Impairment of mating behavior in male rats following lesions in the preoptic-anterior hypothalamic continuum

Heimer, Lennart; Larsson, Knut

doi:10.1016/0006-8993(67)90076-5

Cited by 387 publications

(110 citation statements)

References 13 publications

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“…Everitt [54] has suggested that the ventral striatal system regulates sexual motivation, whereas the MPOA controls mainly copulatory performance and is not important for sexual motivation. This postulation is supported by reports that male rats with MPOA lesions pursued estrous females and investigated their anogenital region similarly to animals with sham lesions [34,55], suggesting that animals with lesions maintain sexual interest. Similar patterns of behavior were observed in cats [56] and dogs [57] with MPOA lesions.…”

Section: Role Of the Mpoa In Regulating Male Sexual Motivationmentioning

confidence: 56%

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Dopamine, the medial preoptic area, and male sexual behavior

Domínguez

Hull

2005

Physiology & Behavior

244

184

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Section: Role Of the Mpoa In Regulating Male Sexual Motivationmentioning

confidence: 56%

“…The severity of sexual impairment by MPOA lesions is dependent on the lesion's size and location. Smaller MPOA lesions have variable and less severe effects than larger lesions [33,34]. Lesions of the caudal MPOA, including the rostral anterior hypothalamus, impaired copulation more severely than did those of the rostral MPOA [35].…”

Section: Ablation Of the Mpoamentioning

confidence: 92%

Dopamine, the medial preoptic area, and male sexual behavior

Domínguez

Hull

2005

Physiology & Behavior

244

184

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“…motivational) and consummatory components (i.e., copulatory behavior) of male sexual behavior. In rats for example, lesions to the mPOA eliminate male-typical copulatory behavior [77,80] but have more discrete or no effects on some measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females [35]; they also perform learned instrumental responses to gain access to females [67,68].…”

Section: The Medial Preoptic Area Is Also Implicated In the Control Omentioning

confidence: 99%

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

189

168

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Several studies have suggested dissociations between neural circuits underlying the expression of appetitive (i.e. sexual motivation) and consummatory components (i.e., copulatory behavior) of vertebrate male sexual behavior. The medial preoptic area (mPOA) clearly controls the expression of male copulation but, according to a number of experiments, is not necessarily implicated in the expression of appetitive sexual behavior. In rats for example, lesions to the mPOA eliminate maletypical copulatory behavior but have more subtle or no obvious effects on measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females. They also acquire and perform learned instrumental responses to gain access to females. However, recent lesions studies and measures of the expression of the immediate early gene c-fos demonstrate that, in quail, subregions of the mPOA, in particular of its sexually dimorphic component the medial preoptic nucleus, can be specifically linked with either the expression of appetitive or consummatory sexual behavior. In particular more rostral regions can be linked to appetitive components while more caudal regions are involved in consummatory behavior. This functional sub-region variation is associated with neurochemical and hodological specializations (i.e. differences in chemical phenotype of the cells or in their connectivity), especially those related to the actions of androgens in relation to the activation of male sexual behavior, that are also present in rodents and other species. It could thus reflect general principles about POA organization and function in the vertebrate brain.

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“…In females, bilateral lesions of the MPO facilitate the occurrence of lordosis (Powers and Valenstein, 1972;Nance et al, 1977;Rodriguez-Sierra and Terasawa, 1979;Lisk and MacGregor, 1982;Hoshina et al, 1994); chemical or electrical stimulation of MPO suppresses it (Moss et al, 1974;Zasorin et al, 1975;Pfaff and Sakuma, 1979;Takeo et al, 1993). By contrast, in males MPO lesions completely abolish mounting, intromission, and ejaculation, whereas stimulation of this region induces copulation (Heimer and Larrson, 1966;Lisk, 1966;Malsbury et al, 1981;Hansen et al, 1982;Arendash and Gorski, 1983;Edwards and Einhorn, 1986).…”

Section: Reproductivementioning

confidence: 99%

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

et al. 1996

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We have shown recently that the medial preoptic area (MPO) robustly innervates discrete columns along the rostrocaudal axis of the midbrain periaqueductal gray (PAG). However, the location of PAG neurons responsive to MPO activation is not known. Anterograde tract tracing was used in combination with Fos immunohistochemistry to characterize the MPO -+ PAG pathway anatomically and ,functionally within the same animal. Focal electrical or chemical stimulation of MPO in anesthetized rats induced extensive Fos expression within the PAG compared with sham controls. Fos-positive neurons were organized as 2-3 longitudinal columns. The organization and location of these columns overlapped remarkably well with the distribution of fibers and terminals in PAG labeled by Phaseolus vulgaris leucoagglutinin (PHA-L) injected into the same MPO stimulation site. This indicates that MPO inputs may terminate on the soma or proximal dendrites of neurons exhibiting elevated Fos. A second series of experiments investigated whether MPO stimulation excited PAG neurons with descending projections to the medulla. Retrograde labeling of PAG neurons projecting to the medial and lateral regions of the rostroventral medulla (RVM) was combined with MPO-induced Fos expression. The results showed that a substantial population (3743%)of Fos-positive PAG neurons projected to the ventral medulla. This indicates that MPO stimulation engages PAG-medullary output neurons. Taken together, these results suggest that the MPO + PAG + RVM projection constitutes a functional pathway. This circuit may coordinately regulate neuroendocrine, motor, and autonomic adjustments necessary for the elaboration of sexual behaviors.Key words: reproduction; antinociception; cardiovascular regulation; brainstem; sexual behavior; immunohistochemistryThe medial preoptic area (h/[PO) is a sexually dimorphic structure Simerly et al., 1984;Bloch and Gorski, 1988) that plays a pivotal role in sexual behavior and neuroendocrine function (Lisk, 1966;Powers and Valenstein, 1972;Pfaff and Sakuma, 1979;Hansen et al., 1982;Arendash and Gorski, 1983;Kalra and Kalra, 1983;Docke et al., 1984;Sachs and Meisel, 1988;Simerly et al., 1990;DonCarlos et al., 1991;Takeo et al., 1993;Hoshina et al., 1994). We recently reported that MPO robustly innervates the midbrain periaqueductal gray (PAG) (Rizvi et al., 1992) and terminates in discrete, longitudinally organized columns running through the rostrocaudal axis of PAG.PAG plays a key role in antinociception (Reynolds, 1969;Liebeskind et al., 1973;Oliveras et al., 1974;Behbehani and Fields, 1979; Lovick, 3985;Morgan and Liebeskind, 1987;Reichling et al., 1988;Lovick, 1990), cardiovascular control (Lovick, 1985;Carrive et al., 1987;Carrive et al., 1988;Carrive et al., 1989a;Lovick, 1990;Verberne and Guyenet, 1992;Murphy et al., 1994a;Murphy et al., 1995), and many of the same neuroendocrine and reproductive functions as MPO (Pfaff and SchwartzGiblin, 1988;Ogawa et al., 1991;Shipley et al., 1995). PAG neurons involved in these functions also are ...

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Impairment of mating behavior in male rats following lesions in the preoptic-anterior hypothalamic continuum

Cited by 387 publications

References 13 publications

Dopamine, the medial preoptic area, and male sexual behavior

Dopamine, the medial preoptic area, and male sexual behavior

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

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