Impairment in the aversive memory of mice in the inhibitory avoidance task but not in the elevated plus maze through intra-amygdala injections of histamine

Daher, Fernanda; Mattioli, Rosana

doi:10.1016/j.pbb.2015.05.023

Cited by 8 publications

(8 citation statements)

References 61 publications

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“…The EPM test, which was originally developed to estimate anxiety in rodents [28], was modified to evaluate spatial learning and memory in mice. The parameters measured are not the same: the number of entries into the open and closed arms, the time spent in the open arms for anxiety but for memory processes, the transfer latency, which reflects the time the mice took to move from the open arm to either of the enclosed arms [29,30]. In agreement with previous studies, scopolamine injection caused prolongation of transfer latency into enclosed arms suggesting impairment of learning and memory [31,32].…”

supporting

confidence: 74%

Involvement of Antioxidant System in the Amelioration of Scopolamine-Induced Memory Impairment by Grains of Paradise (Aframomum melegueta K. Schum.) Extract

2016

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Grains of paradise () K. Schum is used to flavour foods and used as memory enhancer and anti-aging in traditional African medicine. This study examine the influence of ethanolic seed extract of (AFM) on cognitive impairment induced by scopolamine in rodents. AFM (6.25, 12.5 or 25 mg/kg, .) or tacrine (5 mg/kg,.) was administered for 3 consecutive days, 1 h post-treatment on day 3, scopolamine (3 mg/kg, .) was given, 5 min later, cognition was evaluated in the Y-maze and elevated plus maze (EPM) tests in mice as well as the Morris water maze (MWM) paradigm in rats. Biomarkers of oxidative stress in the prefrontal cortex, striatum and hippocampus of rats were evaluated after the MWM task. The antioxidant capacity of AFM was evaluated in vitro using the 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) and ferric ion reducing power (FRAP) assays. Scopolamine significantly reduced (38.72%) spontaneous alternation behavior in the Y-maze and increase in transfer latency in the EPM test on day 2, which was ameliorated by AFM (25 mg/kg; 49.86%, 71.55%, respectively) in mice. In addition, AFM prevented the spatial learning deficit induced by scopolamine in the MWM task. Similarly, scopolamine-induced oxidative-nitrosative stress was attenuated by AFM treatment, evidenced in decreased malondialdehyde and nitrite levels, restoration of glutathione and superoxide dismutase levels. Interestingly, AFM exhibited notable scavenging activities against DPPH, NO and FRAP radicals. These results showed that seed extract prevented scopolamine-induced memory impairments through enhancement of antioxidant defense systems.

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supporting

confidence: 74%

Involvement of Antioxidant System in the Amelioration of Scopolamine-Induced Memory Impairment by Grains of Paradise (Aframomum melegueta K. Schum.) Extract

2016

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“…Previous studies conducted in our group research showed that cerebellar histaminergic system participation in the consolidation of emotional memory is dependent on an anxiety or fear component (GIANLORENÇO et al, 2013); furthermore, the amygdalar histaminergic system induces impairment in the aversive memory in IAT but not in the EPM, suggesting that HA modulates the systems involved in anxiety and fear learning differently (DAHER et al, 2015). Furthermore, the operational need to define anxiety versus fear arises from the conceptions that these two categories of emotion are mediated by shared as well as independent subsystems in the brain (DAVIS et al, 2010).…”

Section: Discussionmentioning

confidence: 77%

“…On the other hand, microinjections of HA in the same dose enhances memory consolidation of inhibitory avoidance learning in mice (GIANLORENÇO et al, 2013), which suggests a different role for the same dose of histamine in a memory model that uses punishment. A study conducted by Daher et al (2015) showed that the amygdaloid histaminergic system could modulate anxiety-related behaviors in the EPM and impair the retrieval process in fear conditioning with a strong aversive stimulus.…”

Section: Introductionmentioning

confidence: 99%

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Intra-amygdala microinjections of chlorpheniramine impair memory formation or memory retrieval in anxiety- and fear-mediated models

Serafim

Russo

Fernandes

et al. 2016

Brain Research Bulletin

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H1 receptor histaminergic antagonist, chlorpheniramine (CPA) participates in cognitive performance in various animal models. However, little is known regarding the effects of CPA microinjection into the amygdala on emotional behavior. The purpose of this study was to investigate whether CPA microinjection into the amygdala has the same effect on two models, one anxiety- and the other fear-mediated, in various memory stages using the elevated plus maze (EPM) and the inhibitory avoidance task (IAT) tests. Two experiments were performed with seventy-two adult male Swiss mice. Behavioral testing was performed on two consecutive days, and in both experiments, before each trial, the animals received bilateral microinjections of saline (SAL) or CPA (0.16 nmol). The animals were re-exposed to the EPM or IAT 24h after the first trial. Four experimental groups were tested: SAL-SAL, SAL-CPA, CPA-SAL and CPA-CPA. In experiment 1, a decreased open arm exploration (% open arm entries, %OAE and% open arms time, %OAT) for SAL-SAL and SAL-CPA was showed, while these measures did not decrease for the CPA-SAL and CPA-CPA groups in Trial 2. In experiment 2, an increase of retention latency in relation to training 2 for the groups SAL-SAL and CPA-SAL and a significant decrease in latency for the group SAL-CPA was revealed. These results indicate that chlorpheniramine microinjection into the amygdala impairs emotional memory acquisition and/or consolidation in the EPM and retrieval of IAT.

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“…Panksepp (1998a) localized both the fear and rage systems to the neural pathway running from the amygdala, via the medial hypothalamus, down to the mesencephalic periaqueductal gray, although within the amygdala, the two systems can be clearly differentiated, with the fear system being more lateral and the rage system being more medial. Evidence repeatedly shows that the amygdala contributes to the acquisition of Pavlovian fear conditioning and the modulation of memory consolidation of inhibitory avoidance (Daher & Mattioli, 2015;Moscarello & LeDoux, 2013;Wilensky, Schafe, & LeDoux, 2000;Zinn et al, 2009). At the moment of retrieving learned inhibitory avoidance, the entorhinal cortex seems to act as an efferent output of the amygdala and hippocampus (Izquierdo & Medina, 1993).…”

Section: The Constancy Of Dream Contentmentioning

confidence: 99%

A Neuroanatomical Framework for Understanding Dream Content

Yu¹

2016

Sleep Hypn

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Sleep Hypn 2016;18(4):82-91 ABSTRACT The neurostructural model of dreaming avers that dreams are actively generated by the neural network formed by the mesolimbic-dopaminergic pathway, the ventromesial-orbitofrontal cortex, and the inferomesial temporal-limbicoccipital pathway as a result of the disengagement of the frontal convexity. Although the narrative content of dreams usually appears to be uncanny and unintelligible, there are typical dream themes that are similarly experienced by most people. On the other hand, some common waking-life activities that entail prefrontal executive functions rarely emerge in dreams. The cross-cultural resemblance of prevalence profiles for typical dream themes suggests that the formation of dream images is regularly biased toward a specific group of themes and is operated on by highly stable mechanisms and predispositions. In this article, I propose that the functional architecture of dreaming as depicted by the neurostructural model can provide a framework for understanding these predispositions.

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Impairment in the aversive memory of mice in the inhibitory avoidance task but not in the elevated plus maze through intra-amygdala injections of histamine

Cited by 8 publications

References 61 publications

Involvement of Antioxidant System in the Amelioration of Scopolamine-Induced Memory Impairment by Grains of Paradise (Aframomum melegueta K. Schum.) Extract

Involvement of Antioxidant System in the Amelioration of Scopolamine-Induced Memory Impairment by Grains of Paradise (Aframomum melegueta K. Schum.) Extract

Intra-amygdala microinjections of chlorpheniramine impair memory formation or memory retrieval in anxiety- and fear-mediated models

A Neuroanatomical Framework for Understanding Dream Content

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