Impairment of single-trial memory formation by oral methylphenidate in the rat

Chuhan, Yadvinder S; Taukulis, Harald K.

doi:10.1016/j.nlm.2005.09.001

Cited by 37 publications

(24 citation statements)

References 30 publications

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“…Because novelty exploration is also considered to be a rewarding stimulus, the memory enhancing effects of dimebon in the new object exploration/localization paradigms mentioned above and described by other groups (Chuhan and Taukulis, 2006;Giorgetti et al, 2010) indirectly support our findings.…”

Section: Discussionsupporting

confidence: 88%

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

Vignisse

Steinbusch

Bolkunov

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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a b s t r a c t a r t i c l e i n f oPre-clinical and clinical studies on dimebon (dimebolin or latrepirdine) have demonstrated its use as a cognitive enhancer. Here, we show that dimebon administered to 3-month-old C57BL6N mice 15 min prior to training in both appetitive and inhibitory learning tasks via repeated (0.1 mg/kg) and acute (0.5 mg/kg) i.p. injections, respectively, increases memory scores. Acute treatment with dimebon was found to enhance inhibitory learning, as also shown in the step-down avoidance paradigm in 7-month-old mice. Bolus administration of dimebon did not affect the animals' locomotion, exploration or anxiety-like behaviour, with the exception of exploratory behaviour in older mice in the novel cage test. In a model of appetitive learning, a spatial version of the Y-maze, dimebon increased the rate of correct choices and decreased the latency of accessing a water reward after water deprivation, and increased the duration of drinking behaviour during training/testing procedures. Repeated treatment with dimebon did not alter the behaviours in other tests or water consumption. Acute treatment of water-deprived and non-water-deprived mice with dimebon also did not affect their water intake. Our data suggest that dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory tasks in mice.

show abstract

Section: Discussionsupporting

confidence: 88%

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

Vignisse

Steinbusch

Bolkunov

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Animal models are critical to this understanding; frequently however, the methods used to administer drugs are distinct from human administration and therefore may limit applicability (Chuhan and Taukulis, 2006;Segal, 2002, 2005). Route of administration has profound effects on the physiological response to a drug, yet is often overlooked.…”

Section: Introductionmentioning

confidence: 99%

“…Less invasive methods of MPH oral administration in rodents include ingestion of wet mash (Chuhan and Taukulis, 2006;LeBlanc-Duchin and Taukulis, 2004), crackers moistened with MPH solution (Arnsten and Dudley, 2005) and spiked drinking water (Ding et al, 2004), yet these methods must be consumed voluntarily and cannot be used in the neonate. It is arguably more important to use an oral method at an early age, as the developing brain has been shown to be more sensitive to pharmacological and environmental impact (Adriani and Laviola, 2004;Andersen, 2005;Mirescu et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

A novel method for oral stimulant administration in the neonate rat and similar species

Wheeler

Eppolito

Smith

et al. 2007

Journal of Neuroscience Methods

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“…One study showed that especially dopamine type-1 receptor agonists can improve object memory (de Lima et al 2011). Interestingly, acute methylphenidate treatment impaired object recognition performance in healthy animals (Chuhan and Taukulis 2006). Also for serotonergic drugs, many studies examined the effects in deficit models.…”

Section: Prediction Of Results By Preclinical Studiesmentioning

confidence: 99%

Declarative Memory

Riedel

Blokland

2015

Handbook of Experimental Pharmacology

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Declarative Memory consists of memory for events (episodic memory) and facts (semantic memory). Methods to test declarative memory are key in investigating effects of potential cognition-enhancing substances--medicinal drugs or nutrients. A number of cognitive performance tests assessing declarative episodic memory tapping verbal learning, logical memory, pattern recognition memory, and paired associates learning are described. These tests have been used as outcome variables in 34 studies in humans that have been described in the literature in the past 10 years. Also, the use of episodic tests in animal research is discussed also in relation to the drug effects in these tasks. The results show that nutritional supplementation of polyunsaturated fatty acids has been investigated most abundantly and, in a number of cases, but not all, show indications of positive effects on declarative memory, more so in elderly than in young subjects. Studies investigating effects of registered anti-Alzheimer drugs, cholinesterase inhibitors in mild cognitive impairment, show positive and negative effects on declarative memory. Studies mainly carried out in healthy volunteers investigating the effects of acute dopamine stimulation indicate enhanced memory consolidation as manifested specifically by better delayed recall, especially at time points long after learning and more so when drug is administered after learning and if word lists are longer. The animal studies reveal a different picture with respect to the effects of different drugs on memory performance. This suggests that at least for episodic memory tasks, the translational value is rather poor. For the human studies, detailed parameters of the compositions of word lists for declarative memory tests are discussed and it is concluded that tailored adaptations of tests to fit the hypothesis under study, rather than "off-the-shelf" use of existing tests, are recommended.

show abstract

Impairment of single-trial memory formation by oral methylphenidate in the rat

Cited by 37 publications

References 30 publications

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

A novel method for oral stimulant administration in the neonate rat and similar species

Declarative Memory

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