Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine

Reen, Rashmeet K.; Jamwal, Deshvir S.; Taneja, Subhash C.; Koul, Jawahar L.; Dubey, Raghvendra K.; Wiebel, Friedrich J.; Singh, Jaswant

doi:10.1016/0006-2952(93)90408-o

Cited by 101 publications

(52 citation statements)

References 28 publications

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“…However, the PPARα ligand has been reported to downregulate the expression of the UDP-glucose dehydrogenase (UGDH) gene. 33) Since piperine has also been reported to reduce UGDH mRNA and its activity in vivo and in vitro, 33,34) these observations would support the above hypothesis.…”

Section: Discussionmentioning

confidence: 71%

Piperine, a Pepper Ingredient, Improves the Hepatic Increase in Free Fatty Acids Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Ishida

Ishizaki

Tsutsumi

et al. 2008

JOURNAL OF HEALTH SCIENCE

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Dioxins, such as 2, 3,7,, are ubiquitous environmental pollutants. The variety of adverse effects produced by dioxins are a serious problem because they may affect humans and wild animals through the food chain. In this study, we examined the possible protective effects of piperine, which is a major alkaloid in black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.), on the toxic effects of TCDD in C57BL/6J mice. The repeated administration of high doses (30 and 45 mg/kg, 14 days, p.o.) of piperine alone produced a weak agonistic effect on the aryl hydrocarbon receptor, which was evaluated based on the increase in hepatic ethoxyresorufin O-deethylase (EROD) activity. No such effect was observed at the lowest dose (15 mg piperine/kg). However, while coadministration (20 mg/kg, 28 days, p.o.) of piperine with TCDD had no effect on TCDD-induced wasting syndrome, it improved the hepatic accumulation of free fatty acids produced by TCDD. In relation to this, the hepatic accumulation of triglycerides by TCDD also tended to be reduced by piperine. Despite the above effects, piperine failed to reduce the increase in hepatic EROD activity and lipid peroxidation produced by TCDD. These results suggest that piperine is a candidate to improve disorders of lipid metabolism produced by dioxins, although the mechanism remains to be clarified.

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Section: Discussionmentioning

confidence: 71%

Piperine, a Pepper Ingredient, Improves the Hepatic Increase in Free Fatty Acids Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Ishida

Ishizaki

Tsutsumi

et al. 2008

JOURNAL OF HEALTH SCIENCE

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“…Various mechanisms have been advanced in connection with bioactivity. The compound activates ions associated with pain-sensing nerve cells (McNamara, Randall, & Gunthorpe, 2005), and also inhibits enzymes involved with metabolism of xenobiotics (Bhardwaj, Glaser, Becquemont et al, 2002;Srinivasan, 2007), of drugs (Atal, Dubey, & Singh, 1985;Reen, Jamwal & Taneja, 1993) and of glucuronidation (Singh, Dubey, & Ata, 1986). A molecular mechanism is proposed for killing of breast cancer stem cells involving inhibition of Wnt signaling (Kakaral, Brenner, Khakaya et Vol.…”

Section: Piperinementioning

confidence: 99%

Unifying Mechanism for Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress

Kovacic¹,

Somanathan²

2017

GJHS

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A recent article deals with various nutrients in relation to bactericidal action. The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.

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“…Piperine inhibit pulmonary cytochrome P450 activities [92] Piperine inhibit UDP-glucose dehydrogenase and UDP-glucuronyl transferase [98] Piperine shows antileishmanic activity [155] Piperine increases serum response of β-carotene [100] Piperine inhibit alfatoxins B1 (AFB 1 )biosynthesis [156] Piperine shows antimalarial activity [157] Piperine reduced the production of alfatoxins [158] Thermogenic action of piperine via adrenal catecholamine secretion [159] Piperine inhibit monoamine oxidase [160] Piperine inhibit ascorbate-Fe ++ -induced lipid peroxidation [161] Piperine protected against oxidative stress induced carcinogenesis [162] Piperine modulated membrane dynamics and permeation characteristics [162] Piperine shows chemopreventive effectin carcinogenesis [163,164] Piperine inhibited mitochondrial oxidative phosphorylation [165] Piperine exerted protection against t-butyl hydroperoxide [166] Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 [167] Piperine potentiate hepatotoxicity of carbon tetrachloride in rats [168] Inhibition /quenching of super oxides and hydroxyl radicals by piperine [169] Piperine reduces high fat diet induced oxidative stress [170] Anti-metastatic activity of piperine on lung metastasis [171] Piperine inhibits platelet aggregation as a TXA 2 receptor antagonist [172] Piperine decreased mitochondrial lipid peroxidation [173] Piperine alleviates hypertension induced by NO synthase inhibition [174] Piperine reduced D-galactosamine induced hepatotoxicity [175] Piperine inhibited cholesteryl ester (CE) synthesis [176] Piperine enhances bioavailability of the tea polyphenol [177] Piperine shows anti mutagenic activity [178,179] Piperine shows anti-thyroid activity [180] Piperine modulates hormonal and apo lipoprotein profiles …”

Section: Different Effect Of Piperine Referencesmentioning

confidence: 99%

Piperine and Its Various Physicochemical and Biological Aspects: A Review

Chopra¹,

Dhingra²,

Kapoor³

et al. 2016

CHEM

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Abstract:Piper nigrum L. is examined as the king of species worldwide by virtue of its principle piperine. In Ayurveda, since from the ancient times, it is known as "Yogvahi". It is one of the important alkaloids of Pepper fruits (Family Piperaceae) and has been found to have numerous medicinal properties such as antioxidant, antiplatelet, anti-inflammatory, antihypertensive, hepatoprotective, antithyroid, antitumor, antiasthmatic activity and also have significant role as fertility enhancer. The present review discusses the biosynthetic pathway, extraction process, chemistry and various analytical methods of piperine. It also describes the structural modification of piperine and its various effects on biological system. The utility of piperine as a bioenhancer for certain antibacterialantibiotics and a potent inhibitor of drug metabolism are also discussed. Thus, review provides knowledgeable erudition on the piperine which paves way for further work.

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Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine

Cited by 101 publications

References 28 publications

Piperine, a Pepper Ingredient, Improves the Hepatic Increase in Free Fatty Acids Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Piperine, a Pepper Ingredient, Improves the Hepatic Increase in Free Fatty Acids Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Unifying Mechanism for Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress

Piperine and Its Various Physicochemical and Biological Aspects: A Review

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