Impairment of male copulatory behavior in rhesus monkeys following acute administration of cocaine

Nitric oxide as a mediator of cocaine‐induced penile erection in the rat

“…Our demonstration of prolonged increase in ICP by direct application of cocaine to the corpus cavernosum of rodents was in agreement with previous clinical reports that associate priapism with intraurethral (Mahler et al, 1988) or topical (Rodriguez-Blazquez et al, 1990) administration of cocaine. Our observations, however, are at variance with a recent demonstration (Pomerantz et al, 1994) of an impairment of male copulatory behaviour in rhesus monkeys following acute intramuscular administration of cocaine. Such a discrepancy may be due to the difference in species of animal used, route of administration and dose of cocaine.…”

“…Cocaine also facilitates the release of dopamine from reserpine-sensitive storage pools (Heikkila et al, 1975) and stimulates tyrosine hydroxylase activity (Taylor & Ho, 1978;Akbari & Azmitia, 1992). By inhibiting the re-uptake of noradrenaline at the neuroeffector junction, the major peripheral effect of cocaine appears to be sympathomimetic (Van Dyke & Byck, 1982;Jain et al, 1990;Tella et al, 1990;Schindler et al, 1992 It is possible that stimulation of dopamine receptors by cocaine may be more discrete than that accomplished through direct dopamine administration (Pomerantz et al, 1994). Since cocaine augments stimulation of dopamine receptors by blocking the re-uptake of the biogenic amine, it exerts its action only in those regions that are actively releasing dopamine.…”

“…It is possible that stimulation of dopamine receptors by cocaine may be more discrete than that accomplished through direct dopamine administration (Pomerantz et al, 1994). Since cocaine augments stimulation of dopamine receptors by blocking the re-uptake of the biogenic amine, it exerts its action only in those regions that are actively releasing dopamine.…”

The Neurobiology of Sexual Function

“…224 After long-term (eg, 5 days) cocaine administration, cocaine no longer facilitated erection even after 1 week after termination of the drug. 223,224 Short-term cocaine administration in nonhuman primates produced a dose-dependent delay in initiation of copulation and ejaculation 225,226 and did not produce an increase in sexual activity. 226 These effects were reversed by the D 2 antagonist, haloperidol.…”