Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation

Takeda, Atsüshi; Itoh, Hiromasa; Imano, Sachie; Oku, Naoto

doi:10.1016/j.neuint.2006.06.005

Cited by 28 publications

(16 citation statements)

References 35 publications

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“…Post‐weaned Zn deficiency (CD) induced a down‐regulation of PPII activity only in AH, whereas the whole‐life deficient group (DD) presented low enzyme activity in both MBH and AH. The down‐regulation of MBH PPII of DD group could be accounted for by its low Zn brain content, which is in agreement with the described decreased Zn content in hippocampus and amygdala of young rats when subjected to 4 weeks of Zn deficiency (Takeda et al, 2003a,b; Takeda et al, 2006).…”

Section: Discussionsupporting

confidence: 87%

“…regulation of MBH PPII of DD group could be accounted for by its low Zn brain content, which is in agreement with the described decreased Zn content in hippocampus and amygdala of young rats when subjected to 4 weeks of Zn deficiency (Takeda et al, 2003a,b;Takeda et al, 2006). This decrease of Zn brain levels in DD might be reflecting their lower Zn serum content, which could reduce mineral's availability Fig.…”

Section: Male Adult Ratssupporting

confidence: 86%

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Mediobasal hypothalamic and adenohypophyseal TRH‐degrading enzyme (PPII) is down‐regulated by zinc deficiency

Alvarez-Salas

Alcántara-Alonso

Matamoros-Trejo

et al. 2015

Intl J of Devlp Neuroscience

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Thyrotropin-releasing hormone (TRH) synthesized in hypothalamic paraventricular nucleus directs hypothalamus-pituitary-thyroid (HPT) axis function, regulating thyrotropin release from adenohypophysis and thyroid hormones serum concentration. Pyroglutamyl aminopeptidase II (PPII), a Zn-dependent metallopeptidase located in adenohypophysis and medial-basal-hypothalamus degrades TRH released from the median eminence and participates in HPT axis function by regulating TRH-induced thyrotropin release from adenohypophysis. It is unknown whether dietary Zn deficiency down-regulates PPII. Our aim was to compare adenohypohyseal and medial-basal-hypothalamic PPII activity and expression of adult rats fed a Zn-deficient diet (2ppm) throughout their lifespan (DD), prenatally (DC) or after weaning (CD) vs. that of animals fed a control diet (20ppm:CC). Female rats consumed a Zn-deficient or control diet from two weeks before gestation and up to the end of lactation. We analyzed adenohypophyseal and medial-basal-hypothalamic PPII activity of dams and male offspring when adults; its relation to median eminence TRH, serum thyrotropin, leptin and thyroid hormones concentration. Offspring ate the same diet as their dams (CC, DD) or were switched from dietary regime after weaning (CD, DC) and until 2.5 months of age. DD males showed decreased adenohypophyseal and medial-basal-hypothalamic PPII activity, along with high thyrotropin serum concentration. Post-weaning Zn-deficiency (CD) decreased PPII activity only in adenohypophysis and increased thyrotropin circulating levels. Zn-replenishment (DC) normalized PPII activity in both regions and serum thyrotropin concentration. Adenohypophyseal PPII activity decreased and prolactin levels increased in Zn-deficient dams. We concluded that long-term changes in dietary Zn down-regulate PPII activity independently of T3, increasing thyrotropin serum concentration, overall resembling sub-clinical hypothyroidism.

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Section: Discussionsupporting

confidence: 87%

Section: Male Adult Ratssupporting

confidence: 86%

Mediobasal hypothalamic and adenohypophyseal TRH‐degrading enzyme (PPII) is down‐regulated by zinc deficiency

Alvarez-Salas

Alcántara-Alonso

Matamoros-Trejo

et al. 2015

Intl J of Devlp Neuroscience

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“…The results were similar to the previous findings where Zn deficiency was one of the causes of anxiety-like behaviour. 13,30 It was also seen that there was a slight potentiating effect when a lower dose of Zn (10 mg/kg) with diazepam (1 mg/kg) was given. .…”

Section: Discussionmentioning

confidence: 98%

Effect of zinc in animal models of anxiety, depression and psychosis

et al. 2012

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The role of zinc (Zn) in anxiety, depression and psychosis was studied in rodents. Zn was administered at doses of 15 and 20 mg/kg intraperitoneally for 7 days. Both doses of Zn reduced the immobility time and increased the swimming time in the modified forced swim test. In the elevated plus maze test, increases in the number of open arm entries and time spent in the open arms were observed with both doses of Zn. In the amphetamine (1 and 2 mg/kg subcutaneously) induced locomotor activity test both doses of Zn produced reduction in the total movement time, mean velocity and stereotypic movements. Extrapyramidal symptoms such as catalepsy in animals are usually observed with conventional antipsychotic agents; but in the present study, Zn at doses of 15 and 20 mg/kg did not produce any cataleptic state in mice. The results of the present study demonstrated the anxiolytic, antidepressant and antipsychotic-like effects of Zn metal ion, which may be due to its N-methyl d-aspartate receptor antagonistic activity. Concurrent administration of a lower dose of Zn with standard existing anxiolytic and antidepressant drugs in this study showed potentiating effect, suggesting that Zn could exert beneficial role when prescribed as add-on medicine in the psychiatric illnesses. The results obtained in this study are preliminary, as further research is required to confirm the exact role of Zn metal in the investigated central nervous system disorders.

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“…Zn has been found to be associated with GABA and glutamate regulation, particularly through anxiolytic activity, modulating GABAergic inhibition and seizure susceptibility, 40–42 and deficiency of Zn has been found to be associated with GABAergic impairment. 43…”

Section: Discussionmentioning

confidence: 99%

Analysis of Plasma Zinc and Copper Concentration, and Perceived Symptoms, in Individuals with Depression, Post Zinc and Anti-Oxidant Therapy

Russo

2011

Nutr Metab Insights

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Aim:To assess plasma Zn and Cu levels in individuals with depression.Subjects and methods:Plasma from 73 clinically depressed individuals, 38 individuals with anxiety and 16 controls were tested for plasma Zn and Cu concentration using inductively-coupled plasma-mass spectrometry.Results:Depressed individuals, with and without secondary anxiety, had decreased plasma Zn and elevated plasma Cu compared to controls. Zn normalized (increased to the level of normal controls) but Cu increased in individuals with depression (with and without secondary anxiety), after Zn therapy, whereas both plasma Zn increased and Cu levels decreased in anxiety, with and without secondary depression, after Zn therapy. Individuals with depression,with and without secondary anxiety, had significantly higher symptom severity when compared to neurotypical controls. Symptom severity in individuals with anxiety (both with and without secondary depression) significantly decreased after Zn therapy, whereas symptoms remained the same in individuals with primary depression.Discussion:These data show an association between Zn and Cu plasma levels and clinically depressed individuals, and suggest that high Cu levels are associated with high symptom severity.

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Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation

Cited by 28 publications

References 35 publications

Mediobasal hypothalamic and adenohypophyseal TRH‐degrading enzyme (PPII) is down‐regulated by zinc deficiency

Mediobasal hypothalamic and adenohypophyseal TRH‐degrading enzyme (PPII) is down‐regulated by zinc deficiency

Effect of zinc in animal models of anxiety, depression and psychosis

Analysis of Plasma Zinc and Copper Concentration, and Perceived Symptoms, in Individuals with Depression, Post Zinc and Anti-Oxidant Therapy

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