Impairment of nasal mucociliary clearance after radiotherapy for childhood head cancer

Surico, Giammarco; Muggeo, Paola; Mappa, Luigi; Muggeo, Vito M. R.; Conti, Valeria; Lucarelli, Annunziata; Novielli, Chiara; Rigillo, N

doi:10.1002/hed.1060

Cited by 31 publications

(27 citation statements)

References 16 publications

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“…Higher radiation doses have been proven to cause a statistically significant slower nasal mucociliary clearance in children by Surico et al 30 However, there was no significant difference in Lund scores between two radiation dose groups (RT doses ≦7,020 cGy and RT doses >7,020 cGy) in our study. In our patients, the radiation dose (6,400–7,600 cGy) was higher than in Surico et al's series (1,800–5,400 cGy).…”

Section: Discussioncontrasting

confidence: 83%

Postirradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients

Huang

Lee

et al. 2007

The Laryngoscope

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Section: Discussioncontrasting

confidence: 83%

Postirradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients

Huang

Lee

et al. 2007

The Laryngoscope

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“…Similar histological findings of epithelial change and ciliary loss have been observed in irradiated larynx and nasopharynx tissue from humans 47,48 . Functional studies of cilia by measuring nasal secretion transport times have shown significantly slower transport in irradiated adults and children compared to healthy controls 49,50 . Many patients who have been treated with radiation go on to develop chronic sinusitis 47,51 …”

Section: Introductionmentioning

confidence: 59%

Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era

et al. 2020

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Background: Pulmonary complications and infections frequently affect patients with head and neck squamous cell carcinoma (HNSCC). Common characteristics can predispose these patients to the development of severe respiratory illness, which may be particularly relevant during the 2019 coronavirus disease (COVID-19) pandemic. Methods: A scoping review was performed to assess the impact of pulmonary comorbidities and adverse respiratory outcomes in HNSCC patients. Results: Advanced age, history of tobacco and alcohol abuse, and cardiopulmonary comorbidities are significant risk factors for the development of adverse respiratory outcomes. Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks.Conclusion: Respiratory complications are a frequent cause of morbidity and mortality among HNSCC patients, and the COVID-19 pandemic may disproportionately affect this population. Interventions designed to decrease smoking and alcohol use, improve oral hygiene, and aggressively manage medical comorbidities are important to the long-term management and health of these patients. K E Y W O R D Sadverse respiratory outcomes, COVID-19, head and neck squamous cell carcinoma (HNSCC), pulmonary comorbidities, respiratory infections and complications

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“…Impairment of central or peripheral pathways for the transmission of olfactory stimuli due to radiotherapy has been demonstrated in previous studies 28 . Patients who have been treated with radiotherapy have a prolonged mucociliary clearance that leads to an increase in the frequency of upper respiratory tract infections and also to an increase in smell disorders 29 .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of smell disorders after radiotherapy in patients with laryngeal neoplasm

Műhlfay

Neagos

et al. 2020

Romanian Journal of Rhinology

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BACKGROUND. Smell disorders may be classified in quantitative and qualitative. The literature shows that the main causes of odour disorders, both qualitative and quantitative, are due to aging, viral infections and tumors of the upper respiratory tract, craniocerebral trauma, neurodegenerative diseases of the nervous system, drug use or exposure to various toxic substances. Total laryngectomy and oncologic treatment causes smell disorders.OBJECTIVE. The aim of this study is to evaluate the aspects related to the patient’s smell disorders after total laryngectomy, during the oncological treatment represented by radiotherapy.MATERIAL AND METHODS. A prospective observational study was performed on a group of 52 patients, over a period of one year (2016-2017), who benefited from total laryngectomy and who underwent oncological treatment, represented by radiotherapy. Patients were evaluated before starting radiotherapy and during radiotherapy sessions. All patients underwent quantitative and qualitative smell assessment.RESULTS. At the end of week 7 of radiotherapy, none of the patients was considered normosmic, 10 patients were considered to be suffering from hyposmia and 42 from anosmia. Statistically significant changes in the quantitative determination of odour occurred in the fourth week, respectively at the radiation dose of 40Gy. Qualitative odour assessment in this study showed a statistically significant decrease starting with the fifth week of radiotherapy, respectively with a radiation dose of 50Gy.CONCLUSION. Radiation therapy has a major impact on the quality of life of patients with laryngeal cancer, which has the lowest scores at the beginning and end of the treatment.

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Impairment of nasal mucociliary clearance after radiotherapy for childhood head cancer

Cited by 31 publications

References 16 publications

Postirradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients

Postirradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients

Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era

Evaluation of smell disorders after radiotherapy in patients with laryngeal neoplasm

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