Impairment of host-versus-graft reaction in pregnant mice

Clark, David A.; McDermott, Mark R.; Szewczuk, Myron R.

doi:10.1016/0008-8749(80)90404-9

Cited by 132 publications

(20 citation statements)

References 31 publications

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“…This murine model provides an established experimental approach particularly in pregnancies challenged by stress [37][38][39][40][41][42]. It has been demonstrated that allogenically pregnant mice subjected to restraint or ultrasonic sound stress early in gestation showed a significant increase in the abortion rate [37][38][39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Progesterone induces a switch in oligosaccharyltransferase isoform expression: Consequences on IgG N-glycosylation

Prados¹,

Blunda²,

Szekeres-Barthó³

et al. 2011

Immunology Letters

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Section: Discussionmentioning

confidence: 99%

Progesterone induces a switch in oligosaccharyltransferase isoform expression: Consequences on IgG N-glycosylation

Prados¹,

Blunda²,

Szekeres-Barthó³

et al. 2011

Immunology Letters

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“…The well-established abortion-prone (AP) combination consisting of CBA/J females mated with DBA/2J males as well as controls having normal pregnancies (NP), CBA/J females mated with BALB/c males, were employed in this study [29]. Foxp3 gfp transgenic mice in a C57/BL6 background [30], kindly provided by Prof. Rudensky, were also included in the study.…”

Section: Methodsmentioning

confidence: 99%

Blockage of Heme Oxygenase-1 Abrogates the Protective Effect of Regulatory T Cells on Murine Pregnancy and Promotes the Maturation of Dendritic Cells

et al. 2012

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Regulatory T cells (Treg) play an important role in fetal protection. They expand during normal pregnancy and protect fetal antigens from maternal effector cells. Their effect is associated with the up-regulation of tolerance-associated molecules at the fetal-maternal interface. Among these, Heme Oxygenase-1 (HO-1, coded by Hmox1) is of special importance as its blockage correlates with increased abortion rates and its up-regulation positively affects pregnancy outcome. Here, we aimed to investigate whether the protective effect of Treg is mediated by HO-1 in a mouse model. HO-1 blockage by Zinc Protoporhyrin (ZnPPIX) abrogated the protective effect of Treg transfer. We found that HO-1 is important in maintaining maternal dendritic cells (DCs) in an immature state, which contributes to the expansion of the peripheral Treg population. This brings to light one essential pathway through which Treg mediates the semi-allogeneic fetus tolerance.

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“…The primary model comprises a comparison between CBA/J females mated to DBA/2 males and CBA/J females mated to males of other strains, including C3H, C57BL/6 and the most common, Balb/c. Early studies suggested a high rate of non-pregnancy in DBA/2-mated CBA/J females (Clark, et al 1980). However, mothers of related CBA/J strains, CBA/Ca and CBA/N do not exhibit this phenomenon (Bobe and Kiger 1989).…”

Section: Introductionmentioning

confidence: 99%

“…placenta) would affect both systemic and local immunity of pregnant mice and support fetal tolerance. The CBA/J x DBA/2 model first arose in the context of delineating these putative suppressive factors (Clark, et al 1980) as the model was held up as an example of adverse pregnancy outcome (resorption) in the face of deficiency of such suppression (Clark, et al 1980). Continued study of the model was also a venue for examining the production of soluble suppressive factors produced in the placenta or decidua.…”

Section: Introductionmentioning

confidence: 99%