Impairment of Primary Hemostasis and Platelet Function after Alcohol Ingestion in Man

Elmér, Olle; Göransson, Göran; Zoucas, Evita

doi:10.1159/000215060

Cited by 45 publications

(32 citation statements)

References 23 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, impaired platelet function, altered liver functions and deranged coagulation parameters add to the existing maladies. 7 Our findings are in tune with above studies. In our study all the 4 patients with poor outcome [2 deaths] were males.…”

Section: Discussion: Analysis Of Resultssupporting

confidence: 92%

Role of Repeat Ct Scan in Detecting Delayed Intracranial Bleed

Nayak¹,

Kumar²

2015

jemds

View full text Add to dashboard Cite

Section: Discussion: Analysis Of Resultssupporting

confidence: 92%

Role of Repeat Ct Scan in Detecting Delayed Intracranial Bleed

Nayak¹,

Kumar²

2015

jemds

View full text Add to dashboard Cite

“…16 Crossover trials of alcohol administration have variously reported dose-dependent decreases 14,28 or no change 29 in TPA activity. Most 12,16,24 but not all 15 studies indicate that alcohol increases TPA antigen concentrations, consistent with lower TPA activity.…”

Section: Previous Studies Of Alcohol and Hemostatic Factorsmentioning

confidence: 99%

“…7,9,11 Previous studies of the relation between alcohol consumption and hemostatic function have also been limited by small sample size, restriction to men, failure to distinguish between beverage types, and measurement of few hemostatic parameters. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] We therefore studied the relation between alcohol consumption and hemostatic function in 3223 adults enrolled in the Framingham Offspring Study, a prospective study of cardiovascular disease among the children of the original Framingham Heart Study subjects. 31 We studied both women and men, examined a broad range of coagulatory and fibrinolytic parameters, and considered the effects of individual beverage type.…”

mentioning

confidence: 99%

Alcohol Consumption and Hemostatic Factors

et al. 2001

View full text Add to dashboard Cite

Background-Moderate alcohol consumers have lower rates of cardiovascular disease than abstainers. One proposed mechanism is a beneficial effect on hemostatic parameters, but previous studies have provided conflicting results. Methods and Results-We measured levels of fibrinogen, plasma viscosity, von Willebrand factor, factor VII, plasminogen activator inhibitor antigen-1, and tissue plasminogen activator antigen in a cross-sectional analysis of 3223 adults free of cardiovascular disease enrolled in the Framingham Offspring Study. We assessed their alcohol consumption with a standardized questionnaire. Light-to-moderate alcohol consumption was associated with lower levels of fibrinogen, plasma viscosity, von Willebrand factor, and factor VII. This association was most pronounced for consumers of 3 to 7 drinks weekly for viscosity and 7 to 21 drinks weekly for the other hemostatic measures. Alcohol intake of 7 to 21 drinks weekly or more was associated with impaired fibrinolytic potential, reflected by higher levels of plasminogen activator inhibitor antigen-1 and tissue plasminogen activator antigen. Wine drinkers had lower plasminogen activator inhibitor antigen-1 levels than other drinkers, particularly at 3 to 21 drinks weekly, but beverage type did not otherwise consistently affect the results. Conclusions-Light-to-moderate alcohol consumption is associated with lower levels of coagulatory factors, but higher intake is associated with impaired fibrinolytic potential. These findings are consistent with the hypothesis that a balance between hemostatic and fibrinolytic activity may contribute to the complex relation of alcohol use with coronary heart disease.

show abstract

“…However, these studies have in general been performed on components of blood, rather than on whole blood, and the effects reported are not in agreement. Several studies have found an alcohol induced impairment of the primary hemostasis, whereas the humoral coagulation factors and the fibrinolytic system were unaffected [7][8][9]. El-Sayed et al [10] corroborated these results on the humoral coagulation factors and the fibrinolysis, but others have found an acute impairment of the fibrinolytic system by increased ethanol levels [11,12].…”

Section: Introductionmentioning

confidence: 98%

Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry

Engström

Schött

Reinstrup

2006

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

Objective: The objective of the study was to study the effects of ethanol on the coagulation and the fibrinolysis in whole blood. Methods: Blood samples from healthy volunteers were analysed before and after in vitro addition of ethanol in order to achieve ethanol concentrations of 0‰, 1‰, 2‰ and 4‰ respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. Results: We found that increasing ethanol levels increasingly impaired coagulation as evaluated with rotational thromboelastometry with a maximum prolongation of Clot Formation Time of 118% at an ethanol level of 4‰ (p<0.000001). We also found a very strong impairment of fibrinolysis already at an ethanol level of 1‰. Conclusions: This is the first study assessing the effects of ethanol on coagulation and fibrinolysis in a whole blood model. The impairment of coagulation is similar in nature to the impairment found in patients suffering from hypothermia. The impairment is at a level that may be of clinical importance, e.g. in patients suffering from trauma. The inhibition of fibrinolysis is obvious already at an ethanol level of 1‰ and it may be a contributing factor to the increased amount of coronary and cerebrovascular ischemic events after binge drinking.

show abstract

Impairment of Primary Hemostasis and Platelet Function after Alcohol Ingestion in Man

Cited by 45 publications

References 23 publications

Role of Repeat Ct Scan in Detecting Delayed Intracranial Bleed

Role of Repeat Ct Scan in Detecting Delayed Intracranial Bleed

Alcohol Consumption and Hemostatic Factors

Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry

Contact Info

Product

Resources

About