Impairment of renal urinary excretion in neonatal, but not in adult capsaicin-pretreated rats

Manzini, Stefano; Bacciarelli, C; Perfumi, Marina; Massi, Maurizio

doi:10.1016/0304-3940(92)90122-n

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…in our animals, but to our knowledge these issues are not addressed in the current literature. However, Manzini et al (1992) reported that capsaicin treatment had no effect on renal urinary function in adult rats while it induced a reduction in volume of urine and electrolyte excretions in neonatal treated rats.…”

Section: Resultsmentioning

confidence: 98%

Effects of capsaicin-induced sensory denervation on osteoclastic resorption in adult rats

Adam¹,

Llorens²,

Baroukh³

et al. 2000

Exp. Physiol.

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Section: Resultsmentioning

confidence: 98%

Effects of capsaicin-induced sensory denervation on osteoclastic resorption in adult rats

Adam¹,

Llorens²,

Baroukh³

et al. 2000

Exp. Physiol.

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“…Previous studies indicated that neonatal capsaicin administration to normal rat pups results in an antinatriuretic and antidiuretic effect in adult life. [30][31][32] The mechanism underlying this possible renal inhibitory effect of capsaicin remains unclear. However, acute capsaicin dosing appears to have no effect on renal function, [30][31][32] so the effect of neonatal treatment is likely mediated through primary afferent denervation.…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32] The mechanism underlying this possible renal inhibitory effect of capsaicin remains unclear. However, acute capsaicin dosing appears to have no effect on renal function, [30][31][32] so the effect of neonatal treatment is likely mediated through primary afferent denervation. In any case, we did not observe any renal or haemodynamic effect of capsaicin in our sham operated control rats, and the effects on renal function in our BDL rats were opposite to the effects described in normal rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of neonatal capsaicin treatment on haemodynamics and renal function in cirrhotic rats

2003

Gut

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Background: Mechanisms underlying abnormalities of circulation and renal function in cirrhosis are not completely understood. Our previous study revealed that primary afferent denervation by neonatal capsaicin treatment prevented the development of hyperdynamic circulation in portal hypertensive and cirrhotic rats. Aims: The present study aimed to clarify the role of capsaicin sensitive nerves in the development of renal dysfunction and ascites formation in cirrhosis. Methods: Rat pups were injected with capsaicin (50 mg/kg) or vehicle and allowed to grow. When they reached adulthood, cirrhosis was induced by bile duct ligation while controls received sham operation. Cardiac output and regional blood flows were measured by radioactive microspheres, glomerular filtration rate by

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“…62032 Camerino, Italy (fax (737) 630618). duction in the response to noxious thermal, mechanical and chemical stimuli (Hayes & Tyers 1980;Gamse 1982), impairment of renal excretion (Manzini et al 1992), depletion of substance P in dorsal ganglia root (Gamse eta/. 1980;Jancso et al 1981;Cervero & Plenderleith 1987) and a wide variety of other effects (Buck & Burks 1986;Holzer 1991).…”

mentioning

confidence: 99%

“…In one month-old rats prenatally treated with capsaicin the response to thermal (hot plate test) and chemical (wiping test) noxious stimulation and the urinary excretion in response to oral water load was evaluated. These tests are normally affected by neonatal but not by adult capsaicin treatment, as a result of its selective degeneration of primary afferent neurones and depletion of substance P and other neurotransmitters (Jancso et al 1977;Hayes & Tyers 1980;Gamse 1982;Rodriguez-Sierra et d. 1988;Manzini et al 1992). …”

mentioning

confidence: 99%

Rat Offspring Treated Prenatally with Capsaicin Do Not Show Some of the Irreversible Effects Induced by Neonatal Treatment with Neurotoxin

Perfumi

Sparapassi

1999

Pharmacology & Toxicology

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Abstrrrc!: The present study evaluates whether some of the irreversible effects induced by neonatally administered capsaicin are present in offspring prenatally treated with the neurotoxin as well, and investigated its foetal toxicity. Capsaicin was administered subcutaneously at doses of 50, 100 and 200 mg/kg in five injections every other day between gestational days 7-15. the period of major organogenesis, or in a single subcutaneous injection of 50 mgikg only at day 15 of gestation. In one-month old rats prenatally capsaicin-treated the response to noxious stimulation (hot plate and wiping tests) and the urinary excretion in response to oral water load were evaluated. Parallel experiments were conducted in one-month old rats treated with capsaicin (SO mgikg) on the 2nd day of life. Prenatal capsaicin induced no evident treatment-related signs of toxicity in dams and offspring, nor did it influence the body growth of the pups or induce cutaneous lesions. Unlike neonatal treatment, prenatal administration of neurotoxin did not raise the threshold to thermal and chemical pain, and did not modify diuresis induced by oral load. Since researchers have proposed the existence of more than one population of capsaicin-sensitive afferent neurones which differ in their age-dependent sensitivity to capsaicin, we hypothesized that failure of prenatal treatment might be due either to reduced foetal availability, not capable of selectively destroying capsaicin-sensitive neurones, or to incomplete rearrangement and maturation of developing primary sensory neurons, in fact, the existence is well known of more than one population of capsaicin-sensitive afferent neurons which differ in their age-dependent sensitivity to capsaicin. Future studies are needed to elucidate the effects of capsaicin at cellular and molecular levels.Capsaicin is a potent neurotoxin which acts on a specific population of sensory neurones which contain neuropeptides

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Impairment of renal urinary excretion in neonatal, but not in adult capsaicin-pretreated rats

Cited by 8 publications

References 14 publications

Effects of capsaicin-induced sensory denervation on osteoclastic resorption in adult rats

Effects of capsaicin-induced sensory denervation on osteoclastic resorption in adult rats

Effect of neonatal capsaicin treatment on haemodynamics and renal function in cirrhotic rats

Rat Offspring Treated Prenatally with Capsaicin Do Not Show Some of the Irreversible Effects Induced by Neonatal Treatment with Neurotoxin

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