Impairment of sociocognitive functions in patients with brain tumours

Genome-wide association study detected novel susceptibility genes for social cognition impairment in people with schizophrenia

“…The study was conducted in two cohorts including 253 and 184 SCZ patients, respectively, who were part of a larger multicenter study, involving Italian patients with SCZ recruited throughout the national territory (Galderisi et al 2014). According to that study, patients were enrolled if they met the following inclusion criteria: Exclusion criteria a, b and c were chosen to avoid the confounding effect of other conditions that may impact SC, such as head trauma (McDonald 2013), neurological diseases (Pertz et al 2020) and alcohol and/or substance abuse (Homer et al 2008;Le Berre 2019). The remaining two exclusion criteria (current pregnancy or lactation and inability to provide an informed consent) were chosen for ethical reasons.…”

Cognitive and affective Theory of Mind double dissociation after parietal and temporal lobe tumors

“…Future studies would be critical to replicate these findings also with other ToM tasks. Furthermore, although the SET task is a clinically validated tool to detect ToM deficits with respect to the healthy population, what still needs to be assessed is to what extent ToM deficits are correlated to real-life everyday dysfunctional behaviours and on this aspect the neuropsychological literature on ToM is still largely insufficient 80 . Further research is thus needed on this regard.…”

“…Finally, this study benefited from a large sample of brain tumor patients, which allow for a widespread coverage of a large portion of the brain (see Supplementary Figure 1), including both lateral and medial structures, highly relevant for the investigation of ToM deficits. However, the heterogeneity of the tumour types and the effects of surgery might act as confounds, as suggested in recent review of ToM studies 80 . Brain reorganization is particularly pronounced in patients with…”

The neural underpinnings of facial emotion recognition in ischemic stroke patients

“…These structures roughly involve the orbitofrontal and occipito‐temporal circuits. Not surprisingly, impairments in emotion recognition have been found in a number of patient groups with damage to these brain structures, including patients with stroke (Nijsse et al., 2019; van den Berg, Huitema, Spikman, Luijckx, & de Haan, 2020; Yuvaraj et al., 2013), but also patients with brain tumours (Pertz, Okoniewski, Schlegel, & Thoma, 2020), Traumatic Brain Injury (TBI; Babbage et al., 2011; Spikman et al., 2013; Young, Newcombe, De Haan, Small, & Hay, 1993), subarachnoid haemorrhage (Buunk et al., 2017) and patients with neurodegenerative diseases (NDD), such as Alzheimer’s Disease, Parkinson’s Disease and Fronto‐temporal dementia (Christidi, Migliaccio, Santamaría‐García, Santangelo, & Trojsi, 2018).…”