time during the acquisition of simple associations, possibly reflecting an effect on alertness or attention. Notably, the effects on CA acquisition were small, and like the effects on DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. We conclude that selective basal forebrain cholinergic lesions produce learning deficits that are task specific, and that cholinergic denervation of either the frontal cortex or hippocampus can affect response patterns and strategy in ways that affect learning, without necessarily reflecting deficits in working memory performance.

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“…These capacities are acquired during development as a result of synaptic maturation in the sensory circuit and can be improved by training in adulthood (Sanes and Woolley, 2011). Lesions of cortical cholinergic fibers can result in decreased detection, identification, and localization of stimuli and impaired learning, storage, and flexible retrieval of sensory associations (Berger-Sweeney et al, 2000; Butt et al, 2002; Cabrera et al, 2006; Leach et al, 2013; Vale-Martinez et al, 2002). …”

Section: Improving Perception By Manipulating Neuromodulationmentioning

confidence: 99%

Cortical Plasticity, Excitatory–Inhibitory Balance, and Sensory Perception

Carcea

Froemke

2013

Progress in Brain Research

110

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Experience shapes the central nervous system throughout life. Structural and functional plasticity confers a remarkable ability on the brain, allowing neural circuits to adequately adapt to dynamic environments. This process can require selective adjustment of many excitatory and inhibitory synapses in an organized manner, in such a way as to enhance representations of behaviorally important sensory stimuli while preserving overall network excitability. The rules and mechanisms that orchestrated these changes across different synapses and throughout neuronal ensembles are beginning to be understood. Here, we review the evidence connecting synaptic plasticity to functional plasticity and perceptual learning, focusing on the roles of various neuromodulatory systems in enabling plasticity of adult neural circuits. However, the challenge remains to appropriately leverage these systems and forms of plasticity to persistently improve perceptual abilities and behavioral performance.

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Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis.

Cited by 20 publications

References 69 publications

Reward Contingency Modulates Neuronal Activity in Rat Septal Nuclei during Elemental and Configural Association Tasks

Reward Contingency Modulates Neuronal Activity in Rat Septal Nuclei during Elemental and Configural Association Tasks

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy

Cortical Plasticity, Excitatory–Inhibitory Balance, and Sensory Perception

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