Impairment of the Immune Response to Influenza Vaccination in Renal Transplant Recipients by Cyclosporine, but Not Azathioprine

Versluis, Dennis; Beyer, Walter; Masurel, N.; Wenting, G J; Weimar, Willem

doi:10.1097/00007890-198610000-00009

Cited by 121 publications

(80 citation statements)

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“…66 However, others have found an impaired immune response to influenza virus vaccine in recipients of solid-organ transplants, 64 including heart 68 and kidney. 69,70 Immunosuppression regimens appear to be an important variable explaining the divergence of vaccine efficacy. 105 Recipients of heart transplants administered cyclosporine-based immunosuppression responded well to pneumococcal vaccination but had a significantly reduced immune response to influenza vaccine.…”

Section: Vaccinationmentioning

confidence: 99%

“…105 Recipients of heart transplants administered cyclosporine-based immunosuppression responded well to pneumococcal vaccination but had a significantly reduced immune response to influenza vaccine. 71 The use of mycophenolate mofetil 72 and cyclosporine 69 was associated with decreased antibody titer toward influenza vaccine in renal transplant recipients. Conversely, corticosteroids did not affect the responsiveness to the vaccine in a different patient population.…”

Section: Vaccinationmentioning

confidence: 99%

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Influenza Infection in Patients Before and After Liver Transplantation

Duchini¹

2000

Liver Transplantation

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Infection with influenza virus poses specific problems in pediatric and adult liver transplant recipients, both before and after liver transplantation. These include a higher rate of pulmonary and extrapulmonary complications, development of rejection with graft dysfunction, prolonged shedding of influenza virus, and increased drug-resistance. Hepatic decompensation may occur during influenza infection in patients with cirrhosis. Current prophylaxis includes yearly vaccination with trivalent inactivated vaccine. Appropriate diagnosis and prompt treatment of any upper respiratory infections are indicated in these patients. In this review, we describe a case of influenza viral pneumonia in an adult liver transplant recipient, review basic and clinical aspects of influenza infection in this patient population, and discuss current modes of prevention and treatment in detail. (Liver Transpl 2000;6: 531-542.)

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Section: Vaccinationmentioning

confidence: 99%

Section: Vaccinationmentioning

confidence: 99%

Influenza Infection in Patients Before and After Liver Transplantation

Duchini¹

2000

Liver Transplantation

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“…Therefore, a booster immunisation after at least 4 weeks seems to be advisable in patients with diabetes mellitus. However, results of booster vaccination in other risk groups are disappointing [10,22].…”

Section: Controlmentioning

confidence: 99%

“…Poor antibody response to influenza vaccination has been demonstrated in various risk groups, such as renal transplant patients [10], patients with malignant diseases [11,12] and in the aged [13].…”

mentioning

confidence: 99%

Humoral immune response and delayed type hypersensitivity to influenza vaccine in patients with diabetes mellitus

Diepersloot

Bouter

Beyer³

et al. 1987

Diabetologia

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Summary.The antibody response and delayed type hypersensitivity reaction to commercially available trivalent influenza vaccine in 159 patients with diabetes mellitus was compared with response and reaction in 28 healthy volunteers. A correction for prevaccination titres was made. No differences were found between diabetic patients and control subjects with respect to antibody response to the three vaccine strains as measured by the difference between geometric mean titres of post-and prevaccination sera. In Type 1 (insulin-dependent) diabetic patients the incidence of non-responders to two vaccine components was significantly increased (p< 0.05). The delayed type hypersensitivity reaction to influenza antigen was significantly decreased in patients with high concentrations of glycosylated haemoglobin (p<0.01). These findings suggest a role for impaired immune response in the increased influenza morbidity and mortality in patients with diabetes mellitus. Implications for therapy and vaccination strategy are discussed.

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“…In hemodialysis patients, uraemic toxins, blood transfusions, iron overload, dialysis membranes and biological incompatibility can adversely affect the immune response. 15 In RTRs, the immune response can be decreased in all patients, 16 or only in patients receiving cyclosporine 17 or mycophenolate mofetil therapy. 18,19 However, the immune response to influenza vaccination has been described as adequate, 20,21 whereas the sero-response to hepatitis B or pneumococcal vaccination after transplantation and dialysis appears to be poor.…”

mentioning

confidence: 99%