Impairment of Health-Related Quality of Life in Patients With Inflammatory Bowel Disease: a Spanish Multicenter Study

Casellas, Francesc; Arenas, Juan; Baudet, J; Fábregas, S; García, Natalia Cornejo; Gelabert, J.; Medina, Carlos; Ochotorena, Itziar; Papo, Matthias; Rodrigo, Luı́s; Malagelada, J.-R.

doi:10.1097/01.mib.0000159661.55028.56

Cited by 244 publications

(181 citation statements)

References 43 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…However, studies that were more adequately powered to detect differences have found that distress levels change in parallel with disease activity 11,16,60 , and those in relapse have poorer quality of life than those in remission 61,62 . The findings from this study, showing clear differences in distress between a matched community non-IBD sample and those with active IBD, add further support to the understanding that it is not having the disease per se that relates to psychological difficulties, but rather that disease activity is pivotal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Graff

Walker

Clara

et al. 2009

American Journal of Gastroenterology

107

View full text Add to dashboard Cite

Psychological health and IBD 2Background: This study compares a community IBD sample with a matched non-IBD community sample on psychological functioning and health perceptions. Methods:Participants in the population-based Manitoba IBD Cohort Study (n=388) were directly compared with sex, age, and region-matched controls from a national random-sample health survey on aspects of psychological health, coping, and perceived general health. Results:The IBD sample overall had lower psychological wellbeing and mastery, and higher distress than the non-IBD controls (p < 0.02). Those with IBD used avoidant coping significantly more often, and active coping modestly more often than the non-IBD sample; both had similar levels of 'self-soothing' behaviors. Crohn's disease and ulcerative colitis participants had similarly poor levels of functioning along these dimensions compared to the non-IBD sample, as did those with active disease (p < 0.01). However, those with inactive disease were similar to the non-IBD sample, and had modestly higher mastery levels. While nearly half of the non-IBD group reported chronic health conditions, those with IBD were threefold more likely to report poorer health (OR 3.07, 95% CI 2.10-4.47). Psychological factors explained a greater amount of variance in perceived health for the IBD than the non-IBD sample. Conclusions:Those with IBD have significantly poorer psychological health than those without IBD and view their general health status more negatively, although adaptive stress coping strategies were similar. However, when disease is quiescent there is little detriment to functioning. Active disease should be a flag to consider psychological needs in the care of the IBD patient.Psychological health and IBD 3

show abstract

Section: Discussionmentioning

confidence: 99%

“…Quality of life has been found to decline in parallel with increased disease severity 16 . Some studies have reported poorer functioning of IBD patients and disruption in quality of life even when the disease was in remission 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Graff

Walker

Clara

et al. 2009

American Journal of Gastroenterology

107

View full text Add to dashboard Cite

show abstract

“…Casellas et al 126 administered the Inflammatory Bowel Disease Questionnaire (IBDQ) and the EQ-5D among 1156 Spanish IBD patients, 628 with CD and 528 with UC. These were composed of both inpatients and outpatients: 141 and 487 respectively for CD, and 108 and 420 for UC.…”

Section: Doi: 103310/hta17550mentioning

confidence: 99%

“…It appears that the valuation of the EQ-5D used the Spanish valuation set as reported in Badia et al. 127 Within a multivariate regression analysis of the IBDQ, Cassellas et al 126 found that the underlying condition was not statistically significant, with a t-statistic of only -0.067. The 25th percentile, median and 75th percentile EQ-5D preference values were estimated.…”

Section: Doi: 103310/hta17550mentioning

confidence: 99%

“…Health-related quality of life Although Konig et al 122 provide QoL estimates for both CD and UC using the EQ-5D, their relevance is limited by the German mapping function being used. Similarly, although Casellas et al 126 also provide QoL estimates for both CD and UC using the EQ-5D, their relevance is limited by the Spanish mapping function 124 provide QoL estimates for both CD and UC using the EQ-5D and the UK social tariff. Their sample sizes are also reasonably large: 270 with CD and 253 with UC, although there may be some concerns around sample selection given that only a little over one-third of the 1447 originally contacted agreed to participate.…”

Section: Baseline Patient Characteristics: Secondary Carementioning

confidence: 99%

See 1 more Smart Citation

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Waugh

Cummins²,

Royle³

et al. 2013

Health Technology Assessment

227

201

View full text Add to dashboard Cite

Should Cost‐Effectiveness Analysis Include the Cost of Consumption Activities? AN Empirical Investigation

2015

View full text Add to dashboard Cite

There has been a debate on whether cost-effectiveness analysis should consider the cost of consumption and leisure time activities when using the quality-adjusted life year as a measure of health outcome under a societal perspective. The purpose of this study was to investigate whether the effects of ill health on consumptive activities are spontaneously considered in a health state valuation exercise and how much this matters. The survey enrolled patients with inflammatory bowel disease in Germany (n = 104). Patients were randomized to explicit and no explicit instruction for the consideration of consumption and leisure effects in a time trade-off (TTO) exercise. Explicit instruction to consider non-health-related utility in TTO exercises did not influence TTO scores. However, spontaneous consideration of non-health-related utility in patients without explicit instruction (60% of respondents) led to significantly lower TTO scores. Results suggest an inclusion of consumption costs in the numerator of the cost-effectiveness ratio, at least for those respondents who spontaneously consider non-health-related utility from treatment. Results also suggest that exercises eliciting health valuations from the general public may include a description of the impact of disease on consumptive activities.

show abstract

Impairment of Health-Related Quality of Life in Patients With Inflammatory Bowel Disease: a Spanish Multicenter Study

Abstract: UC and CD impair patients' HRQOL, and the degree of impairment depends on disease activity but is independent of the type of disease and place of residence.

Cited by 244 publications

References 43 publications

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Stress Coping, Distress, and Health Perceptions in Inflammatory Bowel Disease and Community Controls

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Should Cost‐Effectiveness Analysis Include the Cost of Consumption Activities? AN Empirical Investigation

Contact Info

Product

Resources

About