Impairment of the Vasodilatation Capability of the Brachial Artery in Patients with Idiopathic Venous Thrombosis

Abstract

Aim: Determination of the functional capability of the peripheral arteries is increasingly used as an early marker of vessel disease. The aim of this study was to evaluate flow-mediated (FMD) and glyceryl trinitrate-mediated (NMD) dilation of the brachial artery in patients with idiopathic venous thrombosis (VT). Methods: Flow-mediated brachial artery dilatation and the dilatation response to glyceryl trinitrate were measured using high-resolution ultrasound in 97 subjects (49 eligible patients of both sexes, mean age 51.5 14.6 years, with idiopathic venous thrombosis, and 48 age-matched healthy controls).

Endothelial Dysfunction and Venous Thrombosis

“…We showed that idiopathic VT is associated with impaired flow-mediated and glycerin trinitrate-mediated vasodilatory response of the brachial artery. 26 This suggests a relationship between VTE and atherosclerosis. We also showed that idiopathic VT is associated with long-term increased levels of markers of endothelial damage (vWF and P-selectin).…”

“…Results from the MAinISar-THROmbosis registry suggested that arterial hypertension was an independent risk factor for recurrent VTE. 30 As in both diseases endothelial function deteriorates, 26,31 ED could be the link between these 2 diseases. This is in agreement with the reports of efficacy of some antihypertensive drugs on risk of VTE.…”

Testing Endothelial Function and its Clinical Relevance

“…All techniques for direct determination of venous endothelial function are complicated and their reproducibility is limited; therefore, measurement of endothelial function of the peripheral arteries is frequently used as a surrogate to assess venous endothelial function 52,53) . Namely, in subjects with deteriorated arterial endothelial function, venous endothelial dysfunction is also expected.…”

Utility of Noninvasive Endothelial Function Test for Prediction of Deep Vein Thrombosis After Total Hip or Knee Arthroplasty

“…11, 12 The vascular endothelium regulates the functional capabilities of the entire circulatory system; in patients with endothelial dysfunction of the peripheral arteries, the venous functional status may have deteriorated as well. [13][14][15] Reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a noninvasive, automatic, and less operator-dependent clinical test that is used to evaluate peripheral endothelial function. 16 In a community-based cohort, Hamburg et al 17 reported a significant relationship between RH-PAT and cardiovascular risk factors.…”