Impairment of decision making associated with disruption of phase-locking in the anterior cingulate cortex in viscerally hypersensitive rats

Cao, Bing; Wang, Jun; Mu, Li; Poon, David Chun-Hei; Liu, Ying

doi:10.1016/j.expneurol.2016.09.010

Cited by 28 publications

(50 citation statements)

References 43 publications

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“…Thus, brain network synchronization requires active central myelination. These findings are consistent with our other recent findings in the rat with chronic visceral pain (31, 33) and the maternally separated rat (34), which show that a decision-making deficit is associated with disruption of SFC and desynchronized θ waves between the basolateral amygdala and ACC (33, 34). However, we realized that further studies are wanted to demonstrate the direct effects of behaviorally relevant brain neuronal activity on myelin plasticity in vivo .…”

Section: Discussionsupporting

confidence: 93%

“…Measurement of visceral sensitivity in animals is mainly based on brain stem reflexes (29, 32, 33). Two-way ANOVA revealed that there was no difference in the factor of demyelination, indicating that demyelination into the ACC does not affect visceral pain sensation.…”

Section: Resultsmentioning

confidence: 99%

“…Detailed procedures of multiple-channel data analyses have been described in our recent publications (28, 31–36). …”

Section: Methodsmentioning

confidence: 99%

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Schema‐like learning and memory consolidation acting through myelination

et al. 2019

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Memory is a dynamic brain function that is continually processed after encoding. Although psychologic concepts of mental schema are now well established, they have rarely been considered in animal studies. We used a behavior paradigm of multiple flavor-place paired associates (PAs) and showed that memory schema facilitates fast acquisition of new PAs in a single trial. The hippocampus is necessary for the encoding of new PAs and for memory retrieval within a certain time window—24 h following new PA consolidation. Whereas the anterior cingulate cortex (ACC) plays a critical role for dynamic PA learning and consolidation during training sessions, ACC is essential in schema representation and activation. New myelin generation is essential for learning. Neural activity in the cortical regions impacts myelination by regulating oligodendrocyte (OL) proliferation, differentiation, and myelin formation. Here, we show that newly formed OL progenitor cells and mature OLs are increased following repeated PA learning and that establishment of the memory schema is associated with enhanced myelin strength in the ACC region. Furthermore, to ensure that myelination is necessary for the acquisition of paired-associate learning, ACC lysolecithin-induced demyelination revealed impaired PA learning associated with decrease in ACC θ band power and reduced spike-field coherence and phase-locking in ACC.—Hasan, M., Kanna, M. S., Jun, W., Ramkrishnan, A. S., Iqbal, Z., Lee, Y., Li, Y. Schema-like learning and memory consolidation acting through myelination.

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Schema‐like learning and memory consolidation acting through myelination

et al. 2019

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“…Additionally, bidirectional association fibers between the ACC-IC and ACC-hippocampus have been verified in many previous anatomical studies through the use of anterograde or retrograde tracers [10][11][12]. On the other hand, more and more research suggests that one factor participating in the development of IBS is the disruption of associations between different nuclei through association fibers or projection fibers, which facilitate information flow between brain regions [13,14]. However, there has been a lack of study focusing on the the role of associations between different nuclei in the limbic system, especially pain-related brain regions like the ACC, IC and hippocampus, in the development of IBS.…”

Section: Introductionmentioning

confidence: 73%

Up-regulation of HTR1A reverses stress-induced visceral hypersensitivity through modulating interactions among the anterior cingulate cortex, insular cortex and hippocampus

Xuan

Zhou

et al. 2020

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Background: This study aimed to explore the effect of 5-HT1A receptors (HTR1A) on activation of the anterior cingulate cortex and simultaneous regulation of neural activity in the insular cortex and hippocampus.Methods: The IBS rat model was established via chronic water avoidance stress (WAS). Visceral sensitivity was measured by electromyogram, and anxiety-like behaviours were evaluated by the open field test. HTR1A-specific lentivirus expressing green fluorescent protein was used to overexpress or down-regulate HTR1A expression. Protein expression levels were detected by western blot.Results: Up-regulation of HTR1A in ACC could inhibit ACC sensitization and reverse the visceral hypersensitivity and anxiety-like behaviours induced by chronic psychological stress. In contrast, down-regulation of HTR1A in ACC might promote these behaviors in IBS rats. Additionally, up-regulation of HTR1A in ACC could inhibit IC and hippocampus sensitization, while down-regulation might have the opposite effect.Conclusions: In IBS rats, HTR1A could modulate ACC activation and interactions among the ACC, IC and hippocampus. These effects might in turn contribute to the development of visceral hypersensitivity and anxiety-like behaviours induced by chronic psychological stress.

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“…Numerous studies, both in vitro and in vivo , have focused on the mechanisms that sustain oscillations and their synchronization as well as on the relationship between neural oscillations and network dynamics, e.g., for a review, see ( Buzsaki and Draguhn, 2004 ). Abnormal increments in synchronization are reported as a key component in chronic neurological disorders, e.g., Parkinson’s disease and epilepsy, and in the impairment of decision-making capabilities ( Ross et al, 2013 ; Tan et al, 2013 ; Broggini et al, 2016 ; Cao et al, 2016 ). Our study demonstrates that widespread oscillations can be induced in a neural population in vitro by using a coordinated electrical stimulation paradigm with biphasic rectangular waves.…”

Section: Discussionmentioning

confidence: 99%

Cortical Network Synchrony Under Applied Electrical Field in vitro

2018

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Synchronous network activity plays a crucial role in complex brain functions. Stimulating the nervous system with applied electric field (EF) is a common tool for probing network responses. We used a gold wire-embedded silk protein film-based interface culture to investigate the effects of applied EFs on random cortical networks of in vitro cultures. Two-week-old cultures were exposed to EF of 27 mV/mm for <1 h and monitored by time-lapse calcium imaging. Network activity was represented by calcium signal time series mapped to source neurons and analyzed by using a community detection algorithm. Cortical cultures exhibited large scale, synchronized oscillations under alternating EF of changing frequencies. Field polarity and frequency change were both found to be necessary for network synchrony, as monophasic pulses of similar frequency changes or EF of a constant frequency failed to induce correlated activities of neurons. Group-specific oscillatory patterns were entrained by network-level synchronous oscillations when the alternating EF frequency was increased from 0.2 Hz to 200 kHz. Binary responses of either activity increase or decrease contributed to the opposite phase patterns of different sub-populations. Conversely, when the EF frequency decreased over the same range span, more complex behavior emerged showing group-specific amplitude and phase patterns. These findings formed the basis of a hypothesized network control mechanism for temporal coordination of distributed neuronal activity, involving coordinated stimulation by alternating polarity, and time delay by change of frequency. These novel EF effects on random neural networks have important implications for brain functional studies and neuromodulation applications.

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Impairment of decision making associated with disruption of phase-locking in the anterior cingulate cortex in viscerally hypersensitive rats

Cited by 28 publications

References 43 publications

Schema‐like learning and memory consolidation acting through myelination

Schema‐like learning and memory consolidation acting through myelination

Up-regulation of HTR1A reverses stress-induced visceral hypersensitivity through modulating interactions among the anterior cingulate cortex, insular cortex and hippocampus

Cortical Network Synchrony Under Applied Electrical Field in vitro

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