Impairments in metabolism of amino acids — precursors of gasotransmitters — in the premature birth

Mikhelson, A.A.; Pogorelova, T. N.; Gunko, V. O.; Никашина, А. А.; Palieva, N.V.

doi:10.18097/pbmc20216705443

Cited by 2 publications

(2 citation statements)

References 14 publications

(7 reference statements)

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“…Furthermore, a reduction in H 2 S causes oxidative stress. H 2 S is a gasotransmitter; gasotransmitters are defined as small, endogenous molecules that play an active role in regulating intracellular and intercellular signaling systems and in neuromodulation 67,131,132 . H 2 S behaves as an antioxidant and potentially possesses influence in regulating oxidative stress in chronic hypoxia caused PH 133 .…”

Section: Resultsmentioning

confidence: 99%

Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery

Fayad

Sellke

Feng

2022

Journal of Cardiac Surgery

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Background and Aim Pulmonary hypertension (PH) is frequently associated with cardiovascular surgery and is a common complication that has been observed after surgery utilizing cardiopulmonary bypass (CPB). The purpose of this review is to explain the characteristics of PH, the mechanisms of PH induced by cardiac surgery and CPB, treatments for postoperative PH, and future directions in treating PH induced by cardiac surgery and CPB using up‐to‐date findings. Methods The PubMed database was utilized to find published articles. Results There are many mechanisms that contribute to PH after cardiac surgery and CPB which involve pulmonary vasomotor dysfunction, cyclooxygenase, the thromboxane A2 and prostacyclin pathway, the nitric oxide pathway, inflammation, and oxidative stress. Furthermore, there are several effective treatments for postoperative PH within different types of cardiac surgery. Conclusions By possessing a deep understanding of the mechanisms that contribute to PH after cardiac surgery and CPB, researchers can develop treatments for clinicians to use which target the mechanisms of PH and ultimately reduce and/or eliminate postoperative PH. Additionally, learning about the most up‐to‐date studies regarding treatments can allow clinicians to choose the best treatments for patients who are undergoing cardiac surgery and CPB.

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Section: Resultsmentioning

confidence: 99%

Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery

Fayad

Sellke

Feng

2022

Journal of Cardiac Surgery

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“…PE is considered as a sign of cellular apoptosis [ 36 ], while PC is a constitutive plasma membrane lipid and the major transport form of DHA in plasma [ 37 ]. The imbalance of amino acids in the fetoplacental system in PTB is accompanied by a change in the production of their low molecular weight derivatives gas transmitters (NO, CO) [ 38 ]. Previous studies have reported on amino acids and acylcarnitines being potential markers of gestational age [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening

Yan

et al. 2022

Reprod Biol Endocrinol

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Background Preterm birth (PTB) is the primary cause of infant morbidity and mortality. Moreover, previous studies have established that PTB is related to premature cervical ripening. However, the underlying mechanism remains to be elucidated. This study sought to identify differentially expressed metabolites and investigate their potential biological functions in PTB. Methods Pregnant C57BL/6 J mice were treated with either LPS or normal saline and cervical alterations before labor were detected by staining. Metabolic profiles in the plasma of PTB and control mice were examined through non-targeted metabonomics analyses, quantitative polymerase chain reaction and immunofluorescence staining were performed on human cervical smooth cells. Results The study demonstrated that the mRNA and protein levels of α-SMA, SM-22, and calponin in cervical smooth muscle cells of PTB mice were lower while OR was higher at both mRNA and protein levels compared to the CTL group. A total of 181 differentially expressed metabolites were analyzed, among them, 96 were upregulated, while 85 were downregulated in the PTB group. Differentially expressed metabolites may play a role in STAT3, RhoA, mTOR, TGF-β, and NK-κB signaling pathways. Furthermore, when treated with taurine, the levels of α-SMA and SM-22 in human cervical smooth muscle cells were elevated, whereas that of connexin-43 was decreased. Conclusion Our study highlighted the changes of metabolites in the peripheral blood changed prior to PTB and revealed that these differentially expressed metabolites might participate in the development of premature cervical ripening. Taurine was identified as an important metabolite may modulate human cervical smooth muscle cells. Our study provided new insights into the mechanism underlying premature cervical ripening in PTB.

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Impairments in metabolism of amino acids — precursors of gasotransmitters — in the premature birth

Cited by 2 publications

References 14 publications

Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery

Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery

Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening

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