Impairment of Vocal Expression of Negative Emotions in Patients with Alzheimerâ€™s Disease

Han, Kap Su; Zaytseva, Yuliya; Bao, Yan; Pöppel, Ernst; Chung, Sun Yong; Kim, Jong Woo; Kim, Hyun Taek

doi:10.3389/fnagi.2014.00101

Cited by 11 publications

(12 citation statements)

References 33 publications

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“…pitch) abilities contribute to prosodic processing more generally, it also offers a more general proof-of-concept for a new approach to the cognitive neuroscience of neuropsychiatric illnesses.Illnesses like schizophrenia are increasingly appreciated as being heterogeneous innature,and abnormal behavior such as prosody perception may be impaired in some individuals, but not in others. Additionally, many of the socio-cognitive markers such as impaired prosody perception that present in schizophrenia are not specific to the illness, and alsopresent in other disorders such as autism, Alzheimer"s disease, bipolar disorder, and Parkinson"s disease (42)(43)(44)(45)(46). From a neuroscience perspective, the ability to perceive social intent through prosody is a highly complex event involvingmany cortical and subcortical brain regions (47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

What rhythmic perception and amusia can tell us about vocal social communication in schizophrenia

Rlc

Gamez

Bolgar

et al. 2016

Preprint

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Background: Perceiving social intent throughvocal intonation is impaired in schizophrenia; thisdysprosodia partly arisingfrom impaired pitch perception.Individuals with amusia (tone-deafness) are insensitive to pitch change andalso demonstrate prosody deficits. Sensitivity to rhythm is reduced in amusia when tonal sequences contain pitch changes (polytonic), but is normal for monotonic sequences, suggestingperceptual impairment originates at a secondary processing stage where pitch-and timerelatedcues are yoked.Here, we sought to ascertain: 1) whether schizophreniapatients demonstrate rhythmic deficits, 2) whether suchdeficits are restricted to polytonic sequences, and 3) how pitch and rhythm perception relate to prosodic processing.Methods: Seventy-sixparticipants (33 schizophrenia) completed tasks assessing pitch and prosody perception, as well as monotonic and polytonic rhythmic perception. Results: Increasing tone-deafness correlated with pitch-dependent rhythm detection impairments. Pitch and prosody correlated across all participants. Schizophreniapatients displayed basic time and pitch deficits. Correlations and path analyses indicated prosodic processing is an associatedfunction of pitch and pitch-dependent rhythm perception,with pure temporal processing playing an indirect role.In schizophrenia, deficits in monotonic and polytonic rhythmic perception did not contribute to prosodic processing dysfunction, and montonic rhythmic dysfunction and pitch perception did not covary. Conclusions: Exploring similarities between amusia and schizophrenia focused our characterization of prosodic processing as the function of sub-processes reflecting pitch and time perception,whichare prerequisite for prosodic processing. The uniqueness of dysprosodia in schizophrenia relative to other illnesses may be measured by idiosyncrasy in the pattern and magnitude of the sub-process task relationships.

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Section: Discussionmentioning

confidence: 99%

What rhythmic perception and amusia can tell us about vocal social communication in schizophrenia

Rlc

Gamez

Bolgar

et al. 2016

Preprint

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“…Alzheimer's disease (AD), a global health problem with a high prevalence rate, has been recognized as a neurodegenerative disease characterized by progressive cognitive impairment (e.g., memory loss) and neuropsychiatric symptoms (e.g., impairment of vocal expression of emotions) during aging (Han et al, ). Owing to the growth of the aging population, the incidences of AD and other dementias are increasing rapidly.…”

Section: Some Clock‐related Diseasesmentioning

confidence: 99%

Biological clocks, some clock‐related diseases, and medicinal plants

Deng

2018

PsyCh Journal

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Progress in chronobiology thus far has been built on botanical field investigation records, experiments on the development of biological clocks, open questions, established rules, and molecular mechanisms. In this review, three clock-related diseases, namely cancer, Alzheimer's disease (AD), and depression, are discussed. Evidence-based mechanisms of action of active compounds, namely epigallocatechin-3-gallate (EGCG), curcumin, and melatonin, from three medicinal plants, Camellia sinensis K., Curcuma longa L., andHypericum perforatum L., respectively, as potential therapies against cancer, AD, and depression, respectively, have been explained. Feedback loops of basic inputs and application outputs of various studies will lead to the development of chronobiology for applications in time-keeping, disease prevention, and control, and future agricultural practices.

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“…In AD, a few studies reported reduced expression of emotions, 18 , 19 and this reduction correlated with cognitive impairment across multiple domains, including memory and attention. 18 While no study exists for DLB, reports on emotional expression alterations in Parkinson's disease (PD), another form of the Lewy body spectrum disorder, are abundant. 9 Alterations in vocal and facial expressions of emotions in PD are likely attributed to parkinsonian motor impairments, specifically hypokinetic dysarthria and facial bradykinesia, 9 although several studies have also suggested associations with executive dysfunction and alterations in the affective process.…”

Section: Introductionmentioning

confidence: 99%

Vocal expression of emotions discriminates dementia with Lewy bodies from Alzheimer's disease

Kobayashi,

Yamada,

Shinkawa

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), the two most common neurodegenerative dementias, both exhibit altered emotional processing. However, how vocal emotional expressions alter in and differ between DLB and AD remains uninvestigated. We collected voice data during story reading from 152 older adults comprising DLB, AD, and cognitively unimpaired (CU) groups and compared their emotional prosody in terms of valence and arousal dimensions. Compared with matched AD and CU participants, DLB patients showed reduced overall emotional expressiveness, as well as lower valence (more negative) and lower arousal (calmer), the extent of which was associated with cognitive impairment and insular atrophy. Classification models using vocal features discriminated DLB from AD and CU with an AUC of 0.83 and 0.78, respectively. Our findings may aid in discriminating DLB patients from AD and CU individuals, serving as a surrogate marker for clinical and neuropathological changes in DLB.Highlights DLB showed distinctive reduction in vocal expression of emotions. Cognitive impairment was associated with reduced vocal emotional expression in DLB. Insular atrophy was associated with reduced vocal emotional expression in DLB. Emotional expression measures successfully differentiated DLB from AD or controls.

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Impairment of Vocal Expression of Negative Emotions in Patients with Alzheimerâ€™s Disease

Cited by 11 publications

References 33 publications

What rhythmic perception and amusia can tell us about vocal social communication in schizophrenia

What rhythmic perception and amusia can tell us about vocal social communication in schizophrenia

Biological clocks, some clock‐related diseases, and medicinal plants

Vocal expression of emotions discriminates dementia with Lewy bodies from Alzheimer's disease

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