Impairment of lipid storage by cadmium in the European eel (Anguilla anguilla)

Pierron, Fabien; Baudrimont, Magalie; Bossy, Angélique; Bourdineaud, Jean‐Paul; Brèthes, Daniel; Élie, Pierre; Massabuau, Jean‐Charles

doi:10.1016/j.aquatox.2006.12.014

Cited by 115 publications

(67 citation statements)

References 37 publications

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“…This enzyme notably presents a high affinity for apoE-rich lipoproteins and b-VLDL (Taira et al 2011). Such an increase could appear in accordance with previous results obtained by Pierron et al 2007 who reported a significant increase in lipolysis and energy needs in the liver of eels experimentally exposed to dissolved Cd at 5 lg L -1 during 30 days. Finally, two genes encoding enzymes involved in ubiquitin conjugation pathway were also affected by Cd contamination.…”

Section: Cadmiumsupporting

confidence: 81%

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

et al. 2014

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Identifying specific effects of contaminants in a multi-stress field context remain a challenge in ecotoxicology. In this context, ''omics'' technologies, by allowing the simultaneous measurement of numerous biological endpoints, could help unravel the in situ toxicity of contaminants. In this study, wild Atlantic eels were sampled in 8 sites presenting a broad contamination gradient in France and Canada. The global hepatic transcriptome of animals was determined by RNA-Seq. In parallel, the contamination level of fish to 8 metals and 25 organic pollutants was determined. Factor analysis for multiple testing was used to identify genes that are most likely to be related to a single factor. Among the variables analyzed, arsenic (As), cadmium (Cd), lindane (c-HCH) and the hepato-somatic index (HSI) were found to be the main factors affecting eel's transcriptome. Genes associated with As exposure were involved in the mechanisms that have been described during As vasculotoxicity in mammals. Genes correlated with Cd were involved in cell cycle and energy metabolism. For c-HCH, genes were involved in lipolysis and cell growth. Genes associated with HSI were involved in protein, lipid and iron metabolisms. Our study proposes specific gene signatures of pollutants and their impacts in fish exposed to multi-stress conditions.

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Section: Cadmiumsupporting

confidence: 81%

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

et al. 2014

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“…This toxic metal is known to have various adverse effects on organisms, such as lesions in the kidney or intestinal tissues, induction of reactive oxygen species, DNA damage, impact on hepatic enzymes activities and lipid peroxidation (Mayack et al 1981;Jordan et al 1990;Wang et al 2004;Erdogan et al 2005;Berzina et al 2007). Moreover, Cd impairment on lipid metabolism has also been demonstrated on fish and mammalian species (Pierron et al 2007;Larregle et al 2008). This effect observed in European eels was mainly explained by an increased utilisation of triglycerides for the renewal of damaged lipid or to provide energy under Cd exposure (Pierron et al 2007).…”

Section: Introductionmentioning

confidence: 96%

“…Moreover, Cd impairment on lipid metabolism has also been demonstrated on fish and mammalian species (Pierron et al 2007;Larregle et al 2008). This effect observed in European eels was mainly explained by an increased utilisation of triglycerides for the renewal of damaged lipid or to provide energy under Cd exposure (Pierron et al 2007). On the other hand, in rat exposed to Cd, the fatty acids content increased in cytosol and a hypertriglyceridemia appeared in relation to the decreased activity of lipoprotein lipase (LPL) (Larregle et al 2008).…”

Section: Introductionmentioning

confidence: 97%

Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata

et al. 2009

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In environment, birds often fast in connection with breeding, migration or drastic climatic conditions and need to mobilize lipid reserves during these periods. The impairment of lipid metabolism by cadmium (Cd; 1 mg kg(-1) added in diet) was investigated on palmiped Cairina moschata. Expression levels of genes involved in lipid metabolism, mitochondrial metabolism and detoxification were investigated in liver and muscle of ducks. Lipid content in muscle and liver were analysed and plasma triglycerides were quantified. After 20 days, ducks exposed to Cd displayed a lower body weight and lower lipid content in liver than controls. In muscle, the increase of lipid content was only significant for control ducks but not for exposed ducks. Exposed ducks appeared unable to sufficiently transport and store lipids into peripheral tissues. Cd impairs lipid metabolism by several ways. First, Cd triggered the down-regulation of fatty acids synthesis in liver even if the NADPH production and the mitochondrial metabolism are enhanced, suggesting a stronger energy needs. Secondly, the associated decrease of plasma triglycerides and lipoprotein lipase activity with Cd are consistent with impairment of lipids storage in peripheral tissues.

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“…Even if over fishing of glass eels at the mouth of many European rivers, habitat loss and physical obstacles to continental migration (e.g. hydropower turbines) are recognized to be the most important factors of this decline, recent reports tend to show that the notoriously complex life cycle of European eels puts them at special risk from pollution (Robinet and Feunteun 2002;Palstra et al 2006;Pierron et al 2007a;Pierron et al 2008). The biological cycle of the European eel (see Tesch 2003 or van Ginneken andMaes 2005) comprises four life stages, two metamorphoses and two trans-Atlantic migrations.…”

Section: Introductionmentioning

confidence: 98%

Ovarian gene transcription and effect of cadmium pre-exposure during artificial sexual maturation of the European eel (Anguilla anguilla)

Pierron

Baudrimont

Dufour³

et al. 2009

Biometals

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European eels are dangerously threatened with extinction. Recent advances tend to show that pollution could, in addition to other already identified factors, contribute to this drama. In a previous report, cadmium (Cd) pre-exposure was found to strongly stimulate the pituitary-liver-gonad axis of maturing female silver eels, leading, lastly, to oocytes atresia and eels mortality. The present work was performed to get more insights into the effects of Cd preexposure on eels' ovaries. The transcription levels of various genes involved in mitochondrial metabolism, in the cellular response to metal (metallothioneins, MTs) and oxidative stress (catalase, CAT) were investigated. Our results show that ovarian growth is associated with an up-regulation of mitochondrial genes. However, Cd pre-exposure was found to significantly impair this up-regulation. Such findings could explain, at least in part, why oocytes of Cd pre-contaminated eels could not reach final maturation. Concerning MTs, despite the end of the experiment was marked by a strong increase in their gene transcription levels in both eel groups, MTs protein content was found to increase only in the case of Cd pre-contaminated eels. Since this increase in MTs protein content was associated with a massive entry of Cd in gonads, our findings suggest that MTs mRNA, that are normally accumulated in oocytes to cope with the future needs, can be activated and translated in response to Cd exposure.

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Impairment of lipid storage by cadmium in the European eel (Anguilla anguilla)

Cited by 115 publications

References 37 publications

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata

Ovarian gene transcription and effect of cadmium pre-exposure during artificial sexual maturation of the European eel (Anguilla anguilla)

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