Impairment of memory for spatial context in schizophrenia.

Rizzo, Lydia; Danion, Jean-Marie; Linden, Martial Van der; Grangé, Danielle; Rohmer, Jean-Georges

doi:10.1037/0894-4105.10.3.376

Cited by 73 publications

(52 citation statements)

References 66 publications

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“…The task was comparable to that of Rizzo et al (1996) with two exceptions. Firstly, binding was intentional, not incidental (i.e.…”

Section: Introductionmentioning

confidence: 68%

“…determining if information was self-generated or provided by the experimenter) (Bentall et al, 1991;Rankin and O'Carroll, 1995). Such findings raise the possibility that episodic memory deficits in patients with schizophrenia may be related to a failure of binding features together to create more complex representations (Rizzo et al, 1996;Danion et al, 1999). Most studies, however, do not separately assess memory for individual features and memory for bound features.…”

Section: Introductionmentioning

confidence: 87%

“…However, because there is consistent evidence that patients with schizophrenia fail to organize and elaborate ongoing experience, Rizzo et al (1996) proposed that the origin of the binding deficit may be at the early stage of encoding that comprises the critical processes for establishing associations between the different features of events, that is, in working memory.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies, however, do not separately assess memory for individual features and memory for bound features. An exception is a study by Rizzo et al (1996). They presented schizophrenic patients and healthy controls with a grid in which 30 words were displayed successively.…”

Section: Introductionmentioning

confidence: 99%

“…Schizophrenia is associated with episodic memory deficits (for reviews, see Heinrichs and Zakzanis, 1998;Aleman et al, 1999). For example, patients with schizophrenia exhibit impairments of memory for temporal information (Schwartz et al, 1991;Rizzo et al, 1996), frequency of occurrence of events (Gras-Vincendon et al, 1994), and reality monitoring (i.e. determining if information was self-generated or provided by the experimenter) (Bentall et al, 1991;Rankin and O'Carroll, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Impaired performance in a working memory binding task in patients with schizophrenia

Burglen

Marczewski

Mitchell

et al. 2004

Psychiatry Research

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This study investigated feature binding in a working memory task in patients with schizophrenia and in normal controls. Twenty-five patients and 25 controls participated. On each trial, three drawings of familiar objects were presented sequentially, each in a different cell of a 3=3 grid. In different blocks of trials, participants remembered either individual features (object and location conditions) or an object and its location (combination condition). The results showed that patients were slower and less accurate than controls under all conditions. Accuracy of both groups was reduced in the combination condition relative to the single-feature conditions, but patients showed disproportionately poorer performance in the combination condition than in the object and location conditions. Thus, patients with schizophrenia exhibit deficits in working memory, particularly when the task requires binding objects to their locations. This finding demonstrates that processes that establish coherent and temporary episodic representations in working memory are impaired in schizophrenia. ᮊ

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“…The task was comparable to that of Rizzo et al (1996) with two exceptions. Firstly, binding was intentional, not incidental (i.e.…”

Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impaired performance in a working memory binding task in patients with schizophrenia

Burglen

Marczewski

Mitchell

et al. 2004

Psychiatry Research

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Functional Mechanisms Underlying Impaired Recognition Memory and Conscious Awareness in Patients With Schizophrenia

Danion¹,

Rizzo²,

Bruant³

1999

Arch Gen Psychiatry

286

150

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Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Achim

Bertrand²,

Sutton³

et al. 2007

Arch Gen Psychiatry

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Context: Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others.Objective: To examine the neural correlates of 3 specific memory processes in FEP by means of functional magnetic resonance imaging (fMRI).Design: Case-control study. Main Outcome Measures:Behavioral performance and regional brain activity measured during memory encoding by fMRI. Our fMRI design included 3 within-subject contrasts (associative vs item-oriented encoding, encoding of arbitrary vs semantically related image pairs, and successful vs unsuccessful memory encoding) that were then used for group conjunctions and between-group analyses.Results: Patients with FEP showed normal activation of several brain regions, including the prefrontal cortex, hippocampus, and parahippocampal cortex, during successful memory encoding and associative encoding. In contrast, the hippocampus and surrounding medial temporal areas showed reduced activity during the encoding of arbitrary pairs. This selective dysfunction reflected by abnormal brain activation during encoding was accompanied by a greater deficit for subsequent recognition of arbitrary pairs relative to the semantically related pairs.Conclusions: This study demonstrated that, in the same group of patients with FEP, the hippocampus could show either normal or abnormal modulation of activation depending on the specific cognitive process that was examined. The normal modulation of hippocampal activation observed during successful memory encoding in FEP argues against a general inability to recruit this region. Instead, the dysfunction was specifically linked to semantic relatedness. This selective deficit seems to affect memory performance in FEP and denotes an important representational problem that may confer greater vulnerability to psychotic disorders and would thus be interesting to examine in high-risk populations. Psychiatry. 2007;64(9):999-1014 Arch Gen

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Impairment of memory for spatial context in schizophrenia.

Cited by 73 publications

References 66 publications

Impaired performance in a working memory binding task in patients with schizophrenia

Impaired performance in a working memory binding task in patients with schizophrenia

Functional Mechanisms Underlying Impaired Recognition Memory and Conscious Awareness in Patients With Schizophrenia

Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

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